Barnes, Alex Spizzo, Paul Mountifield, Réme
Published in
Internal medicine journal
Steroid exposure has been associated with poorer outcomes following colectomy in acute severe ulcerative colitis (ASUC). Our centre aimed to examine the effect of prolonged oral corticosteroid therapy immediately prior to admission on the likelihood of requiring rescue therapy along with predictors of intravenous corticosteroid failure on day one o...
Munsel, Erin J. Bryan, Peter J. Binstadt, Bryce A. Bullock, Danielle Correll, Colleen K. Downs, Elissa M. Hobday, Patricia M. Larson-Nath, Catherine Sudel, Boris Vehe, Richard K.
...
Published in
The Journal of Pediatric Pharmacology and Therapeutics : JPPT
OBJECTIVES To compare infusion reaction rates between rapid infliximab (REMICADE, Janssen Biotech Inc) infusions and previous standard 2- to 3-hour infusions; additionally, to assess patient satisfaction and reduction in chair time associated with rapid infliximab infusions. METHODS Pediatric rheumatology and gastroenterology patients receiving mai...
Lu, Jiajing Tang, Suwei Yu, Ning Yi, Xuemei Li, Ying
Published in
The Journal of International Medical Research
Uveitis is considered a relatively rare but serious ocular complication of psoriasis. We report the first successful treatment of severe noninfectious uveitis with secukinumab in a 70-year-old woman with erythrodermic psoriasis and psoriatic arthritis. Anti-tumor necrosis factor (TNF) agents were administered for 5 years for the treatment of erythr...
Lu, Zhongxing Wang, Fen Lv, Haitao
Published in
Experimental and Therapeutic Medicine
The present study aimed to review the relevant studies in order to determine the efficacy of infliximab (IFX) in the treatment of Kawasaki disease (KD). The relevant studies were retrieved using the PubMed, Cochrane and Embase databases. Key sources in the literature were reviewed; all articles published by July 2019 were considered for inclusion. ...
Molinelli, Elisa Sapigni, Claudia Campanati, Anna Brisigotti, Valerio Offidani, Annamaria
Published in
Expert opinion on drug metabolism & toxicology
Hidradenitis suppurativa is a chronic, relapsing, debilitating inflammatory dermatologic disease of the terminal hair follicles at intertriginous sites clinically characterized by painful inflammatory nodules, abscesses, draining sinus tracts, and dermal fibrosis. The management of hidradenitis suppurativa is a challenge and usually consists of bot...
Pedersen, Lise Szecsi, Pal Bela Johansen, Per Birger Bjerrum, Poul Jannik
Published in
Biologics : Targets & Therapy
Purpose Treatment of rheumatic diseases with tumor necrosis factor inhibitors leads to improved clinical outcomes. Therapeutic drug monitoring (TDM) may assist in guiding clinical decisions. This study investigates the impact of TDM on clinical outcome, decision-making and biologics cost expenditure. Patients and Methods In a retrospective observat...
Pierre, Nicolas Baiwir, Dominique Huynh-Thu, Vân Anh Mazzucchelli, Gabriel Smargiasso, Nicolas De Pauw, Edwin Bouhnik, Yoram Laharie, David Colombel, Jean-Frédéric Meuwis, Marie-Alice
...
Published in
Gut
A subset of Crohn's disease (CD) patients experiences mid/long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients. New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined therapy (antimetabolite and infliximab) and stable clinical remiss...
Mikail, Maria Wilson, Aze
Published in
SAGE Open Medical Case Reports
Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that is highly associated with pathergy in the setting of trauma or surgery, systemic disease, or may be idiopathic. Herein, we present the case of a 68-year-old female with ulcerative colitis who underwent a subtotal colectomy with an end-ileostomy and presented post-operatively with larg...
Moorkens, Evelien Barcina Lacosta, Teresa Vulto, Arnold G. Schulz, Martin Gradl, Gabriele Enners, Salka Selke, Gisbert Huys, Isabelle Simoens, Steven
Published in
Pharmaceuticals
Drug budget and prescription control measures are implemented regionally in Germany, meaning that the uptake of pharmaceuticals, including biosimilars, can vary by region. We examine regional market dynamics of tumor necrosis factor alpha (TNFα) inhibitor originators and biosimilars in Germany and studied the influence of biosimilar policies on the...
Kanis, Shannon Linda Modderman, Sanne Escher, Johanna C Erler, Nicole Beukers, Ruud de Boer, Nanne Bodelier, Alexander Depla, Annekatrien C T M Dijkstra, Gerard van Dijk, Anne-Baue Ruth Margaretha
...
Published in
Gut
The aim of this study was to describe the long-term health outcomes of children born to mothers with inflammatory bowel disease (IBD) and to assess the impact of maternal IBD medication use on these outcomes. We performed a multicentre retrospective study in The Netherlands. Women with IBD who gave birth between 1999 and 2018 were enrolled from 20 ...
