Zhang, Li Wang, Wenwen Kim, Sun Myoung Wang, Jianjun Zhou, Binfei Kong, Weijia Zheng, James Lin, Xi
Published in
Frontiers in Cell and Developmental Biology
Non-sensory cells in the sensory epithelium of the cochlea are connected extensively by gap junctions. Functionally null mutations in GJB6 (encoding Cx30) cause hearing loss in humans. In this study, we injected AAV1-CB7-Gjb2 into the scala media between P0-2 in the cochlea of Gjb6 −/− mice. The injection increased Cx26 expression and significantly...
Yang, Xiaofan Yin, Hongqiang Wang, Xiaojing Sun, Yueqing Bian, Xianli Zhang, Gaorui Li, Anning Cao, Aihua Li, Baomin Ebrahimi-Fakhari, Darius
...
Published in
Frontiers in Molecular Neuroscience
Mutations in the SCN8A gene encoding the voltage-gated sodium channel α-subunit Nav1. 6 have been reported in individuals with epilepsy, intellectual disability and features of autism spectrum disorder. SCN8A is widely expressed in the central nervous system, including the cerebellum. Cerebellar dysfunction has been implicated in autism spectrum di...
Gegner, Hagen M. Mechtel, Nils Heidenreich, Elena Wirth, Angela Cortizo, Fabiola Garcia Bennewitz, Katrin Fleming, Thomas Andresen, Carolin Freichel, Marc Teleman, Aurelio A.
...
Published in
Frontiers in Chemistry
Metabolic profiling harbors the potential to better understand various disease entities such as cancer, diabetes, Alzheimer’s, Parkinson’s disease or COVID-19. To better understand such diseases and their intricate metabolic pathways in human studies, model animals are regularly used. There, standardized rearing conditions and uniform sampling stra...
Marsh, Kirsty J. Raulo, Aura M. Brouard, Marc Troitsky, Tanya English, Holly M. Allen, Bryony Raval, Rohan Venkatesan, Saudamini Pedersen, Amy B. Webster, Joanne P.
...
Published in
Frontiers in Microbiology
The gut microbiome performs many important functions in mammalian hosts, with community composition shaping its functional role. However, the factors that drive individual microbiota variation in wild animals and to what extent these are predictable or idiosyncratic across populations remains poorly understood. Here, we use a multi-population datas...
Perše, Martina
Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. However, despite numerous promising results, no signif...
Suñer, Clara Sibilio, Annarita Martín, Judit Castellazzi, Chiara Lara Reina, Oscar Dotu, Ivan Caballé, Adrià Rivas, Elisa Calderone, Vittorio Díez, Juana
...
Published in
eLife
Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenylation destabilizes AU-rich element (ARE)-containing mRNAs. However, this mechanism alone cannot expla...
Hunter, A Louise Poolman, Toryn M Kim, Donghwan Gonzalez, Frank J Bechtold, David A Loudon, Andrew S I Iqbal, Mudassar Ray, David W
Published in
Cell reports
The glucocorticoid receptor (GR) is a nuclear receptor critical to the regulation of energy metabolism and inflammation. The actions of GR are dependent on cell type and context. Here, we demonstrate the role of liver lineage-determining factor hepatocyte nuclear factor 4A (HNF4A) in defining liver specificity of GR action. In mouse liver, the HNF4...
Wang, Zhenzhen Zhai, Ziyu Chen, Chunyu Tian, Xuejiao Xing, Zhen Xing, Panfei Yang, Yushun Zhang, Junfeng Wang, Chunming Dong, Lei
...
Published in
eLife
Although fine particulate matter (FPM) in air pollutants and tobacco smoke is recognized as a strong carcinogen and global threat to public health, its biological mechanism for inducing lung cancer remains unclear. Here, by investigating FPM's bioactivities in lung carcinoma mice models, we discover that these particles promote lung tumor progressi...
Kempermann, Gerd
Published in
Frontiers in Neuroscience
Adult hippocampal neurogenesis is a unique and exceptional process in the mammalian brain that in a lifelong and activity-dependent way generates new excitatory principal neurons. A comprehensive view on their function in greater contexts has now emerged, revealing to which extent the hippocampus (and hence brain and mind) depend on these neurons. ...
Balasubramanian, Sandhya Andreani, Matteo Andrade, Júlia Goncalves Saha, Tannishtha Sundaravinayagam, Devakumar Garzón, Javier Zhang, Wenzhu Popp, Oliver Hiraga, Shin-Ichiro Rahjouei, Ali
...
Published in
eLife
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under conditions of replication stress, RIF1 protects nasc...
