Published in International Review of Neurobiology
This chapter explains aggression and central neurotransmitters. The term “aggression” indicates a particular oriented behavior, which leads to, or appears to an observer to lead to, the damage or destruction of some goal. Some ethologists have used the term “agonistic behavior” to describe various sorts of behavior that occur during conflict and ha...
Published in Biochemical and Biophysical Research Communications
Intravenous administration of synthetic human pancreatic polypeptide (hPP) with 36 amino acid residues significantly decreased immunoreactive somatostatin levels in both hepatic portal and systemic plasma in anesthetized rats. The effect of hPP on plasma somatostatin levels is acute. The results suggest that hPP may have a role in controlling somat...
Published in Biochemical and Biophysical Research Communications
An alkyl ether analog of phosphatidylcholine was prepared from choline plasmalogen of fresh beef heart by reducing the alk-1-enyl moiety to an alkyl group and by hydrolyzing the sn-2 acyl moiety and replacing it with an acetoyl group. The basis for preparing and testing this compound resulted from experience with antihypertensive lipids derived fro...
Published in Biochemical Pharmacology
The i.v. administration of tubercidin, an analog of adenosine, in a single dose of 45 mg/kg caused death in about 90% of B10D2F 1 mice so treated. Serum and urine analysis, as well as histological examination of tissues, related the lethality of tubercidin to hepatic injury, which was markedly reduced when mice were treated with the inhibitor of nu...
Published in Biochemical Pharmacology
The comparison of the anti-inflammatory properties (carrageenan paw edema in the rat) of exogenous Cu SODs from various species and human Mn SOD administered at doses corresponding to clinical schedules, shows that human and bovine Cu SOD are fully active, whereas rat Cu SOD and Mn SOD are inefficient. This difference does not correspond to the sim...
Published in Biochemical and Biophysical Research Communications
Evidence from three types of experiments indicates that platelet activating factor (PAF) is an important mediator of endotoxin-induced hypotension in rats. a) Endotoxin infusion stimulates the time-dependent appearance of PAF in the blood. b) PAF infusion results immediately (
Published in British journal of clinical pharmacology
1 The pharmacokinetic characteristics and bioavailability of isoxicam were investigated in healthy male volunteers following various routes of administration. Plasma concentrations were determined up to 96 or 120 h following each administration using a selective h.p.l.c. method. 2 Twelve subjects received an i.v. and an i.m. injection of 150 mg and...
Published in Biochemical and Biophysical Research Communications
Using a direct monitoring system for catecholamine (CA) secretion into the adrenal vein, we have demonstrated that capsaicin (CAP) evokes CA secretion from the adrenal medulla of pentobarbital-anesthetized rats. A significant increase in epinephrine (E) secretion was seen in rats infused with CAP (200 μg/kg, i.v.) without a detectable lag after the...
Published in Biochemical Pharmacology
Intraperitoneal administration of glutathione isopropyl ester to fasted, male NMRI mice dose dependently increased the glutathione concentration in various organs. Administration of 1 g kg glutathione isopropyl ester led to the following increases: liver 166%; lung 164%; heart 121% after 4 hr; and brain 133% after 6 hr. Spleen, kidney, muscle, seru...
Published in Biochemical and Biophysical Research Communications
Septic shock is a life-threatening condition that results from exposure to bacterial endotoxin. It is manifested by cardiovascular collapse and mediated by the release of cytokines such as tumor necrosis factor. Some of these cytokines cause the release of vasoactive substances. In the present study, administration of 40 μg/kg of bacterial endotoxi...
