Matrai, Amanda B. Kastetter, Bryn Cooley, Brian C.
Published in
Journal of Cardiovascular Development and Disease
Background: The timing for initiation of effective antithrombotic therapy relative to the onset of arterial thrombosis may influence outcomes. This report investigates the hypothesis that early administration of heparin anticoagulation relative to the onset of thrombotic occlusion will effect a reduction in occlusion. Methods: A standard rat model ...
Ao, Qiang Wang, Shilin He, Qing Ten, Hirotomo Oyama, Kenichi Ito, Akihiro He, Jing Javed, Rabia Wang, Aijun Matsuno, Akira
...
Published in
ACS applied materials & interfaces
Bone morphogenetic proteins (BMPs) have been used to promote bone formation in many clinical scenarios. However, the BMPs are inherently unstable in vivo and therefore need to be combined with carriers for controlled delivery. In this study, an innovative and efficient fibrin glue/fibronectin/heparin (FG/Fn/Hep)-based delivery system was developed ...
Law, Jonathan P Pickup, Luke Townend, Jonathan N Ferro, Charles J
Published in
Clinical Medicine
Chronic kidney disease (CKD) is a global health problem affecting up to 14% of the adult population in developed countries. On the basis of current guidelines, patients with CKD will often fulfil criteria for both short-term and long-term anticoagulation. Paradoxically, patients with CKD are not only at a higher risk of thrombosis, they are also at...
CAMILLO, FRANCIS X. MITCHELL, SEAN M.
Published in
International Journal of Spine Surgery
Background Cervical spine blunt trauma patients with the presence of a cerebrovascular injury may be given initiation of heparin anticoagulation treatment prior to necessary surgical stabilization. Literature regarding the safety and efficacy of these procedures while a patient is on active anticoagulation is limited, requiring further investigatio...
Kocak, Fatma Z. Talari, Abdullah C.S. Yar, Muhammad Rehman, Ihtesham U.
Published in
International Journal of Molecular Sciences
Biomaterials that promote angiogenesis are required for repair and regeneration of bone. In-situ formed injectable hydrogels functionalised with bioactive agents, facilitating angiogenesis have high demand for bone regeneration. In this study, pH and thermosensitive hydrogels based on chitosan (CS) and hydroxyapatite (HA) composite materials loaded...
Aizawa, Hachidai Kawabata, Hideo Sato, Atsushi Masuki, Hideo Watanabe, Taisuke Tsujino, Tetsuhiro Isobe, Kazushige Nakamura, Masayuki Nakata, Koh Kawase, Tomoyuki
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Published in
Biomedicines
It is generally accepted that citrate or the A-form of acid-citrate-dextrose (ACD-A) are suitable for preparing platelet-rich plasma (PRP) for regenerative therapy. However, this is based on evidence from blood transfusions and not from regenerative medicine. Thus, we examined the effects of anticoagulants, such as ACD-A, ethylenediaminetetraacetic...
marson, domenico laurini, erik aulic, suzana fermeglia, maurizio pricl, sabrina
Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical applications, nanovectors-assisted gene delivery being a prime example. This review work summar...
Mycroft-West, Courtney J. Devlin, Anthony J. Cooper, Lynsay C. Procter, Patricia Miller, Gavin J. Fernig, David G. Guerrini, Marco Guimond, Scott E. Lima, Marcelo A. Yates, Edwin A.
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Published in
Neural Regeneration Research
The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target, the primary neuronal β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1). The anticoagulant activity of heparin has, however...
Wiedermann, Christian J.
Published in
Acute Medicine & Surgery
The use of antithrombin and thrombomodulin to restore impaired anticoagulant pathways in septic coagulopathy has been shown to significantly increase the resolution rate of disseminated intravascular coagulation. In KyberSept and SCARLET, two large, international, randomized controlled trials in patients with sepsis, these anticoagulants have not s...
Akula, Srinivas Paivandy, Aida Fu, Zhirong Thorpe, Michael Pejler, Gunnar Hellman, Lars
Published in
Cells
Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at external and internal surfaces of the body where they act in the first line of defense. MCs are found in all studied vertebrates and have also been identified in tunicates, an early chordate. To obtain a detailed insight into the biology of MCs, here we analyze...
