Liu, Huan Jakubzick, Claudia Osterburg, Andrew R Nelson, Rebecca L Gupta, Nishant McCormack, Francis X Borchers, Michael T
Published in
American journal of respiratory cell and molecular biology
Dendritic cells (DCs) are highly specialized immune cells that capture antigens and then migrate to lymphoid tissue and present antigen to T cells. This critical function of DCs is well defined, and recent studies further demonstrate that DCs are also key regulators of several innate immune responses. Studies focused on the roles of DCs in the path...
Pezoldt, Joern Pisano, Fabio Heine, Wiebke Pasztoi, Maria Rosenheinrich, Maik Nuss, Aaron M Pils, Marina C Prinz, Immo Förster, Reinhold Huehn, Jochen
...
Published in
The Journal of infectious diseases
To successfully limit pathogen dissemination, an immunological link between the entry tissue of the pathogen and the underlying secondary lymphoid organs (SLOs) needs to be established to prime adaptive immune responses. Here, the prerequisite of CCR7 to mount host immune responses within SLOs during gastrointestinal Yersinia pseudotuberculosis inf...
Thwe, Phyu M Pelgrom, Leonard R Cooper, Rachel Beauchamp, Saritha Reisz, Julie A D'Alessandro, Angelo Everts, Bart Amiel, Eyal
Published in
Cell metabolism
Dendritic cell (DC) activation by Toll-like receptor (TLR) agonists causes rapid glycolytic reprogramming that is required to meet the metabolic demands of their immune activation. Recent efforts in the field have identified an important role for extracellular glucose sourcing to support DC activation. However, the contributions of intracellular gl...
Flórez-Grau, Georgina Cabezón, Raquel Borgman, Kyra J E España, Carolina Lozano, Juan Jose Garcia-Parajo, Maria F Benítez-Ribas, Daniel
Published in
Journal of leukocyte biology
Dendritic cells (DCs) are APCs essential in regulating the immune response. PGE2, produced during inflammation, has a pivotal role in the maturation of DCs and, therefore, is vital for the immune response. The large variety of biologic functions governed by PGE2 is mediated by its signaling through 4 distinct E-type prostanoid (EP) receptors. Immun...
Chakraborty, Kaustav Chatterjee, Soumya Bhattacharyya, Arindam
Published in
Cell biology international
Idiopathic pulmonary fibrosis (IPF) is a deadly, progressive lung disease with very few treatment options till now. Bleomycin-induced pulmonary fibrosis (BIPF) is a commonly used mice model in IPF research. TGF-β1 has been shown to play a key role in pulmonary fibrosis (PF). Dendritic cell (DC) acts as a bridge between innate and adaptive immune sy...
Sutti, Salvatore Heymann, Felix Bruzzì, Stefania Peusquens, Julia Trautwein, Christian Albano, Emanuele Tacke, Frank
Published in
Clinical science (London, England : 1979)
The chemokine fractalkine (CX3CL1) and its receptor CX3CR1 are known to mediate leukocyte chemotaxis, adhesion and survival. In the liver, CX3CR1 is expressed on multiple cell types including monocytes and dendritic cells. However, the function of CX3CR1 on hepatic dendritic cells (HDCs) is still poorly understood. In this study, we investigated th...
Simon, Sylvain Charpentier, Maud Anegon, Ignacio Labarrière, Nathalie
This 22nd edition of the Nantes Actualités Transplantation annual meeting was co-organized for the second time with the LabEx Immuno-Graft Oncology network. This international meeting was held on 1 and 2 June 2017 in Nantes (western France). The topic of this 2-day meeting was 'Immunotherapies in transplantation and cancer'. This meeting brought to...
Zhang, Jianzhi Zheng, Xin Zhao, Fengchao Liu, Xiaoyun Pang, Yong Cheng, Qi Wang, Yi Zhu, Yi Zhang, Yan
Published in
International Journal of Clinical and Experimental Pathology
Dendritic cells (DCs) were shown to enhance UHMWPE particle promoted osteoclastogenesis in RAW264.7 macrophages. This study aimed to elucidate the signaling network mediating the osteoclastogenic effects of UHMWPE particles and DCs. RAW264.7 cells were induced with UHMWPE particles and /or DC2.4 cells. The expression of Rank was silenced by shRNA. ...
Kumar, Chaitanya Kohli, Sakshi Chiliveru, Srikanth Bapsy, Poonamalle Parthasarathy Jain, Minish Suresh Attili, Venkata Sathya Mohan, Jagan Vaid, Ashok K Sharan, Bandana
Published in
Immunotherapy
A retrospective survival benefit analysis of APCEDEN®, APAC BIOTECH Pvt Ltd 69, Jacranda Marg, DLF PHASE II, Gurugram, Haryana, India, an autologous dendritic cell-based product for management of refractory solid malignancies, was performed in comparison with a control group. Subjects (retrospective data) whose survival data, geographical region, a...
Zhang, Tao Tian, Fuying Huo, Ran Tang, Aifa Zeng, Yong Duan, Yong-Gang
Published in
American journal of reproductive immunology (New York, N.Y. : 1989)
The presence of dendritic cells (DCs) and associated cytokines in follicular fluid (FF) from patients with polycystic ovary syndrome (PCOS) remains unknown. FF was collected from PCOS patients and patients with severe male factor infertility (control) at the day of transvaginal oocyte retrieval. Phenotypes of DC were detected by flow cytometry, and...