Garcia-Garcia, Hector M Adamo, Marianna Soud, Mohamad Yacob, Omar Picchi, Andrea Sardella, Gennaro Frigoli, Enrico Limbruno, Ugo Rigattieri, Stefano Diletti, Roberto
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Published in
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Residual stent strut thrombosis after primary percutaneous coronary intervention (PCI), negatively affects myocardial perfusion, may increase stent thrombosis risk, and it is associated with neointima hyperplasia at follow-up. To study the effectiveness of any bivalirudin infusion versus unfractionated heparin (UFH) infusion in reducing residual st...
Conzelmann, Carina Müller, Janis A Perkhofer, Lukas Sparrer, Konstantin Mj Zelikin, Alexander N Münch, Jan Kleger, Alexander
Published in
Clinical medicine (London, England)
Here, we advocate a highly favourable opportunity for the treatment of COVID-19 disease by repurposing a long-serving medical agent with an excellent history of clinical use, namely heparin. Heparin is best known as an anticoagulant, but it also exhibits direct antiviral activity against many enveloped viruses and has anti-inflammatory activity. Th...
Clausen, Thomas Mandel Sandoval, Daniel R Spliid, Charlotte B Pihl, Jessica Perrett, Hailee R Painter, Chelsea D Narayanan, Anoop Majowicz, Sydney A Kwong, Elizabeth M McVicar, Rachael N
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We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site. Both ACE2 and heparin can bind independently to spike protein in vitro, and a terna...
Falter, Florian MacDonald, Stephen Matthews, Claire Kemna, Evelien Cañameres, José Besser, Martin
Published in
Journal of cardiothoracic and vascular anesthesia
The activated clotting time (ACT) is used worldwide to confirm safe heparin anticoagulation for cardiopulmonary bypass. For the present study, the performances of 2 commonly used ACT devices were compared with each other and with anti-Xa levels throughout the surgical procedure in order to understand whether they can be used interchangeably. Prospe...
Salamanna, Francesca Landini, Maria Paola Fini, Milena
Published in
Therapeutic Advances in Hematology
Smith, Kelly Krajewski, Kristin C Krajewski, Michael P
Published in
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
There are increasing reports in the literature of high rates of coagulopathy and venous thromboembolism (VTE) among hospitalized patients with coronavirus disease 2019 (COVID-19). Understanding of these abnormalities is continually evolving, but these conditions may pose a risk to patients with COVID-19 beyond the risk typically seen in critically ...
Sorgi, Meghan W Roach, Erin Bauer, Seth R Bass, Stephanie Militello, Michael Welch, Sarah Lam, Simon Reddy, Anita J Torbic, Heather
Published in
Journal of pharmacy practice
The direct comparison of twice daily (BID) and thrice daily (TID) dosing of subcutaneous low dose unfractionated heparin (LDUH) for venous thromboembolism (VTE) prophylaxis in a mixed inpatient population is not well-studied. This study evaluated the effectiveness and safety of BID compared to TID dosing of LDUH for prevention of VTE. Retrospective...
Bett, Cyrus Andrews, Omozusi Asher, David M. Pilant, Teresa Keire, David Gregori, Luisa
Published in
Emerging Infectious Diseases
US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnorma...
Kashiwakura, Y Kojima, H Kanno, Y Hashiguchi, M Kobata, T
Published in
Clinical and experimental immunology
Heparin is a widely used anti-coagulant that enhances anti-thrombin (AT) activity. However, heparin also suppresses immune and inflammatory responses in various rodent models and clinical trials, respectively. The mechanism by which heparin suppresses immune responses is unclear. The effect of heparin on regulatory T cells (Tregs ) in allogeneic im...
Wigmosta, Tara B Popat, Ketul C Kipper, Matt J
Published in
Journal of biomedical materials research. Part A
Incomplete osseointegration is primary cause of failure for orthopedic implants. New biomaterials that present stable signals promoting osteogenesis could reduce failure rates of orthopedic implants. In this study bone morphogenetic protein-2 (BMP-2) was delivered from titania nanotubes (Nt) modified with chitosan/heparin polyelectrolyte multilayer...