Jensen, Märit Müller, Christian Schwedhelm, Edzard Arunachalam, Priyadharshini Gelderblom, Mathias Magnus, Tim Gerloff, Christian Zeller, Tanja Choe, Chi-un
Published in
International Journal of Molecular Sciences
l -arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to stroke pathology in both human and mouse studies. However, a comprehensive understanding of the underlying molecular mechanism is lacking. To investigate transcriptional changes in cerebral AGAT metabolism, we applied a transcripto...
Barker, Richard Lombardino, Jonathan Rasmussen, Kai Gilroy, Simon
Published in
Frontiers in Plant Science
Recent advances in the routine access to space along with increasing opportunities to perform plant growth experiments on board the International Space Station have led to an ever-increasing body of transcriptomic, proteomic, and epigenomic data from plants experiencing spaceflight. These datasets hold great promise to help understand how plant bio...
Dong, Ying Yan, Shi Li, Guo-Yan Wang, Min-Nan Leng, Lei Li, Qiang
Published in
Annals of Translational Medicine
Background Diabetes mellitus is becoming a significant health problem with the International Diabetes Federation (IDF) expecting a startling 642 million diabetes patients by 2040. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, is reported to protect against diabetic cardiomyopathy by binding to the receptor, GLP-1R. However, the underlying ...
Wu, Xiao-Min Jin, Cheng Gu, Yuan-Long Chen, Wu-Qiang Zhu, Mao-Qun Zhang, Shuo Zhang, Zhen
Published in
OncoTargets and therapy
Purpose Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally with a poor prognosis. Breakthroughs in the treatment of HCC are urgently needed. This study explored the role of IDNK in the development and progression of HCC. Methods IDNK expression was suppressed using short hairpin (shRNA) in BEL-7404 and Huh-7 cells. The expressi...
Golinski, Marie-Laure Demeules, Mélanie Derambure, Céline Riou, Gaetan Maho-Vaillant, Maud Boyer, Olivier Joly, Pascal Calbo, Sébastien
Published in
Frontiers in Immunology
CD11c+ B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c+ B cells from healthy donors by flow cytometry, microarray analysis, and in vitro functional assays. Here, we report that CD11c+ B cells are a distinct subpopulation of B cells, ...
Bizzarri, Marco Delledonne, Massimo Ferrarini, Alberto Tononi, Paola Zago, Elisa Vittori, Doriano Damiani, Francesco Paolocci, Francesco
Published in
Frontiers in Plant Science
Helianthus tuberosus L., known as the Jerusalem artichoke, is a hexaploid plant species, adapted to low-nutrient soils, that accumulates high levels of inulin in its tubers. Inulin is a fructose-based polysaccharide used either as dietary fiber or for the production of bioethanol. Key enzymes involved in inulin biosynthesis are well known. However,...
Wang, Huan Li, Zhong-Yi Xu, Zu-Hao Chen, Yuan-Lei Lu, Ze-Yi Shen, Dan-Yang Lu, Jie-Yang Zheng, Qi-Ming Wang, Li-Ya Xu, Li-Wei
...
Published in
Journal of Cancer
Purpose Clear cell renal cell carcinoma(ccRCC) is the most common type of renal cell carcinoma. While it is curable when detected at an early stage, some patients presented with advanced disease have poor prognosis. We aimed to identify key genes and miRNAs associated with clinical prognosis in ccRCC. Methods The microarray datasets were obtained f...
Zhou, Dong-Ni Ye, Chun-Sheng Yang, Qing-Qing Deng, Yan-Fei
Published in
Oncology Letters
Non-coding RNAs (ncRNAs) regulate numerous genes and influence the progression of various human diseases, including cancer. The role of regulatory ncRNAs implicated in nasopharyngeal carcinoma (NPC), as well as their target genes, remains unclear. The present study aimed to investigate specific long non-coding (lnc)RNAs, circular RNAs (circRNAs) an...
Damasceno, Samara Gómez-Nieto, Ricardo Garcia-Cairasco, Norberto Herrero-Turrión, Manuel Javier Marín, Faustino Lopéz, Dolores E.
Published in
Frontiers in Neurology
The Wistar Audiogenic Rat (WAR) and the Genetic Audiogenic Seizure Hamster from Salamanca (GASH/Sal) strains are audiogenic epilepsy models, in which seizures are triggered by acoustic stimulation. These strains were developed by selective reproduction and have a genetic background with minimal or no variation. In the current study, we evaluated th...
Wong, Hilary S Wadon, Megan Evans, Alexandra Kirov, George Modi, Neena O'Donovan, Michael C Thapar, Anita
Published in
Journal of medical genetics
The genomic contribution to adverse health sequelae in babies born very preterm (
