Mihori, Saki Nichols, Frank Provatas, Anthony Matz, Alyssa Zhou, Beiyan Blesso, Christopher N. Panier, Hunter Daddi, Lauren Zhou, Yanjiao Clark, Robert B.
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Published in
Frontiers in Immunology
How the microbiome regulates responses of systemic innate immune cells is unclear. In the present study, our purpose was to document a novel mechanism by which the microbiome mediates crosstalk with the systemic innate immune system. We have identified a family of microbiome Bacteroidota-derived lipopeptides—the serine-glycine (S/G) lipids, which a...
Wang, Yuxuan Fondell, Joseph D. Zhong, Guangming Fan, Huizhou
Published in
Microbiology Spectrum
Cui, Danni Song, Yin Jiang, Weihao Ye, Han Wang, Shipeng Yuan, Li Liu, Bailin
Published in
Frontiers in Plant Science
Growth-regulating factors (GRFs) are transcription factors that play a pivotal role in plant growth and development. This study identifies 12 Solanum tuberosum GRF transcription factors (StGRFs) and analyzes their physicochemical properties, phylogenetic relationships, gene structures and gene expression patterns using bioinformatics. The StGRFs ex...
Li, Hui-Liang Wang, Ying Guo, Dong Zhu, Jia-Hong Wang, Yu Dai, Hao-Fu Peng, Shi-Qing
Published in
Frontiers in Plant Science
Rubber tree (Hevea brasiliensis) is reproduced by bud grafting for commercial planting, but significant intraclonal variations exist in bud-grafted clones. DNA methylation changes related to grafting may be partly responsible for intraclonal variations. In the current study, whole-genome DNA methylation profiles of grafted rubber tree plants (GPs) ...
Omran, Thura Akrem Tunsjø, Hege Smith Jahanlu, David Brackmann, Stephan Andreas Bemanian, Vahid Sæther, Per Christian
Published in
Frontiers in Immunology
Background Colorectal cancer (CRC) is a significant health issue, with notable incidence rates in Norway. The immune response plays a dual role in CRC, offering both protective effects and promoting tumor growth. This research aims to provide a detailed screening of immune-related genes and identify specific genes in CRC and adenomatous polyps with...
Wallen, Zachary D. Ko, Heidi Nesline, Mary K. Hastings, Stephanie B. Strickland, Kyle C. Previs, Rebecca A. Zhang, Shengle Pabla, Sarabjot Conroy, Jeffrey Jackson, Jennifer B.
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Published in
Frontiers in Immunology
Introduction Younger patients with non-small cell lung cancer (NSCLC) (
Lin, Miin Jo, Se-Young Luebeck, Jens Chang, Howard Wu, Sihan Mischel, Paul Bafna, Vineet
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, is incompletely under...
Yang, Fang Fan, Jinhua Yang, Runxiang Cun, Yupeng
Published in
Frontiers in Immunology
Introduction Chemoresistance constitutes a prevalent factor that significantly impacts thesurvival of patients undergoing treatment for smal-cell lung cancer (SCLC). Chemotherapy resistance in SCLC patients is generally classified as primary or acquired resistance, each governedby distinct mechanisms that remain inadequately researched. Methods In ...
Xue, Yuanqing Friedl, Verena Ding, Hongxu Wong, Christopher Stuart, Joshua
The cellular components of tumors and their microenvironment play pivotal roles in tumor progression, patient survival, and the response to cancer treatments. Unveiling a comprehensive cellular profile within bulk tumors via single-cell RNA sequencing (scRNA-seq) data is crucial, as it unveils intrinsic tumor cellular traits that elude identificati...
Ratiu, Attila Cristian Ionascu, Adrian Ecovoiu, Alexandru Al.
Published in
Frontiers in Genetics
Drosophila melanogaster has been at the forefront of genetic studies and biochemical modeling for over a century. Yet, the functions of many genes are still unknown, mainly because no phenotypic data are available. Herein, we present the first evidence data regarding the particular molecular and other quantifiable phenotypes, such as viability and ...
