Pellionisz, A.
Published in
Progress in Brain Research
Quantitation and mathematization of experimental neuroscience leads to the establishment of brain theory. Progress is spearheaded by system neuroscience and sensorimotor research, yielding computational paradigms of neural nets, to be utilized by neurocomputing and neurobotics. A mathematical concept and formalism using natural (general) coordinate...
Urban, N N Barrionuevo, G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The synapse made by hippocampal mossy fibers onto pyramidal neurons of hippocampal area CA3 displays a form of long-term potentiation (LTP) that is independent of the activation of NMDA receptors. Considerable controversy exists as to whether the induction of mossy fiber LTP requires postsynaptic activation and, thus, whether mossy fiber LTP is Heb...
Wuarin, J P Dudek, F E
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mossy fiber sprouting has been proposed to lead to new excitatory connections between dentate granule cells, which in turn cause electrographic seizures. We tested this hypothesis in hippocampal slices from rats made epileptic-by kainate injections. The Timm's histological method revealed intense staining of the inner molecular layer in slices from...
Clark, B A Farrant, M Cull-Candy, S G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The assumption that synaptic and extrasynaptic glutamate receptors are similar underpins many studies that have sought to relate the behavior of channels in excised patches to the macroscopic properties of the EPSC. We have examined this issue for NMDA receptors in cerebellar granule cells, the small size of which allows the opening of individual s...
Jones, A Korpi, E R McKernan, R M Pelz, R Nusser, Z Mäkelä, R Mellor, J R Pollard, S Bahn, S Stephenson, F A
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cerebellar granule cells express six GABAA receptor subunits abundantly (alpha1, alpha6, beta2, beta3, gamma2, and delta) and assemble various pentameric receptor subtypes with unknown subunit compositions; however, the rules guiding receptor subunit assembly are unclear. Here, removal of intact alpha6 protein from cerebellar granule cells allowed ...
Miyata, T Nakajima, K Mikoshiba, K Ogawa, M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cerebellar Purkinje cells are generated in the ventricular zone, migrate outward, and finally form a monolayer in the cortex. In reeler mice, however, most Purkinje cells cluster abnormally in subcortical areas. Reelin, the candidate reeler gene product recognized by the CR-50 monoclonal antibody, is concentrated in a cortical zone along which Purk...
Peng, L Martin-Vasallo, P Sweadner, K J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
There are multiple isoforms of the Na,K-ATPase in the nervous system, three isoforms of the alpha subunit, and at least two of the beta subunit. The alpha subunit is the catalytic subunit. The beta subunit has several roles. It is required for enzyme assembly, it has been implicated in neuron-glia adhesion, and the experimental exchange of beta sub...
Hu, Z Yuri, K Ozawa, H Lu, H Kawata, M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Although apoptotic cellular degeneration has been reported to be extremely rapid with the use of in vitro models, the time needed to clear apoptotic neurons in the in vivo brain is unknown. In this study we used a simple morphological approach to solve this problem. Four days after adrenalectomy (ADX), all of the operated rats morphologically displ...
Chen, C Regehr, W G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Increases in cAMP have been shown previously to enhance the strength of the granule cell to Purkinje cell synapse. We have examined the mechanisms underlying this enhancement in rat cerebellar brain slices. Elevation of cAMP levels by forskolin increased synaptic currents in a dose-dependent manner. Fluorometric calcium measurements revealed that f...
Dittman, J S Regehr, W G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
High levels of activity at a synapse can lead to spillover of neurotransmitter from the synaptic cleft. This extrasynaptic neurotransmitter can diffuse to neighboring synapses and modulate transmission via presynaptic receptors. We studied such modulation at the synapse between granule cells and Purkinje cells in rat cerebellar slices. Brief tetani...
