Jang, Yurim Moon, Ji Hyun Jeon, Byung Kwan Park, Ho Jin Lee, Hong Jin Lee, Do Yup
Published in
Journal of microbiology and biotechnology
Endocrine-disrupting chemicals (EDCs) are compounds that disturb hormonal homeostasis by binding to receptors. EDCs are metabolized through hepatic enzymes, causing altered transcriptional activities of hormone receptors, and thus necessitating the exploration of the potential endocrine-disrupting activities of EDC-derived metabolites. Accordingly,...
Chen, Ya-Zhen Rong, Wan-Tao Qin, Ying-Can Lu, Lin-Yuan Liu, Jing Li, Ming-Jie Xin, Lei Li, Xiao-Dong Guan, De-Long
Published in
Frontiers in Microbiology
The gut microbiota, a complex ecosystem integral to host wellbeing, is modulated by environmental triggers, including exposure to heavy metals such as chromium. This study aims to comprehensively explore chromium-induced gut microbiota and metabolomic shifts in the quintessential lepidopteran model organism, the silkworm (Bombyx mori). The research...
Ivić, Vedrana Zjalić, Milorad Blažetić, Senka Fenrich, Matija Labak, Irena Scitovski, Rudolf Szűcs, Kálmán Ferenc Ducza, Eszter Tábi, Tamás Bagamery, Fruzsina
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Published in
Frontiers in Endocrinology
Aim/Introduction The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Methods Elderly Sprague–Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and...
Janker, Lukas Schuster, Dina Bortel, Patricia Hagn, Gerhard Meier-Menches, Samuel M Mohr, Thomas Mader, Johanna C Slany, Astrid Bileck, Andrea Brunmair, Julia
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Published in
Journal of Crohn's & colitis
Ulcerative colitis [UC] is a chronic disease with rising incidence and unclear aetiology. Deep molecular phenotyping by multiomics analyses may provide novel insights into disease processes and characteristic features of remission states. UC pathomechanisms were assessed by proteome profiling of human tissue specimens, obtained from five distinct c...
Bedekar, Ashwini Ashok Deewan, Anshu Jagtap, Sujit S. Parker, David A. Liu, Ping Mackie, Roderick I. Rao, Christopher V.
Published in
Frontiers in Microbiology
Methanotrophs play a significant role in methane oxidation, because they are the only biological methane sink present in nature. The methane monooxygenase enzyme oxidizes methane or ammonia into methanol or hydroxylamine, respectively. While much is known about central carbon metabolism in methanotrophs, far less is known about nitrogen metabolism....
Zhang, Guangyuan Zhang, Zhenshan Pei, Yulei Hu, Wei Xue, Yushan Ning, Renli Guo, Xiaomao Sun, Yun Zhang, Qing
Published in
Frontiers in Endocrinology
Introduction We aimed to investigate the feasibility of metabolomics to explain the underlying biological implications of radiomics features obtained from magnetic resonance imaging (MRI) preceding carbon ion radiotherapy (CIRT) in patients with prostate cancer and to further explore the clinical significance of radiomics features on the prognosis ...
Olmedo, Patricio Vidal, Juan Ponce, Excequel Defilippi, Bruno G. Pérez-Donoso, Alonso G. Meneses, Claudio Carpentier, Sebastien Pedreschi, Romina Campos-Vargas, Reinaldo
Grapevine development and ripening are complex processes that involve several biochemical pathways, including fatty acid and lipid metabolism. Fatty acids are essential components of lipids, which play crucial roles in fruit maturation and flavor development. However, the dynamics of fatty acid metabolism in grape flowers and berries are poorly und...
Romano, Andrea Semczuk, Andrzej Tokarz, Janina Rižner, Tea Lanišnik
Published in
Frontiers in Oncology
Xu, Keman Saaoud, Fatma Shao, Ying Lu, Yifan Jiang, Xiaohua Wu, Sheng Sun, Jianxin Fernades Conti, Filipe Martinez, Laisel Vazquez-Padron, Roberto
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Published in
Frontiers in Cardiovascular Medicine
Xie, Jinghui Liu, Mengxiang Gao, Yating Liu, Changan Wu, Fan Tong, Jiabing Li, Zegeng Zhu, Jie
Published in
Frontiers in Pharmacology
In this study, we have employed metabolomics technology in combination with network pharmacology to ascertain the key metabolites and hub genes. The objective was to explore the pathway of Qibai Pingfei Capsule (QBPF) in treating COPD through metabolomics. We identified 96 differential metabolites in the lung tissues of rats belonging to control an...
