Wang, G Wang, B Jiang, J
Published in
Genes & development
The Hedgehog (Hh) family of secreted proteins controls many aspects of animal development. In Drosophila, Hh transduces its signal via Cubitus interruptus (Ci), a transcription factor present in two forms: a full-length activator and a carboxy-terminally truncated repressor that is derived from the full-length form by proteolytic processing. The pr...
Galceran, J Fariñas, I Depew, M J Clevers, H Grosschedl, R
Published in
Genes & development
Members of the LEF-1/TCF family of transcription factors have been implicated in the transduction of Wnt signals. However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the mouse do not produce phenotypes that mimic any known Wnt mutation. Here we show that null mutations in both Lef1 and Tcf1, which are expressed in an overlapping pattern ...
Huguet, C. Morrice, D. R. Bouali, F. Vandenbunder, B. Burt, D. W. Abbadie, C.
Published in
Apoptosis
The chicken proto-oncogene c-rel encodes a transcription factor of the Rel/NF-κB family. We have previously shown that c-rel mRNAs accumulate in different types of apoptotic cells of the chick embryo, especially in mesenchymal cells within the four cell death areas of the limb bud: the anterior and posterior necrotic zones, the opaque patch and the...
Torok, MA Gardiner, DM Shubin, NH Bryant, SV
Hox genes play a critical role in the development of the vertebrate axis and limbs, and previous studies have implicated them in the specification of positional identity, the control of growth, and the timing of differentiation. Axolotl limbs offer an opportunity to distinguish these alternatives because the sequence of skeletal differentiation is ...
Jiang, R Lan, Y Chapman, H D Shawber, C Norton, C R Serreze, D V Weinmaster, G Gridley, T
Published in
Genes & development
The Notch signaling pathway is a conserved intercellular signaling mechanism that is essential for proper embryonic development in numerous metazoan organisms. We have examined the in vivo role of the Jagged2 (Jag2) gene, which encodes a ligand for the Notch family of transmembrane receptors, by making a targeted mutation that removes a domain of t...
Sherman, L Wainwright, D Ponta, H Herrlich, P
Published in
Genes & development
Signals from the apical ectodermal ridge (AER) of the developing vertebrate limb, including fibroblast growth factor-8 (FGF-8), can maintain limb mesenchymal cells in a proliferative state. We report here that a specific CD44 splice variant is crucial for the proliferation of these mesenchymal cells. Epitopes carried by this variant colocalize temp...
Zou, H Wieser, R Massagué, J Niswander, L
Published in
Genes & development
The bone morphogenetic proteins (BMPs), TGF beta superfamily members, play diverse roles in embryogenesis, but how the BMPs exert their action is unclear and how different BMP receptors (BMPRs) contribute to this process is not known. Here we demonstrate that the two type I BMPRs, BMPR-IA and BMPR-IB, regulate distinct processes during chick limb d...
Monkley, S.J. Delaney, S.J. Pennisi, D.J. Christiansen, J.H. Wainwright, B.J.
Wnt genes have been implicated in a range of developmental processes in the mouse including the patterning of the central nervous system and limbs. Reported here for the first time is the expression of Wnt2 in the early heart field of 7.5-8.5 dpc (days post-coitum) mouse embryos, making Wnt2 a potentially useful gene marker for the early stages of ...
Abe, Nobuhiro
Blanco, M J Alberch, P
Published in
Evolution; international journal of organic evolution
In this paper, after a comparative analysis of the development of Triturus marmoratus, we explore the existence of caenogenetic events and their ontogenetic and phylogenetic consequences. The adult morphology of the Triturus marmoratus limb, in terms of number and spatial arrangement of skeletal elements, agrees with the general pattern of urodeles...
