Current epilepsy surgery planning protocol determines the seizure onset zone (SOZ) through resource-intensive, invasive monitoring of ictal events. Recently, we have reported that Granger Causality (GC) maps produced from analysis of interictal iEEG recordings have potential in revealing SOZ. In this study, we investigate GC maps’ network connectiv...
Jedním ze stále nevysvětlených dějů v lidském mozku je dynamika pozornosti. S pozorností interní je silně spjata neuronová síť Default Mode network (DMN), naopak s popisem externí pozornosti neuronová síť Central Executive network. Změny při přepínaní těchto sítí byly vyhodnocovány díky záznamu z intrakraniálního EEG u farmakorezistivních pacientů ...
Published in Frontiers in Behavioral Neuroscience
Dual-tasking is extremely prominent nowadays, despite ample evidence that it comes with a performance cost: the Dual-Task (DT) cost. Neuroimaging studies have established that tasks are more likely to interfere if they rely on common brain regions, but the precise neural origin of the DT cost has proven elusive so far, mostly because fMRI does not ...
Published in Frontiers in Neurology
Multimodal image integration (MMII) is a promising tool to help delineate the epileptogenic zone (EZ) in patients with medically intractable focal epilepsies undergoing presurgical evaluation. We report here the detailed methodology of MMII and an overview of the utility of MMII at the Cleveland Clinic Epilepsy Center from 2014 to 2018, exemplified...
Published in Frontiers in Neurology
A central challenge in today's care of epilepsy patients is that the disease dynamics are severely under-sampled in the currently typical setting with appointment-based clinical and electroencephalographic examinations. Implantable devices to monitor electrical brain signals and to detect epileptic seizures may significantly improve this situation ...
Published in Brain communications
Brain network models derived from graph theory have the potential to guide functional neurosurgery, and to improve rates of post-operative seizure freedom for patients with epilepsy. A barrier to applying these models clinically is that intracranial EEG electrode implantation strategies vary by centre, region and country, from cortical grid & strip...
Published in Brain : a journal of neurology
We describe the spatiotemporal course of cortical high-gamma activity, hippocampal ripple activity and interictal epileptiform discharges during an associative memory task in 15 epilepsy patients undergoing invasive EEG. Successful encoding trials manifested significantly greater high-gamma activity in hippocampus and frontal regions. Successful cu...
Published in Neurologia medico-chirurgica
Epilepsy is a chronic condition that affects about 50 million individuals worldwide. While its challenges are profound, there are increasing instances where antiepileptic drugs (AEDs) fail to provide relief to epileptic manifestations. For these pharmacoresistant cases, epilepsy surgery often is an effective route for treatment. However, the comple...
Published in Epilepsy currents
Published in Explore (New York, N.Y.)
Meditation has been deemed a miracle cure for a wide range of neurological disorders. However, it is unclear whether meditation practice would be beneficial for patients suffering from epilepsy. Here we report on the comparison of the effects of focused-attention meditation and a control task on electroencephalographic (EEG) activity in a patient u...
