Kushnir, Mark M Nelson, Heather A Doyle, Kelly
Published in
The journal of applied laboratory medicine
The free hormone (FH) hypothesis states that hormone action and the corresponding biological effects are mediated by the unbound (free) fraction of hormone in circulation. The in vivo relationship between protein-bound and FH is complex and dynamic. In most individuals, measurement of total hormone (TH) is usually adequate to reflect the hormone st...
Mahowald, Grace Khaliq, Tahira Basu, Sankha Griggs, David Siegel, Molly Leffert, Lisa Bernstein, Sarah Flood, James G Uljon, Sacha
Published in
The journal of applied laboratory medicine
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is the gold standard for the measurement of fentanyl and norfentanyl (NF) in urine and is favored over immunoassays due to its superior specificity. NF is the principal metabolite of fentanyl found in the urine and is typically present in higher abundance than fentanyl. Thus, the ...
Rauh, David Blankenburg, Claudia Fischer, Tillmann G. Jung, Nicole Kuhn, Stefan Schatzschneider, Ulrich Schulze, Tobias Neumann, Steffen
Published in
Pure and Applied Chemistry
Research data is an essential part of research and almost every publication in chemistry. The data itself can be valuable for reuse if sustainably deposited, annotated and archived. Thus, it is important to publish data following the FAIR principles, to make it findable, accessible, interoperable and reusable not only for humans but also in machine...
D'Alessandro, Margherita Parolin, Carola Patrignani, Silvia Sottile, Gilda Antonazzo, Patrizio Vitali, Beatrice Lanciotti, Rosalba Patrignani, Francesca
Published in
Microorganisms
This study focuses on the isolation of lactobacilli/bifidobacteria from human breast milk and their first characterization, in the perspective to find new probiotic candidates to be included in food products. More specifically, breast-milk-isolated strains demonstrated a very good aptitude to adhere to intestinal cells, in comparison with L. rhamno...
Kravos, Aleksander Žgajnar Gotvajn, Andreja Lavrenčič Štangar, Urška Malinović, Borislav N. Prosen, Helena
Advanced oxidation processes (AOPs) have been introduced to deal with different types of water pollution. They cause effective chemical destruction of pollutants, yet leading to a mixture of transformation by-products, rather than complete mineralization. Therefore, the aim of our study was to understand complex degradation processes induced by dif...
Mao, Yonghong Su, Tao Lin, Tianhai Yang, Hao Zhao, Yang Zhang, Yong Dai, Xinhua
Published in
Frontiers in Chemistry
Glycoproteins are involved in a variety of biological processes. More than one-third of the plasma protein biomarkers of tumors approved by the FDA are glycoproteins, and could improve the diagnostic specificity and/or sensitivity. Therefore, it is of great significance to perform the systematic characterization of plasma N-glycoproteome. In previo...
manis;, cristina
Erythrocytes are highly specialized cells in human body, and their main function is to ensure the gas exchanges, O2 and CO2, within the body. The exposure to microgravity environment leads to several health risks such as those affecting red blood cells. In this work, we investigated the changes that occur in the structure and function of red blood ...
huang;, tingting
Traditional analytical methods for thalassemia screening are needed to process complicated and time-consuming sample pretreatment. In recent decades, ambient mass spectrometry (MS) approaches have been proven to be an effective analytical strategy for direct sample analysis. In this work, we applied ambient MS with wooden-tip electrospray ionizatio...
martínez-martínez;, esther
Wound healing pathologies are an increasing problem in ageing societies. Chronic, non-healing wounds, which cause high morbidity and severely reduce the quality of life of affected individuals, are frequently observed in aged individuals and people suffering from diseases affected by the Western lifestyle, such as diabetes. Causal treatments that s...
xiang;, haitao
Tumor-specific antigens can activate T cell-based antitumor immune responses and are ideal targets for cancer immunotherapy. However, their identification is still challenging. Although mass spectrometry can directly identify human leukocyte antigen (HLA) binding peptides in tumor cells, it focuses on tumor-specific antigens derived from annotated ...
