Genoomonderzoek bij landbouwhuisdieren levert een belangrijke bijdrage aan een verhoogd fundamenteel wetenschappelijk inzicht in het biologisch functioneren van dier en mens en maakt het in toenemende mate mogelijk om binnen de fokkerij dieren te selecteren op basis van bekende variaties in het erfelijk materiaal (DNA)
The aim of the research presented in this thesis was to aid in the international chicken genome mapping effort. To this purpose, a significant contribution was made to the construction of the chicken whole-genome BAC-based physical map (presented in Chapter A). An important aspect of this construction was the integration of the genetic and physical...
Samenvatting van de voordracht te houden op 30 november 2005 tijdens de Najaarsvergadering van de KNPV (Koninklijke Nederlandse Plantenziektekundige Vereniging). Onderzoek naar de mogelijke toepasbaarheid van een baculovirus uit de Turkse mot voor biologische bestrijding van de rups van deze mot
Apple is generally considered as a healthy food, but 2-3% European people can not eat this fruit because it provokes allergy reaction. Four classes of apple allergen genes have been identified, they are Mal d 1, Mal d 2, Mal d 3 and Mal d 4 . This thesis focuses on the genomic characterization of these candidate genes on the apple genome by linkage...
De behoefte aan snelle, eenduidige technieken voor detectie van Meloidogyne soorten neemt toe. Dergelijke technieken zijn nodig voor het goed kunnen uitvoeren van onderzoek, resistentie-management, ontwerp van vruchtwisselingschema's en voor inspectie van geoogste gewassen en grondmonsters. DNA technieken bieden aantrekkelijke oplossingen voor de p...
The aim of this thesis was the implementation and application of SNP markers in animal breeding and genetics. The emphasis was on the analysis of fatness traits in pigs, in particular of the imprinted QTL region on SSC2p. Several aspects of the implemetation of SNP markers in genetic analysis oflivestock wereaddressed, including SNP discovery metho...
To date, aquaculture accounts for 25% of the total world supply of (shell)fish for human consumption, a relative contribution that is expected to increase with time. The increased global demand for (shell)fish has lead to a further intensification of aquaculture with the inevitable result that fish become disposed to stress and diseases. An importa...
Homologous recombination and sister chromatid cohesion play important roles in the maintenance of genome integrity and the fidelity of chromosome segregation in mitosis and meiosis. Within the living cell, the integrity of the DNA is threatened by various factors that cause DNA-lesions, of which DNA double-strand breaks (DSBs) are considered partic...
Cowpea aphid-borne mosaic potyvirus causes severe yield losses in cowpea, an important legume crop in semi-arid regions of Africa. We have elucidated the genomic sequence of the virus and subsequently focused our attention on the so-called helper component-proteinase (HC-Pro), a virus-encoded multifunctional protein with roles in different steps of...
