Kadotani, H Hirano, T Masugi, M Nakamura, K Nakao, K Katsuki, M Nakanishi, S
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
NMDA receptors consist of two distinct classes of subunits. The NR1 subunit possesses all properties of the NMDA receptor-channel complex, whereas four NR2 subunits (NR2A-2D) potentiate and differentiate NMDA receptor responses by heteromeric assemblies with NR1. The mRNAs for the five NMDA receptor subunits are expressed in the cerebellum in a dis...
Luk, W P Zhang, Y White, T D Lue, F A Wu, C Jiang, C G Zhang, L Moldofsky, H
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Interleukin-1 (IL-1) is a pleotrophic cytokine implicated in a variety of central activities, including fever, sleep, ischemic injury, and neuromodulatory responses, such as neuroimmune, and neuroendocrine interactions. Although accumulating evidence is available regarding the expression pattern of this cytokine, its receptors in the CNS, and its m...
Dahel, Khair Al-deen Al-Saffar, Najat M. Flayeh, Khawola A.
Published in
Neurochemical Research
High level of polyamine oxidase activity is detected in sera of depressed as well as in schizophrenic patients. ECT treatment of depressed and schizophrenic patients reduced significantly the level of polyamine oxidase activity in their sera. After ECT treatment, clinically improved depressed and schizophrenic subjects were found to have sera polya...
Yamamoto, Mutsuya Wada, Norio Kitabatake, Yasuji Watanabe, Dai Anzai, Masayuki Yokoyama, Minesuke Teranishi, Yutaka Nakanishi, Shigetada
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
We developed a novel technique that allowed reversible suppression of glutamatergic neurotransmission in the cerebellar network. We generated two lines of transgenic mice termed Tet and TeNT mice and crossed the two transgenic lines to produce the Tet/TeNT double transgenic mice. In the Tet mice, the tetracycline-controlled reverse activator (rtTA)...
Maneuf, Y P Blake, R Andrews, N A McKnight, A T
Published in
British journal of pharmacology
Recently, we showed that gabapentin can inhibit a facilitatory effect of substance P (SP) on K(+)-evoked glutamate release in rat trigeminal slices (Maneuf et al., 2001), and we have now examined the effect of gabapentin on glutamate release in the trigeminal slice from the streptozotocin (STZ)-treated rat. 1. At 4 weeks following STZ treatment (50...
Diana, Marco A Marty, Alain
Published in
Int J Radiat Oncol Biol Phys
Depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE) are two related forms of short-term synaptic plasticity of GABAergic and glutamatergic transmission, respectively. They are induced by calcium concentration increases in postsynaptic cells and are mediated by the release of a retrograde...
Rancillac, A. Barbara, J.G.
In the cerebellum, dendritic inhibition of Purkinje cells (PCs) is mediated by stellate cells (SCs). These inhibitory interneurons are critically involved in the cerebellar network; they control the timing and firing frequency of PCs, the only output cells of the cerebellar cortex. However, the underlying properties of parallel fiber (PF) to SC exc...
Morishima, Yosuke Miyakawa, Tsuyoshi Furuyashiki, Tomoyuki Tanaka, Yasuhiro Mizuma, Hiroshi Nakanishi, Shigetada
Published in
Proceedings of the National Academy of Sciences of the United States of America
Extensive pharmacological studies have recently emerged indicating that group 2 metabotropic glutamate receptors (mGluRs) comprising mGluR2 and mGluR3 subtypes are associated with several neurological and psychiatric disorders. mGluR2 is widely distributed both presynaptically and postsynaptically in a variety of neuronal cells, but the physiologic...
Rancillac, A Barbara, J G
Published in
Journal of neuroscience research
In the cerebellum, dendritic inhibition of Purkinje cells (PCs) is mediated by stellate cells (SCs). These inhibitory interneurons are critically involved in the cerebellar network; they control the timing and firing frequency of PCs, the only output cells of the cerebellar cortex. However, the underlying properties of parallel fiber (PF) to SC exc...
Fernández de Sevilla, David Rodrigo-Angulo, Margarita Nuñez, Angel Buño, Washington
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Somatosensory information, conveyed through the gracilis nucleus (GN), is regulated by descending corticofugal (CF) glutamatergic fibers. In addition, the GN receives cholinergic inputs with still unclear source and functional significance. Using both the in vitro slice and intracellular recording with sharp and patch electrodes and in vivo extrace...
