Hübbe, Mie Linder Jæhger, Ditte Elisabeth Andresen, Thomas Lars Andersen, Mads Hald
Published in
Frontiers in Immunology
Adoptive cell therapy (ACT), based on treatment with autologous tumor infiltrating lymphocyte (TIL)-derived or genetically modified chimeric antigen receptor (CAR) T cells, has become a potentially curative therapy for subgroups of patients with melanoma and hematological malignancies. To further improve response rates, and to broaden the applicabi...
Hosomi, Koji Shibata, Naoko Shimoyama, Atsushi Uto, Tomoya Nagatake, Takahiro Tojima, Yoko Nishino, Tomomi Takeyama, Haruko Fukase, Koichi Kiyono, Hiroshi
...
Published in
Frontiers in Microbiology
Lymphoid-tissue–resident commensal bacteria (LRCs), including Alcaligenes faecalis , are present in intestinal lymphoid tissue including the Peyer’s patches (PPs) of mammals and modulate the host immune system. Although LRCs can colonize within dendritic cells (DCs), the mechanisms through which LRCs persist in DCs and the symbiotic relationships b...
Bonomo, Adriana C. Pinto-Mariz, Fernanda Riederer, Ingo Benjamim, Claudia F. Butler-Browne, Gillian Mouly, Vincent Savino, Wilson
Published in
Frontiers in Physiology
Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal muscle regeneration. Although one component of the innate immunity, the macrophage, has been extens...
Silva-Cardoso, Sandra C. Tao, Weiyang Angiolilli, Chiara Lopes, Ana P. Bekker, Cornelis P. J. Devaprasad, Abhinandan Giovannone, Barbara van Laar, Jaap Cossu, Marta Marut, Wioleta
...
Published in
Frontiers in Immunology
Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset and extent of fibrosis development in multiple inflammatory and fibrotic diseases. Here, we used monocyte-derived cells as...
Yaseen, Mahmoud Mohammad Abuharfeil, Nizar Mohammad Darmani, Homa Daoud, Ammar
Published in
Open Biology
Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status. In fact, the immune system is naturally equipped with immunoregulatory cells that can limit immune activation and inflammation...
Protti, Maria Pia De Monte, Lucia
Published in
Frontiers in Immunology
The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods. Human TSLP is mostly expressed in epithelial cells, among which are keratinocytes as well as stromal cells such as fibroblasts and immune cells. Hum...
Gutierrez-Hoffmann, Maria G. O'Meally, Robert N. Cole, Robert N. Tiniakou, Eleni Darrah, Erika Soloski, Mark J.
Published in
Frontiers in Medicine
The MHC class II antigen processing and presentation pathway has evolved to derive short amino acid peptides from proteins that enter the endocytic pathway, load them onto MHC class II molecules and display them on the surface of antigen presenting cells for recognition by CD4+ T cells. Under normal circumstances, peptides bound to MHC class II mol...
Imperato, Jessica Nancy Xu, Daqi Romagnoli, Pablo A. Qiu, Zhijuan Perez, Pedro Khairallah, Camille Pham, Quynh-Mai Andrusaite, Anna Bravo-Blas, Alberto Milling, Simon W. F.
...
Published in
Frontiers in Immunology
While immune responses have been rigorously examined after intravenous Listeria monocytogenes ( Lm ) infection, less is understood about its dissemination from the intestines or the induction of adaptive immunity after more physiologic models of foodborne infection. Consequently, this study focused on early events in the intestinal mucosa and drain...
Lundgren, Sebastian Micke, Patrick Elebro, Jacob Heby, Margareta Hrynchyk, Ina Nodin, Björn Leandersson, Karin Mezheyeuski, Artur Jirström, Karin
Published in
Frontiers in Immunology
Background The clinical management of pancreatic and other periampullary neoplasms remains challenging. In contrast to other cancer types, immunotherapies are largely ineffective, and the reason for the deprived immune response and the immune inhibiting cellular composition is only fragmentarily understood. The aim of this study was to comprehensiv...
Hoober, J. Kenneth van Vliet, Sandra J. Dudziak, Diana Eggink, Laura L.
Published in
Frontiers in Immunology
