Ore, Ayokanmi Akinloye, Oluseyi Adeboye Adeogun, Abideen Idowu Ugbaja, Regina Ngozi Morifi, Eric Makatini, Maya Moepya, Refilwe Mbhele, Thapelo
Published in
Journal of food biochemistry
Non-alcoholic fatty liver disease (NAFLD) is a hepatic condition with multiple pathological features and it currently has no specific treatment or approved drug. Wonderful kolanut widely consumed fresh or cooked has been applied in the treatment of numerous diseases in folk medicine. In this study, we evaluate the therapeutic potentials of hydroeth...
Reho, John J. Nakagawa, Pablo Mouradian, Gary C. Jr Grobe, Connie C. Saravia, Fatima L. Burnett, Colin M. L. Kwitek, Anne E. Kirby, John R. Segar, Jeffrey L. Hodges, Matthew R.
...
Published in
Frontiers in Physiology
Cardiovascular disease represents the leading cause of death in the United States, and metabolic diseases such as obesity represent the primary impediment to improving cardiovascular health. Rodent (mouse and rat) models are widely used to model cardiometabolic disease, and as a result, there is increasing interest in the development of accurate an...
Argunhan, Fulye Brain, Susan D.
Published in
Frontiers in Physiology
The treatment of hypertension and heart failure remains a major challenge to healthcare providers. Despite therapeutic advances, heart failure affects more than 26 million people worldwide and is increasing in prevalence due to an ageing population. Similarly, despite an improvement in blood pressure management, largely due to pharmacological inter...
Ajouaou, Yousra; Azouz, Abdulkader; Taquin, Anaelle; Denanglaire, Sebastien; Hussein, Hind; 142483; Krayem, Mohammad; Andris, Fabienne; Moser, Muriel; Goriely, Stanislas; Leo, Oberdan;
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The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) in numerous cell types, including T lymphocytes. The role of oxygen sensor on immune cells, particularly on regulatory T cell (Treg) function, has not been fully elucidated. The purpos...
Tontanahal, Ashmita Sperandio, Vanessa Kovbasnjuk, Olga Loos, Sebastian Kristoffersson, Ann-Charlotte Karpman, Diana Arvidsson, Ida
Published in
Frontiers in Immunology
Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. col...
Ciencewicki, Jonathan M Herbert, Andrew S Storm, Nadia Josleyn, Nicole M Huie, Kathleen E McKay, Lindsay G A Griffiths, Anthony Dye, John M Willis, Todd Arora, Vikram
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Published in
The Journal of infectious diseases
Convalescent plasma has been used to treat many viral diseases including Ebola. The manufacture of a purified anti-Ebola virus (EBOV) intravenous immunoglobulin (IVIG) from pooled convalescent plasma is described in this paper. An enzyme-linked immunosorbent assay (ELISA) targeting an EBOV surface glycoprotein antigen was used to determine the immu...
Zheng, Xiaowei; Narayanan, Sampath; Xu, Cheng; Eliasson Angelstig, Sofie; Grunler, Jacob; Zhao, Allan; Di Toro, Alessandro; Bernardi, Luciano; Mazzone, Massimiliano; 53986; Carmeliet, Peter; 21003;
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Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development of diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this study, we hypothesized that ROS overproduction was secondary to the impaired responses to hypoxia due t...
Bakker, Gert-Jan Weischer, Sarah Ferrer Ortas, Júlia Heidelin, Judith Andresen, Volker Beutler, Marcus Beaurepaire, Emmanuel Friedl, Peter
Three-photon excitation has recently been demonstrated as an effective method to perform intravital microscopy in deep, previously inaccessible regions of the mouse brain. The applicability of 3-photon excitation for deep imaging of other, more heterogeneous tissue types has been much less explored. In this work, we analyze the benefit of high-puls...
Negi, Vidya Devi Khurana, Sandhya Bonney, Elizabeth A.
Published in
Frontiers in Virology
Pregnant mice infected with Lymphocytic Choriomeningitis Virus (Armstrong) (LCMV-Arm) experience high viral loads in the placenta and uterine tissue by 5–8 days post-infection, a time when the virus is nearly completely cleared from the spleen and blood. Interleukin 10 (IL-10) plays a crucial role in T cell responses associated with systemic viral ...
Ryu, Erica P. Davenport, Emily R.
Animals harbor diverse communities of microbes within their gastrointestinal tracts. Phylogenetic relationship, diet, gut morphology, host physiology, and ecology all influence microbiome composition within and between animal clades. Emerging evidence points to host genetics as also playing a role in determining gut microbial composition within spe...
