In an attempt to find the neonicotinoid insecticides, twenty novel dihydropyridine derivatives were designed, &ldquo / green&rdquo / synthesized via one pot facile three-component reaction and evaluated for their bioactivities against Tetranychus cinnabarinus, Myzus persicae, Brevicoryne brassicae, Fusarium oxysporum f. sp. vasinfectum, Magnaporthe...
Egerolizini so družina majhnih (13-20 kDa) β / -strukturiranih proteinov, ki jih najdemo pri predstavnikih evkariontov in prokariontov. Večina egerolizinov interagira z membranskimi lipidi, pri določenih pa so odkrili lastnost porotvornosti v interakciji s proteinskim partnerjem. Bakterije, ki imajo v operonu poleg gena za egerolizin še gen za prot...
Spider venoms are complex mixtures of biologically active components with potentially interesting applications for drug discovery or for agricultural purposes. The spider Phoneutria nigriventer is responsible for a number of envenomations with sometimes severe clinical manifestations in humans. A more efficient treatment requires a comprehensive kn...
Spider venoms are complex mixtures of biologically active components with potentially interesting applications for drug discovery or for agricultural purposes. The spider Phoneutria nigriventer is responsible for a number of envenomations with sometimes severe clinical manifestations in humans. A more efficient treatment requires a comprehensive kn...
Published in Insect molecular biology
The diamondback moth, Plutella xylostella, has developed extremely high levels of resistance to chlorantraniliprole and other classes of insecticides in the field. As microRNAs (miRNAs) play important roles in various biological processes through gene regulation, we examined the miRNA profile of P. xylostella in response to chlorantraniliprole expo...
Published in Interdisciplinary Toxicology
Pesticides are used in agriculture and in domestic pest control. Dichlorvos, an organophosphate, is a predominant pesticide used in domestic insect control in developing countries. Acute and prolonged exposure may lead to death, genotoxic, neurological, reproductive, carcinogenic, immunological, hepatic, renal, respiratory, metabolic, dermal and ot...
Published in Journal of agricultural and food chemistry
Chemical pesticides and their formulation ingredients can have unintended effects on microbes associated with plants and plant pests. These effects can be due to direct effects on the microbes or to effects on crops or weeds that subsequently affect the microbes. In addition to fungicides, some insecticides, herbicides, and formulation compounds ar...
Published in Biological Reviews of the Cambridge Philosophical Society
Durable crop protection is an essential component of current and future food security. However, the effectiveness of pesticides is threatened by the evolution of resistant pathogens, weeds and insect pests. Pesticides are mostly novel synthetic compounds, and yet target species are often able to evolve resistance soon after a new compound is introd...
Published in Proceedings of the National Academy of Sciences of the United States of America
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles , Aedes , and Culex mosquitoes and Phlebotomus sand flies after feeding on a drug-supplemented blood me...
Published in Aquatic toxicology (Amsterdam, Netherlands)
Over the last few decades, the pyrethroid insecticide bifenthrin has been increasingly employed for pest control in urban and agricultural areas, putting humans and wildlife at increased risk of exposure. Exposures to nanomolar (nM) concentrations of bifenthrin have recently been reported to alter calcium oscillations in rodent neurons. Neuronal ca...
