Byun, Yuree Choi, Young-Chul Jeong, Yongsu Yoon, Jaeseung Baek, Kwanghee
Published in
Molecules and Cells
Hypoxia plays important roles in cancer progression by inducing angiogenesis, metastasis, and drug resistance. However, the effects of hypoxia on long noncoding RNA (lncRNA) expression have not been clarified. Herein, we evaluated alterations in lncRNA expression in lung cancer cells under hypoxic conditions using lncRNA microarray analyses. Among ...
Spector, Jacob D Wiita, Arun P
Published in
Current protocols in human genetics
DNA copy number variants (CNVs) are routinely evaluated as part of clinical diagnosis in both the prenatal and postnatal genetic settings. Current guidelines for interpreting the potential clinical significance of these CNVs, typically identified by chromosomal microarray, focus entirely on genes localized within the CNV region. However, recent wor...
Zhang, Bing Chu, Wei Wen, Feifei Zhang, Li Sun, Lixia Hu, Baoguang Wang, Jingjing Su, Qingguo Mei, Yanhui Cao, Jingyuan
...
Published in
Frontiers in Oncology
Objective: The roles of long non-coding RNAs (lncRNAs) in the diagnosis of clear cell renal cell carcinoma (ccRCC) are still not well-defined. We aimed to identify differentially expressed lncRNAs and mRNAs in plasma of ccRCC patients and health controls systematically. Methods: Expression profile of plasma lncRNAs and mRNAs in ccRCC patients and h...
Kobayashi, Priscila E. Lainetti, Patrícia F. Leis-Filho, Antonio F. Delella, Flávia K. Carvalho, Marcio Cury, Sarah Santiloni Carvalho, Robson Francisco Fonseca-Alves, Carlos E. Laufer-Amorim, Renée
Published in
Frontiers in Veterinary Science
Canine prostate cancer (PC) presents a poor antitumor response, usually late diagnosis and prognosis. Toceranib phosphate (TP) is a nonspecific inhibitor of receptor tyrosine kinases (RTKs), including vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-KIT. This study aimed to evaluate VEGFR2,...
Ye, Jianzhong Lin, Yishuai Wang, Qing Li, Yating Zhao, Yajie Chen, Lijiang Wu, Qing Xu, Chunquan Zhou, Cui Sun, Yao
...
Published in
Frontiers in Endocrinology
Background Nonalcoholic steatohepatitis (NASH) is rapidly becoming a major chronic liver disease worldwide. However, little is known concerning the pathogenesis and progression mechanism of NASH. Our aim here is to identify key genes and elucidate their biological function in the progression from hepatic steatosis to NASH. Methods Gene expression d...
Aslam, Nazneen Abusharieh, Elham Abuarqoub, Duaa Ali, Dema Al-Hattab, Dana Wehaibi, Suha Al-Kurdi, Ban Jamali, Fatima Alshaer, Walhan Jafar, Hanan
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Published in
Molecular Therapy Oncolytics
Glioblastoma has limited treatment options due to the selective blood-brain barrier. Paracrine factors from mesenchymal stem cells can cross this barrier and exhibited anti-oncogenic potential for glioma stem cells in vitro . These soluble factors can be a tool as a combinatorial therapy for the treatment of glioblastomas.
Ulm, Michael A. Redfern, Tiffany M. Wilson, Ben R. Ponnusamy, Suriyan Asemota, Sarah Blackburn, Patrick W. Wang, Yinan ElNaggar, Adam C. Narayanan, Ramesh
Published in
Journal of Personalized Medicine
Objective: The objective of this study is to identify and validate novel therapeutic target(s) in ovarian cancer. Background: Development of targeted therapeutics in ovarian cancer has been limited by molecular heterogeneity. Although gene expression datasets are available, most of them lack appropriate pair-matched controls to define the alteratio...
Liu, Man Si, Qiufang Ouyang, Songyun Zhou, Zhigang Wang, Meng Zhao, Chunling Yang, Ting Wang, Yulin Zhang, Xue Xie, Wenbo
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Published in
Frontiers in Genetics
The lack of a useful biomarker partly contributes to the increased mortality of non-small cell lung cancer (NSCLC). MiRNAs have become increasingly appreciated in diagnosis of NSCLC. In the present study, we used microarray to screen 2,549 miRNAs in serum samples from the training cohort (NSCLC, n = 10; the healthy, n = 10) to discover differential...
Yokoyama, Hiroyuki Hirai, Takashi Nagata, Tetsuya Enomoto, Mitsuhiro Kaburagi, Hidetoshi Leiyo, Li Motoyoshi, Takayuki Yoshii, Toshitaka Okawa, Atsushi Yokota, Takanori
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Published in
Journal of Pain Research
Purpose Pathological stimuli or injury to the peripheral nervous system can trigger neuropathic pain with common clinical features such as allodynia and hypersensitivity. Although various studies have identified molecules or genes related to neuropathic pain, the essential components are still unclear. Therefore, in this study, we investigated the ...
Mio, Kento Yamanaka, Chiemi Matsuoka, Tsubasa Kobayashi, Toshiki Aoe, Seiichiro
Published in
Nutrients
We evaluated whether intake of β-glucan-rich barley flour affects expression levels of genes related to glucose and lipid metabolism in the ileum, liver, and adipose tissues of mice fed a high-fat diet. C57BL/6J male mice were fed a high-fat diet supplemented with high β-glucan barley, for 92 days. We measured the expression levels of genes involve...
