Polavarapu, Rohini Gongora, Maria Carolina Winkles, Jeffrey A Yepes, Manuel
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily. TWEAK acts on responsive cells via binding to a small cell-surface receptor named fibroblast growth factor-inducible-14 (Fn14). TWEAK can stimulate numerous cellular responses including cell proliferation, migration, and proinflammator...
Persidsky, Yuri Ramirez, Servio H. Haorah, James Kanmogne, Georgette D.
Published in
Journal of Neuroimmune Pharmacology
The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain tissues with nutrients, and filters harmful compounds from the brain back to the bloodstream. The close interaction between BMVEC and other components of the neurovascular...
Zhao, Yuhai Cui, Jian-Guo Lukiw, Walter J.
Published in
Molecular Neurobiology
Neurons, glia, and endothelial cells of the cerebral microvasculature co-exist in intimate proximity in nervous tissues, and their homeostatic interactions in health, as well as coordinated response to injury, have led to the concept that they form the basic elements of a functional neurovascular unit. During the course of normal cellular metabolis...
Vexler, Zinaida S. Tang, Xian Nan Yenari, Midori A.
Published in
Clinical neuroscience research
This chapter will discuss the current knowledge of the contribution of systemic and local inflammation in acute and sub-chronic stages of experimental stroke in both the adult and neonate. It will review the role of specific cell types and interactions among blood cells, endothelium, glia, microglia, the extracellular matrix and neurons – cumulativ...
Banerjee, Swati Bhat, Manzoor A
Published in
Annual review of neuroscience
The blood brain barrier (BBB) evolved to preserve the microenvironment of the highly excitable neuronal cells to allow for action potential generation and propagation. Intricate molecular interactions between two main cell types, the neurons and the glial cells, form the underlying basis of the critical functioning of the nervous system across spec...
Zhao, Jing Moore, Anthony N Redell, John B Dash, Pramod K
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The integrity of the blood-brain barrier (BBB) is critical for normal brain function, and its compromise contributes to the pathophysiology of a number of CNS diseases and injuries. Using a rodent model of brain injury, the present study examines the pathophysiology of BBB disruption. Western blot and immunohistochemical analyses indicate that brai...
Milner, Richard Hung, Stephanie Wang, Xiaoyun Spatz, Maria del Zoppo, Gregory J
Published in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
During focal cerebral ischemia, the detachment of astrocytes from the microvascular basal lamina is not completely explained by known integrin receptor expression changes. Here, the impact of experimental ischemia (oxygen-glucose deprivation (OGD)) on dystroglycan expression by murine endothelial cells and astrocytes grown on vascular matrix lamini...
Ramos, Raddy L Smith, Phoebe T Croll, Susan D Brumberg, Joshua C
Published in
Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience
One challenge of neuroscience educators is to make accessible to students as many aspects of brain structure and function as possible. The anatomy and function of the cerebrovasculature is among many topics of neuroscience that are underrepresented in undergraduate neuroscience education. Recognizing this deficit, we evaluated methods to produce ar...
Liu, R Gao, M Qiang, G-F Zhang, T-T Lan, X Ying, J Du, G-H
Published in
Neuroscience
Luteolin (3',4',5,7-tetrahydroxyflavone) is an important member of the flavonoid family. It exhibits strongly anti-inflammatory, antioxidant and phytoestrogen-like activities. In the present study, we examined the anti-amnesic and protective effects of luteolin against Abeta(25-35)-induced toxicity in mice. Mice were given an i.c.v. injection of ag...
McCarty, Joseph H
Published in
Cell adhesion & migration
The mammalian central nervous system (CNS) is comprised of billions of neurons and glia that are intertwined with an elaborate network of blood vessels. These various neural and vascular cell types actively converse with one another to form integrated, multifunctional complexes, termed neurovascular units. Cell-cell communication within neurovascul...
