Park, Sang Chul Shim, Dahee Kim, Hongmin Bak, Yeeun Choi, Da Yeon Yoon, Joo-Heon Kim, Chang-Hoon Shin, Sung Jae
Published in
International Journal of Molecular Sciences
Dendritic cells (DCs) are the main mediators of Th2 immune responses in allergic asthma, and Fms-like tyrosine kinase 3 ligand (Flt3L) is an important growth factor for the development and homeostasis of DCs. This study identified the DC populations that primarily cause the initiation and development of allergic lung inflammation using Fms-like tyr...
Wu, Jiachang Zhao, Renli Dai, Jingxing Lai, Guohua Khan, Asmat Ullah Yu, Xiao Wu, Sha Ouyang, Jun Sang, Hongxun
Published in
Molecular Medicine Reports
Dendritic cells release bioactive exosomes involved in immune regulation. Long non-coding RNAs (lncRNAs) are implicated in a number of immunoregulatory mechanisms. However, the roles of lncRNAs in dendritic cell-derived exosomes remain to be elucidated. The present study aimed to investigate the roles of lncRNAs in exosomes derived from mature and ...
Soto, Manuel Ramírez, Laura Solana, José Carlos Cook, Emma C. L. Hernández-García, Elena Charro-Zanca, Sara Redondo-Urzainqui, Ana Reguera, Rosa M. Balaña-Fouce, Rafael Iborra, Salvador
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Published in
Frontiers in Immunology
Unveiling the protective immune response to visceral leishmaniasis is critical for a rational design of vaccines aimed at reducing the impact caused by this fatal, if left untreated, vector-borne disease. In this study we sought to determine the role of the basic leucine zipper transcription factor ATF-like 3 (Batf3) in the evolution of infection w...
Kirshtein, Arkadz Akbarinejad, Shaya Hao, Wenrui Le, Trang Su, Sumeyye Aronow, Rachel A. Shahriyari, Leili
Published in
Journal of Clinical Medicine
Every colon cancer has its own unique characteristics, and therefore may respond differently to identical treatments. Here, we develop a data driven mathematical model for the interaction network of key components of immune microenvironment in colon cancer. We estimate the relative abundance of each immune cell from gene expression profiles of tumo...
Marshall, Payton L Nagy, Nadine Kaber, Gernot Barlow, Graham L Ramesh, Amrit Xie, Bryan J Linde, Miles H Haddock, Naomi L Lester, Colin A Tran, Quynh-Lam
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Published in
Matrix biology : journal of the International Society for Matrix Biology
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prev...
Scheenstra, Maaike R Martínez-Botía, Patricia Acebes-Huerta, Andrea Brouwer, Rutger W W Caballero-Sánchez, Noemí Gillemans, Nynke De Bleser, Pieter Nota, Benjamin De Cuyper, Iris M Salunkhe, Vishal
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Published in
Journal of leukocyte biology
Dendritic cells (DCs) are key immune modulators and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed transcription factor in DCs and coordinates relevant aspects of DC biology. Due to their role as im...
Bucşan, Allison N Williamson, Kim C
Published in
Virulence
Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have bee...
Feng, Haibo Yang, Xiaonong Fan, Jing Zhang, Linzi Liu, Qianqian Chai, Dongkun
Published in
Drug delivery
DEC-205 receptor-mediated dendritic cells (DC) targeting nanoliposomes is a promising delivery system in eliciting an immune response against pathogens. When this delivery system carries both antigen and immunomodulator, it can effectively regulate the DC function as well as the initial T cell response. To maximize the desired therapeutic effects o...
Lutckii, Anton Strunz, Benedikt Zhirkov, Anton Filipovich, Olga Rukoiatkina, Elena Gusev, Denis Lobzin, Yuriy Fischler, Björn Aleman, Soo Sällberg, Matti
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Published in
Gut
Vertical transmission of hepatitis C virus (HCV) is rare compared with other chronic viral infections, despite that newborns have an immature, and possibly more susceptible, immune system. It further remains unclear to what extent prenatal and perinatal exposure to HCV affects immune system development in neonates. To address this, we studied B cel...
Papadas, Athanasios Arauz, Garrett Cicala, Alexander Wiesner, Joshua Asimakopoulos, Fotis
Published in
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis. Multiple lines of evidence implicate versican and its bioactive proteolytic...
