OBJECTIVE¿We investigated whether circulating adipokine concentrations can be altered by lifestyle intervention according to general recommendations in subjects at risk for diabetes as well as the potential of leptin, adiponectin, and resistin as biomarkers for lifestyle-induced improvements in glucose metabolism and insulin resistance. RESEARCH DE...
Published in Journal of Retail & Leisure Property
This paper deals with the assessment of the rental value of shell condition pub restaurants where located on either retail or leisure parks. Should rental valuation be by reference to either direct floor area comparison or by the profits method? In the virtual absence of market lettings of such properties how is the limited comparable evidence from...
The primary goal of a phase I trial is to find the maximally tolerated dose (MTD) of a treatment. The MTD is usually defined in terms of a tolerable probability, q* of toxicity. Our objective is to find the highest dose with toxicity risk that does not exceed q*, a criterion that is often desired in designing phase I trials. This criterion differs ...
The primary goal of a phase I trial is to find the maximally tolerated dose (MTD) of a treatment. The MTD is usually defined in terms of a tolerable probability, q*, of toxicity. Our objective is to find the highest dose with toxicity risk that does not exceed q*, a criterion that is often desired in designing phase I trials. This criterion differs...
The purpose of a phase I trial in cancer is to determine the level (dose) of the treatment under study that has an acceptable level of adverse effects. Although substantial progress has recently been made in this area using parametric approaches, the method that is widely used is based on treating small cohorts of patients at escalating doses until...
In the past, the otter was present in rivers where fish were abundant. At present, it is rare in the Walloon Region. However, other populations are increasing in France (Loire) and in Germany. It is gaining basins where the distance between us is less and less for Belgium. Detailed maps ( 1/10000 th) of the potential otter day-resting places are p...
This report addresses the performance measurement of railway enterprises from two perspectives. First, the on-going separation process of European railway companies into infrastructure companies and operating companies allows a clearer identification of stakeholders and their expectations, according to which performance targets should consequently ...
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