Wang, Xin-Tai Zhou, Lin Cai, Xin-Yu Xu, Fang-Xiao Xu, Zhi-Heng Li, Xiang-Yao Shen, Ying
Published in
Frontiers in Cell and Developmental Biology
The cerebellum is conceptualized as a processor of complex movements. Many diseases with gene-targeted mutations, including Fahr’s disease associated with the loss-of-function mutation of meningioma expressed antigen 6 (Mea6), exhibit cerebellar malformations, and abnormal motor behaviors. We previously reported that the defects in cerebellar devel...
Consalez, G. Giacomo Goldowitz, Daniel Casoni, Filippo Hawkes, Richard
Published in
Frontiers in Neural Circuits
Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first consider the formation of the upper rhombic lip, from which all granule cell precursors arise, and the way by which the upper rhombic lip generates the external gr...
Ona Jodar, Tiffany Lage-Rupprecht, Vanessa Abraham, Nixon M. Rose, Christine R. Egger, Veronica
Published in
Frontiers in Synaptic Neuroscience
In the vertebrate olfactory bulb (OB), axonless granule cells (GC) mediate self- and lateral inhibitory interactions between mitral/tufted cells via reciprocal dendrodendritic synapses. Locally triggered release of GABA from the large reciprocal GC spines occurs on both fast and slow time scales, possibly enabling parallel processing during olfacto...
Marín, Milagros Sáez-Lara, María José Ros, Eduardo Garrido, Jesús A.
Published in
Frontiers in Cellular Neuroscience
Biologically relevant large-scale computational models currently represent one of the main methods in neuroscience for studying information processing primitives of brain areas. However, biologically realistic neuron models tend to be computationally heavy and thus prevent these models from being part of brain-area models including thousands or eve...
Furlan, Sandra Campione, Marina Murgia, Marta Mosole, Simone Argenton, Francesco Volpe, Pompeo Nori, Alessandra
Published in
Frontiers in Neuroanatomy
Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zebrafish adult brain with emphasi...
Chou, Zane Z. Yu, Gene J. Berger, Theodore W.
Published in
Frontiers in Computational Neuroscience
Biological realism of dendritic morphologies is important for simulating electrical stimulation of brain tissue. By adding point process modeling and conditional sampling to existing generation strategies, we provide a novel means of reproducing the nuanced branching behavior that occurs in different layers of granule cell dendritic morphologies. I...
Fore, Taylor R. Taylor, Benjamin N. Brunel, Nicolas Hull, Court
Published in
The Journal of Neuroscience
Sensorimotor integration in the cerebellum is essential for refining motor output, and the first stage of this processing occurs in the granule cell layer. Recent evidence suggests that granule cell layer synaptic integration can be contextually modified, although the circuit mechanisms that could mediate such modulation remain largely unknown. Her...
Straub, Isabelle Witter, Laurens Eshra, Abdelmoneim Hoidis, Miriam Byczkowicz, Niklas Maas, Sebastian Delvendahl, Igor Dorgans, Kevin Savier, Elise Bechmann, Ingo
...
Published in
eLife
The timing of movements such as posture, balance and speech are coordinated by a region of the brain called the cerebellum. Although this part of the brain is small, it contains a huge number of tiny nerve cells known as granule cells. These cells make up more than half the nerve cells in the human brain. But why there are so many is not well under...
Cameron, Starr Lopez, Ariana Glabman, Raisa Abrams, Emily Johnson, Shawn Field, Cara Gulland, Frances M D Buckmaster, Paul S
Published in
The Journal of comparative neurology
One in 26 people develop epilepsy and in these temporal lobe epilepsy (TLE) is common. Many patients display a pattern of neuron loss called hippocampal sclerosis. Seizures usually start in the hippocampus but underlying mechanisms remain unclear. One possibility is insufficient inhibition of dentate granule cells. Normally parvalbumin-immunoreacti...
Eshra, Abdelmoneim Hirrlinger, Petra Hallermann, Stefan
Published in
Frontiers in cellular neuroscience
Environmental enrichment for rodents is known to enhance motor performance. Structural and molecular changes have been reported to be coupled with an enriched environment, but functional alterations of single neurons remain elusive. Here, we compared mice raised under control conditions and an enriched environment. We tested the motor performance o...
