The most important organelle in eukaryotic cells is the nucleus. Many processes occurring within the nucleus depend on spatial organization of the nucleus. The spatial organization of the eukaryotic nucleus derives from interactions between its constituents. Both specific interactions, for instance the interactions between a DNA binding protein and...
cum laude graduation (with distinction)
Transcriptomics is part of a family of disciplines focussing on high throughput molecular biology experiments. In the case of transcriptomics, scientists study the expression of genes resulting in transcripts. These transcripts can either perform a biological function themselves or function as messenger molecules containing a copy of the genetic co...
In this thesis we describe different approaches aiding in the utilization of the exponentially growing amount of information available in the life sciences. Briefly, we address two issues in molecular biology, on sequence analysis, and on text mining. The former issue addresses the problem how to determine remote sequence homology especially when t...
Plants require nutrients in order to grow. Most of these are readily available, but a few, like the macronutrients nitrogen and phosphorous, are often limiting growth due to presence in low concentrations or in complexes that cannot be taken up by the plant root. To acquire these macronutrients plants can engage in a mutualistic symbiosis with othe...
Potato (Solanum tuberosum ssp. tuberosum) is the fourth most important food crop with an annual yield of about 300 million tons over the world. The history of the domestication of potato shows that disease-causing agents followed the tracks of potato cultivation in temperate climates across continents, resulting in substantial crop losses. Plants i...
An integrated pilot database was constructed containing administrative, morphological and molecular data as well as pictures of each variety. In spite of some encountered difficulties, it was demonstrated that two laboratories can produce substantially equivalent data and that the molecular data produced is useful as a tool for managing reference c...
The goal in this thesis is to explore the possibility of live imaging of cellular events using fluorescence microscopy in combination with Green Fluorescent Protein (GFP) based reporter constructs in root hairs during theRhizobium-legume interaction. Legumes have the ability to establish anendosymbioticrelationship with soil bacteria of different g...
