Atsuta, Yuji Tomizawa, Reiko R. Levin, Michael Tabin, Clifford J.
Published in
Proceedings of the National Academy of Sciences of the United States of America
All cells, including nonexcitable cells, maintain a discrete transmembrane potential ( V mem), and have the capacity to modulate V mem and respond to their own and neighbors’ changes in V mem. Spatiotemporal variations have been described in developing embryonic tissues and in some cases have been implicated in influencing developmental processes. ...
Purushothaman, Sruthi Elewa, Ahmed Seifert, Ashley W
Published in
eLife
Although decades of studies have produced a generalized model for tetrapod limb development, urodeles deviate from anurans and amniotes in at least two key respects: their limbs exhibit preaxial skeletal differentiation and do not develop an apical ectodermal ridge (AER). Here, we investigated how Sonic hedgehog (Shh) and Fibroblast growth factor (...
Cordeiro, Ingrid Rosenburg Kabashima, Kaori Ochi, Haruki Munakata, Keijiro Nishimori, Chika Laslo, Mara Hanken, James Tanaka, Mikiko
Published in
Developmental cell
Amphibians form fingers without webbing by differential growth between digital and interdigital regions. Amniotes, however, employ interdigital cell death (ICD), an additional mechanism that contributes to a greater variation of limb shapes. Here, we investigate the role of environmental oxygen in the evolution of ICD in tetrapods. While cell death...
Castro, João Pl Yancoskie, Michelle N Marchini, Marta Belohlavy, Stefanie Hiramatsu, Layla Kučka, Marek Beluch, William H Naumann, Ronald Skuplik, Isabella Cobb, John
...
Published in
eLife
Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under selection. Here we present a genomic dissection of the Longshanks selection experiment, in which...
Youngworth, Ingrid Delany, Mary E.
Published in
Genes
The chicken wingless -2 ( wg-2 ) mutation is inherited in an autosomal recessive fashion, and the resulting phenotype in mutant ( wg-2 / wg-2 ) individuals is a developmental syndrome characterized by absent wings, truncated legs, craniofacial as well as skin and feather defects, and kidney malformations. Mapping and genotyping established that the...
Youngworth, Ingrid Delany, Mary E
The chicken wingless-2 (wg-2) mutation is inherited in an autosomal recessive fashion, and the resulting phenotype in mutant (wg-2/wg-2) individuals is a developmental syndrome characterized by absent wings, truncated legs, craniofacial as well as skin and feather defects, and kidney malformations. Mapping and genotyping established that the mutati...
Leng, Yue Abdullah, Ammara Wendt, Michael K Calve, Sarah
Published in
Matrix biology : journal of the International Society for Matrix Biology
Hyaluronic acid (HA) is an extracellular matrix (ECM) component that has been shown to play a significant role in regulating muscle cell behavior during repair and regeneration. For instance, ECM remodeling after muscle injury involves an upregulation in HA expression that is coupled with skeletal muscle precursor cell recruitment. However, little ...
Salva, Joanna E Roberts, Ryan R Stucky, Taylor S Merrill, Amy E
Published in
Developmental dynamics : an official publication of the American Association of Anatomists
Bent bone dysplasia syndrome (BBDS), a congenital skeletal disorder caused by dominant mutations in fibroblast growth factor receptor 2 (FGFR2), is characterized by bowed long bones within the limbs. We previously showed that the FGFR2 mutations in BBDS enhance nuclear and nucleolar localization of the receptor; however, exactly how shifts in subce...
Vargesson, Neil
Published in
The Journal of hand surgery, European volume
Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born ...
Oberg, Kerby C
Published in
The Journal of hand surgery, European volume
Recently the International Federation of Societies for Surgery of the Hand replaced the Swanson scheme for classifying congenital upper limb anomalies with the Oberg, Manske, Tonkin (OMT) classification. This review explores the reasons for this change after nearly 50 years of using the Swanson classification. In particular, it documents the state ...
