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with genomics as keyword

Expanded geographic distribution for two Legionella pneumophila sequence types of clinical concern

Published in mSphere

Since the 1990s, cases of Legionnaires’ disease (LD) attributed to a pair of closely related Legionella pneumophila variants, ST213 and ST222, have increased in the U.S. Furthermore, between 2002 and 2021, ST222 caused at least five outbreaks of LD in the U.S., while ST213 has not been linked to any U.S. outbreak. We wanted to understand how the ra...

A new selective force driving metabolic gene clustering

Published in mSystems

The formation of clusters of functionally related genes in microbial genomes has puzzled microbiologists since their discovery. Here, we suggest that replication, and the copy number variations due to the replisome passage, might play a role in the process through a perturbation in metabolite homeostasis. We provide theoretical support to this hypo...

Virulence perspective genomic research unlocks the secrets of Rhizoctonia solani associated with banded sheath blight in...

Published in Frontiers in Plant Science

Introduction Banded sheath blight (Bsb) disease, caused by Rhizoctonia solani, is an emerging problem in barnyard millet cultivation. One of the significant goals of pathogenomic research is to identify genes responsible for pathogenicity in the fungus. Methods A virulence profiling-based approach was employed and six R. solani isolates were collec...

Epigenetic modulation of fungal pathogens: a focus on Magnaporthe oryzae

Published in Frontiers in Microbiology

Epigenetics has emerged as a potent field of study for understanding the factors influencing the effectiveness of human disease treatments and for identifying alternations induced by pathogens in host plants. However, there has been a paucity of research on the epigenetic control of the proliferation and pathogenicity of fungal plant pathogens. Fun...

Current Technologies in Snake Venom Analysis and Applications

This comprehensive review explores the cutting-edge advancements in snake venom research, focusing on the integration of proteomics, genomics, transcriptomics, and bioinformatics. Highlighting the transformative impact of these technologies, the review delves into the genetic and ecological factors driving venom evolution, the complex molecular com...

Targeted discovery of polyketides with antioxidant activity through integrated omics and cocultivation strategies

Published in Applied and Environmental Microbiology

Polyketides, particularly those with complex structures, are crucial in drug development and synthesis. This study introduces a novel approach to discover new polyketides by integrating genomics, metabolomics, and cocultivation strategies. By combining genome mining, building block molecular networks, and coculturing techniques, we identified and i...

Cannabinoid hyperemesis syndrome: genetic susceptibility to toxic exposure

Published in Frontiers in Toxicology

Cannabinoid hyperemesis syndrome presents as a complex of symptoms and signs encompassing nausea, vomiting, abdominal pain, and hot water bathing behavior, most typically in a heavy cannabis user. Its presentation is frequently associated with hypothalamic-pituitary-adrenal axis activation with stress and weight loss. Recent investigation has ident...

Microbial biodiversity and bioprospecting in polar ecosystems in the genomics era

Published in Frontiers in Microbiology

Deciphering the molecular heterogeneity of intermediate- and (very-)high-risk non–muscle-invasive bladder cancer using m...

Published in Frontiers in Oncology

Bladder cancer (BC) is the most common malignancy of the urinary tract. About 75% of all BC patients present with non-muscle-invasive BC (NMIBC), of which up to 70% will recur, and 15% will progress in stage and grade. As the recurrence and progression rates of NMIBC are strongly associated with some clinical and pathological factors, several risk ...