Chen, Jinni Deng, Yao Huang, Baoying Han, Di Wang, Wen Huang, Mengjing Zhai, Chengcheng Zhao, Zhimin Yang, Ren Zhao, Ying
...
Published in
Frontiers in Immunology
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency of international concern, and an effective vaccine is urgently needed to control the pandemic. Envelope (E) and membrane (M) proteins are highly conserved structural proteins among SARS-CoV...
Sun, Qianjin Wei, Xiaona Chen, Wei Zhong, Qian Yan, Zhuanqiang Zhou, Qingfeng Cao, Yongchang Chen, Feng
Published in
Frontiers in Veterinary Science
Mycoplasma synoviae (MS) is a major avian pathogen that causes respiratory damage, infectious synovitis, and arthritis in chickens and causes serious economic losses to the global poultry industry. Despite its significance, knowledge on pathogenicity and pathogenic mechanism of MS is lacking, especially regarding its antigens. Bioinformatic analysi...
congbao kang, qingxin li;
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins. Four of the seven nonstructural proteins, NS2A, NS2B, NS4A and NS4B, are membrane proteins. Unl...
Zhang, Shijian Go, Eden P Ding, Haitao Anang, Saumya Kappes, John C Desaire, Heather Sodroski, Joseph G
Published in
Journal of virology
The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells. The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines. Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can infl...
Ma, Lin Liu, Xin Liu, Qing Jin, Sen Chang, Heng Liu, Haixia
Published in
Frontiers in Physiology
Transient receptor ion potential (TRP) channels are a cluster of non-selective cation channels present on cell membranes. They are important mediators of sensory signals to regulate cellular functions and signaling pathways. Alterations and dysfunction of these channels could disrupt physiological processes, thus leading to a broad array of disorde...
Endres, Jennifer L Chaudhari, Sujata S Zhang, Xinyan Prahlad, Janani Wang, Shu-Qi Foley, Lily A Luca, Sorin Bose, Jeffrey L Thomas, Vinai C Bayles, Kenneth W
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Published in
mBio
The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD). Based on the structural similarities that CidA and LrgA share with bacteriophage holins, we have hypothesized that these proteins function by forming pores within the cytoplasmic membrane. T...
Sunidhi, S. Sacher, Sukriti Atul, Garg, Parth Ray, Arjun
Published in
Frontiers in Molecular Biosciences
ATP Binding Cassette Transporter A1 (ABCA1) plays an integral part in Reverse Cholesterol Transport (RCT) and is critical for maintaining lipid homeostasis. One theory of lipid efflux by the transporter (alternating access) proposes that ABCA1 harbours two different conformations that provide alternating access for lipid binding and release. This i...
Polyiam, Kanokporn Ruengjitchatchawalya, Marasri Mekvichitsaeng, Phenjun Kaeoket, Kampon Hoonsuwan, Tawatchai Joiphaeng, Pichai Roshorm, Yaowaluck Maprang
Published in
Frontiers in Immunology
Porcine epidemic diarrhea virus (PEDV) is the causative agent of PED, an enteric disease that causes high mortality rates in piglets. PEDV is an alphacoronavirus that has high genetic diversity. Insights into neutralizing B-cell epitopes of all genetically diverse PEDV strains are of importance, particularly for designing a vaccine that can provide...
Miller-Vedam, Lakshmi Enid
Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this process. Yet, we have limited understanding of how EMC enables insertion and integrity of diverse clients¬, from tail-anchored to polytopic tr...
Nicolaus, Felix
Proteins are a diverse class of biomolecules that carry out many essential functions across all organisms. They can either be found in aqueous compartments or embedded in biological membranes of the cell and are called soluble or membrane proteins, respectively. Membrane proteins are involved in many essential cellular pathways and account for abou...
