Xie, Zi-Wei He, Yue Feng, Yu-Xin Wang, Xiao-Hong
Published in
Frontiers in Endocrinology
Background Endometriosis (EM) is a prevalent gynecological disorder frequently associated with irregular menstruation and infertility. Programmed cell death (PCD) is pivotal in the pathophysiological mechanisms underlying EM. Despite this, the precise pathogenesis of EM remains poorly understood, leading to diagnostic delays. Consequently, identify...
Chen, Ying Li, Bingxun Xu, Hongxuan Wu, Lin
Published in
Frontiers in Pharmacology
Background: Mitochondrial dysfunction is one of the important patho-mechanisms in the development of atrial fibrillation (AF) with underidentified genetic pathophysiology. Methods: Summarized data of methylation, expression and protein abundance levels of mitochondria-related genes were obtained from corresponding studies, respectively. Genes relat...
Wang, Yin-Hua Ye, Xing Zhao, Bi-Yao Wang, Wen-Jing Zhou, Zheng-Feng Zhang, Xiang-Qian Du, Juan Song, Jian-Ling Huang, Xiao-Ling Ouyang, Kun-Xi
...
Published in
Frontiers in Plant Science
Introduction Members of the plant-specific B3 transcription factor superfamily play crucial roles in various plant growth and developmental processes. Despite numerous valuable studies on B3 genes in other species, little is known about the B3 superfamily in pearl millet. Methods and results Here, through comparative genomic analysis, we identified...
Fujimoto, Yukari Nakazawa, Naotaka
Published in
Frontiers in Cell and Developmental Biology
The cell has multiple mechanisms for sensing and responding to dynamic changes in the mechanical environment. In the process, intracellular signaling is activated to modulate gene expression. Recent studies have shown that multifunctional signaling molecules that link intracellular force and gene expression are important for understanding cellular ...
Luo, Hongbiao Luo, Wei Ding, Ning Zhu, Huimin Lai, Jiahui Tang, Qingzhu He, Yongheng
Published in
Frontiers in Pharmacology
Objectives Fibroleukin (FGA) and NOTCH3 are vital in both exercise-induced muscle adaptation and colon adenocarcinoma (COAD) progression. This study aims to elucidate the roles of FGA and NOTCH3 in phenotypic variations of striated muscle induced by exercise and in COAD development. Additionally, it seeks to evaluate the prognostic significance of ...
Zajacova, A. Mackova, M. Halloran, K. Gauthier, P. Balko, J. Guney, M. Rakita, D. Svorcova, M. Kolarik, J. Vachtenheim, J. Jr
...
Published in
Transplant International
Zhang, Si-Pei Zhang, Jie Wang, Qing-Hao Ye, Yang Zhang, Dai-Zhen Liu, Qiu-Ning Tang, Bo-Ping Dai, Li-Shang
Published in
Frontiers in Immunology
Iron-binding proteins, known as ferritins, play pivotal roles in immunological response, detoxification, and iron storage. Despite their significance to organisms, little is known about how they affect the immunological system of the red swamp crayfish (Procambarus clarkii). In our previous research, one ferritin subunit was completely discovered a...
Mukhtar, Saima Choudhry, Nakhshab Saeed, Saqib Hanif, Asif Gondal, Aamir J. Yasmin, Nighat
Published in
Frontiers in Pharmacology
Background: Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on patients and healthcare systems. Spirometry is the most widely used test to diagnose the disease; however, a surrogate marker is required to predict the disease pattern and progression. Objectives: The aim of the current study was to explore the association of ...
Liu, Sha Chen, Ting Li, Xin Cui, Junjun Tian, Yinshuai
Published in
Frontiers in Genetics
The Epidermal Patterning Factor/EPF-like (EPF/EPFL) family encodes a specific type of secreted protein in plants and plays an important role in plant growth and development, especially in the process of morphogenesis. To investigate the characteristics of EPF/EPFL gene family members and their regulatory functions in stomatal development of Populus...
Chen, Dorothy Dong, Ruocheng Kachuri, Linda Hoffmann, Thomas Jiang, Yu Berndt, Sonja Shelley, John Schaffer, Kerry Machiela, Mitchell Freedman, Neal
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Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide association study (GWAS) summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. ...
