Wen, Yong Zhan, Yu Tang, Shiyu Liu, Fang Wu, Rong Kong, Pengfei Li, Qian Tang, Xuegui
Published in
Pharmaceutical biology
Slow transit constipation (STC), the most common type of constipation, seriously affects the life of patients. Zhizhu decoction (ZZD), a traditional Chinese medicine compound, has is effective against functional constipation, but the mechanism is still unclear. This research explores the mechanism of ZZD on STC from the perspective of metabolomics ...
Chen, Xi Bertho, Gildas Caradeuc, Cédric Giraud, Nicolas Lucas-Torres, Covadonga
Published in
Magnetic resonance in chemistry : MRC
NMR is one of the most powerful techniques for the analysis of biological samples in the field of metabolomics. However, the high complexity of fluids, tissues, or other biological materials taken from living organisms is still a challenge for state-of-the-art pulse sequences, thereby limiting the detection, the identification, and the quantificati...
Pitteloud, Camille Defossez, Emmanuel Albouy, Camille Descombes, Patrice Rasmann, Sergio Pellissier, Loïc
Published in
Molecular ecology
Understanding the ecological rules structuring the organization of species interactions is a prerequisite to predicting how ecosystems respond to environmental changes. While the ecological determinants of single networks have been documented, it remains unclear whether network ecological rules are conserved along spatial and environmental gradient...
Jenne, Amy Soong, Ronald Gruschke, Oliver Bastawrous, Monica Monks, Patricia Moloney, Cara Brougham, Dermot F Busse, Falko Bermel, Wolfgang Courtier-Murias, Denis
...
Published in
Magnetic resonance in chemistry : MRC
Superparamagnetic iron oxide nanoparticles (SPIONs) are a contaminant of emerging interest, often used in the medical field as an imaging contrast agent, with additional uses in wastewater treatment and as food additives. Although the use of SPIONs is increasing, little research has been conducted on the toxic impacts to living organisms beyond tra...
Jeppesen, Micah J Powers, Robert
Published in
Magnetic resonance in chemistry : MRC
Metabolomics samples like human urine or serum contain upwards of a few thousand metabolites, but individual analytical techniques can only characterize a few hundred metabolites at best. The uncertainty in metabolite identification commonly encountered in untargeted metabolomics adds to this low coverage problem. A multiplatform (multiple analytic...
Wang, Tianqi Li, Chunpei Ma, Yu Zhou, Hao Du, Xiaonan Li, Yingfeng Long, Shasha Ding, Yifeng Lu, Guoping Chen, Weiming
...
Published in
CNS neuroscience & therapeutics
Status epilepticus (SE) is the most common neurological emergency in pediatric patients. This study aimed to screen for prognostic biomarkers of SE in the cerebrospinal fluid (CSF) using metabolomics. Ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS) was conducted to identify prognostic biomar...
Al Ghadban, Yasmina Du, Yeheng Charnock-Jones, David Garmire, Lana X Smith, Gordon Sovio, Ulla
Objectives To identify and internally validate metabolites predictive of spontaneous preterm birth (sPTB) using multiple machine learning methods and sequential maternal serum samples, and to predict spontaneous early term birth (sETB) using these metabolites. Design Case-cohort design within a prospective cohort study. Setting Cambridge, UK. Popul...
Gallego Murillo, Joan Sebastián (author)...
Production of cultured red blood cells (cRBCs) hold the promise of being a potentially unlimited source of cells that could cover the increasing demand of RBCs for transfusion purposes, while having more control on the quality and safety of the cells compared to the current donor-dependent system. cRBCs could also be used for novel therapies in whi...
Wu, Mengxi Northen, Trent R. Ding, Yezhang
Published in
Frontiers in Plant Science
Plants produce a diverse range of specialized metabolites that play pivotal roles in mediating environmental interactions and stress adaptation. These unique chemical compounds also hold significant agricultural, medicinal, and industrial values. Despite the expanding knowledge of their functions in plant stress interactions, understanding the intr...
Ding, Yezhang Mengxi, Wu Northen, Trent
Plants produce a diverse range of specialized metabolites that play pivotal roles in mediating environmental interactions and stress adaptation. These unique chemical compounds also hold significant agricultural, medicinal, and industrial values. Despite the expanding knowledge of their functions in plant stress interactions, understanding the intr...
