Opejin, Adeleye Surnov, Alexey Misulovin, Ziva Pherson, Michelle Gross, Cindy Iberg, Courtney A Fallahee, Ian Bourque, Jessica Dorsett, Dale Hawiger, Daniel
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Published in
Cell reports
Various processes induce and maintain immune tolerance, but effector T cells still arise under minimal perturbations of homeostasis through unclear mechanisms. We report that, contrary to the model postulating primarily tolerogenic mechanisms initiated under homeostatic conditions, effector programming is an integral part of T cell fate determinati...
Wang, Ying Yu, Zizhong Zhou, Yue Zhu, Yun Wang, Jinhui Fu, Junmei Yuan, Yang Chen, Shan Wang, Yanjun Yu, Wenting
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Published in
Aging (Albany NY)
It has been reported that allergen dosage can impact the differentiation of dendritic cells (DCs)-mediated T cells. However, the mechanisms of such dose-dependent differentiation are poorly understood. In this study, bone marrow-derived immature DCs stimulated with Ovalbumin (OVA) of different concentrations (0, 10, 100, 1000, 10000μg/ml, respectiv...
Atkinson, Victoria Khattak, Adnan Haydon, Andrew Eastgate, Melissa Roy, Amitesh Prithviraj, Prashanth Mueller, Christian Brignone, Chrystelle Triebel, Frederic
Published in
Journal for Immunotherapy of Cancer
Background To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein, in combination with the programmed cell death-1 (PD-1) antagonist pembrolizumab. Methods The study was divided into two parts; parts A and B, where part A was the dose escalation part an...
Adamczewski, Zbigniew Stasiołek, Mariusz Zygmunt, Arkadiusz Śliwka, Przemysław W. Wieczorek-Szukała, Katarzyna Lewiński, Andrzej
Published in
Frontiers in Endocrinology
Multiple cellular and humoral components of the immune system play a significant role in the physiology and pathophysiology of various organs including the thyroid. On the other hand, both thyroid hormones and thyroid-stimulating hormone (TSH) have been shown to exert immunoregulatory activities, which are difficult to assess independently in vivo ...
Jones, Iris K. A. Haese, Nicole N. Gatault, Philippe Streblow, Zachary J. Andoh, Takeshi F. Denton, Michael Streblow, Cassilyn E. Bonin, Kiley Kreklywich, Craig N. Burg, Jennifer M.
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Published in
Pathogens
Cytomegalovirus (CMV) establishes persistent, latent infection in hosts, causing diseases in immunocompromised patients, transplant recipients, and neonates. CMV infection modifies the host chemokine axis by modulating chemokine and chemokine receptor expression and by encoding putative chemokine and chemokine receptor homologues. The viral protein...
Kim, Woo Sik Choi, DaeSeong Park, Ji Min Song, Ha-Yeon Seo, Ho Seong Lee, Dong-Eun Byun, Eui-Baek
Published in
Vaccines
Cancer cells can secrete exosomes under various stressful conditions, whose functions are involved in the delivery of various biologically active materials into host cells and/or modulation of host immune responses. Therefore, an improved understanding of the immunological interventions that stress-induced tumor exosomes have may provide novel ther...
Klein, Martin Colas, Luc Cheminant, Marie-Aude Brosseau, Carole Sauzeau, Vincent Magnan, Antoine Bouchaud, Grégory
Published in
Frontiers in Immunology
Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by more than 90% of HDM-allergic patients. In mouse models, all asthma-related features can be prevented ...
Zhu, Bo Zhu, Lihua Xia, Lin Xiong, Yuyun Yin, Qing Rui, Ke
Published in
Frontiers in Immunology
Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process tha...
Lee, Kijeong Han, Mi-Ryung Yeon, Ji Woo Kim, Byoungjae Kim, Tae Hoon
Published in
International Journal of Molecular Sciences
Dendritic cells (DCs) play critical roles in atopic diseases, orchestrating both innate and adaptive immune systems. Nevertheless, limited information is available regarding the mechanism through which DCs induce hyperresponsiveness in patients with allergies. This study aims to reveal novel genetic alterations and future therapeutic target molecul...
Nakao, Momoko Sugaya, Makoto Fujita, Hideki Miyagaki, Tomomitsu Morimura, Sohshi Shibata, Sayaka Asano, Yoshihide Sato, Shinichi
Published in
International Journal of Molecular Sciences
Emerging evidence has demonstrated that Toll-like receptors (TLRs) are associated with autoimmune diseases. In this study, we investigated the role of TLR2 in psoriasis using imiquimod-induced psoriasis-like dermatitis. Although TLR2 signaling is known to play a critical role in the induction of proinflammatory cytokines by immune cells, such as de...
