Ona Jodar, Tiffany Lage-Rupprecht, Vanessa Abraham, Nixon M. Rose, Christine R. Egger, Veronica
Published in
Frontiers in Synaptic Neuroscience
In the vertebrate olfactory bulb (OB), axonless granule cells (GC) mediate self- and lateral inhibitory interactions between mitral/tufted cells via reciprocal dendrodendritic synapses. Locally triggered release of GABA from the large reciprocal GC spines occurs on both fast and slow time scales, possibly enabling parallel processing during olfacto...
Marín, Milagros Sáez-Lara, María José Ros, Eduardo Garrido, Jesús A.
Published in
Frontiers in Cellular Neuroscience
Biologically relevant large-scale computational models currently represent one of the main methods in neuroscience for studying information processing primitives of brain areas. However, biologically realistic neuron models tend to be computationally heavy and thus prevent these models from being part of brain-area models including thousands or eve...
Furlan, Sandra Campione, Marina Murgia, Marta Mosole, Simone Argenton, Francesco Volpe, Pompeo Nori, Alessandra
Published in
Frontiers in Neuroanatomy
Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zebrafish adult brain with emphasi...
Chou, Zane Z. Yu, Gene J. Berger, Theodore W.
Published in
Frontiers in Computational Neuroscience
Biological realism of dendritic morphologies is important for simulating electrical stimulation of brain tissue. By adding point process modeling and conditional sampling to existing generation strategies, we provide a novel means of reproducing the nuanced branching behavior that occurs in different layers of granule cell dendritic morphologies. I...
Fore, Taylor R. Taylor, Benjamin N. Brunel, Nicolas Hull, Court
Published in
The Journal of Neuroscience
Sensorimotor integration in the cerebellum is essential for refining motor output, and the first stage of this processing occurs in the granule cell layer. Recent evidence suggests that granule cell layer synaptic integration can be contextually modified, although the circuit mechanisms that could mediate such modulation remain largely unknown. Her...
Straub, Isabelle Witter, Laurens Eshra, Abdelmoneim Hoidis, Miriam Byczkowicz, Niklas Maas, Sebastian Delvendahl, Igor Dorgans, Kevin Savier, Elise Bechmann, Ingo
...
Cerebellar granule cells (GCs) make up the majority of all neurons in the vertebrate brain, but heterogeneities among GCs and potential functional consequences are poorly understood. Here, we identified unexpected gradients in the biophysical properties of GCs in mice. GCs closer to the white matter (inner-zone GCs) had higher firing thresholds and...
Cameron, Starr Lopez, Ariana Glabman, Raisa Abrams, Emily Johnson, Shawn Field, Cara Gulland, Frances M D Buckmaster, Paul S
Published in
The Journal of comparative neurology
One in 26 people develop epilepsy and in these temporal lobe epilepsy (TLE) is common. Many patients display a pattern of neuron loss called hippocampal sclerosis. Seizures usually start in the hippocampus but underlying mechanisms remain unclear. One possibility is insufficient inhibition of dentate granule cells. Normally parvalbumin-immunoreacti...
Eshra, Abdelmoneim Hirrlinger, Petra Hallermann, Stefan
Published in
Frontiers in cellular neuroscience
Environmental enrichment for rodents is known to enhance motor performance. Structural and molecular changes have been reported to be coupled with an enriched environment, but functional alterations of single neurons remain elusive. Here, we compared mice raised under control conditions and an enriched environment. We tested the motor performance o...
Ibata, Keiji Kono, Maya Narumi, Sakae Motohashi, Junko Kakegawa, Wataru Kohda, Kazuhisa Yuzaki, Michisuke
Published in
Neuron
Synapse formation is achieved by various synaptic organizers. Although this process is highly regulated by neuronal activity, the underlying molecular mechanisms remain largely unclear. Here we show that Cbln1, a synaptic organizer of the C1q family, is released from lysosomes in axons but not dendrites of cerebellar granule cells in an activity- a...
Narayanan, Sriram Thirumalai, Vatsala
Published in
Current opinion in physiology
The cerebellum with its layered structure and stereotyped and conserved connectivity has long puzzled neurobiologists. While it is well established that the cerebellum functions in regulating balance, motor coordination and motor learning, how it achieves these end results has not been very clear. Recent technical advances have made it possible to ...
