Lange, H. Müller, Thomas F. Ebel, Horst Kuhlmann, U. Grebe, Scott O. Heymanns, Jochen Feiber, Horst Riedmiller, Hubertus
Published in
Transplant International
The use of polyclonal antibodies for delayed graft function (DGF) was tested in 83 renal allograft recipients. Conventional immunosuppression (CI) was given to 52 patients with immediate graft function (IGF) while 31 patients with DGF received the polyclonal antibody ATG. Administration of OKT3 was restricted to steroid-resistant acute rejections i...
Peeters, Patrick Terryn, Wim Vanholder, Raymond Lameire, Norbert
Purpose of review: Delayed graft function is an important determinant of patient and graft survival. A complex of pathologic mechanisms intervenes in the pathophysiology of this outcome. This paper reviews the main processes involved in delayed graft function as they relate to five chronologically related stages: donor tissue quality, brain death a...
Parikh, Chirag R. Jani, Alkesh Melnikov, Vyacheslav Y. Faubel, Sarah Edelstein, Charles L.
Published in
American Journal of Kidney Diseases
Background: Interleukin-18 (IL-18) is a mediator of ischemic acute tubular necrosis (ATN) in mice. Methods: IL-18 was measured in human urine to determine whether it might serve as a marker of ATN. Seventy-two patients, including healthy controls, patients with different forms of acute renal failure, and patients with other renal diseases, were stu...
Sommerer, C. Schmidt, J. Zeier, M.
Published in
Intensivmedizin + Notfallmedizin
Das akute Nierenversagen ist ein bekanntes häufig auftretendes Problem in der postoperativen Phase nach Nierentransplantation und kann das Transplantatüberleben beeinflussen. Ursachen eines postoperativen akuten Nierenversagens nach Transplantation sind neben chirurgischen Komplikationen die akute Tubulusnekrose, akute Rejektion und Nephrotoxizität...
Yarlagadda, Sri G Coca, Steven G Garg, Amit X Doshi, Mona Poggio, Emilio Marcus, Richard J Parikh, Chirag R
Published in
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
The utilization of heterogeneous clinical criteria to define DGF has certain limitations. It will lead to delayed and sometimes inaccurate diagnosis of DGF. Hence a diagnostic test that identifies DGF reliably and early is necessary. Heterogeneity, in the definitions used for DGF, hinders the evolution of a diagnostic technique to identify DGF, whi...
Salahudeen, Abdulla K. May, Warren
Published in
Transplantation proceedings
A reduction in cold ischemia time (CIT) can be associated with better renal allograft outcomes. However few published surveys of CIT of deceased donor kidneys transplanted in the U.S. are available. We therefore surveyed the CIT using the United Network for Organ Sharing data of the last decade. A reduction in CIT was observed during the 10-yr peri...
Buchanan, P M Lentine, K L Burroughs, T E Schnitzler, M A Salvalaggio, P R
Published in
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Pulsatile machine perfusion (PMP) has been shown to reduce delayed graft function (DGF) in expanded criteria donor (ECD) kidneys. Here, we investigate whether there is a cost benefit associated with PMP utilization in ECD kidney transplants. We analyzed United States Renal Data System (USRDS) data describing Medicare-insured ECD kidney transplant r...
Krüger, Bernd Krick, Stefanie Dhillon, Navdeep Lerner, Susan M Ames, Scott Bromberg, Jonathan S Lin, Marvin Walsh, Liron Vella, John Fischereder, Michael
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft injury in human kidney transplants is unknown. Here we show that TLR4 is constitutively expressed within all donor kidneys but is significantly higher in deceased-, compa...
Tedesco-Silva, H. Lorber, M. I. Foster, C. E. Sollinger, H. W. Mendez, R. Carvalho, D. B. Shapiro, R. Rajagopalan, P. R. Mayer, H. Slade, J.
...
Web of Science
dalinkevičienė, eglė kuzminskis, vytautas petrulienė, kristina skarupskienė, inga bagdonavičiūtė, gintarė bumblytė, inga
During 10 years, 163 cadaveric kidney transplantations were performed at the Hospital of Kaunas University of Medicine. The aim of this study was to analyze the first 10-year experience in kidney transplantation and to evaluate the most frequent early and late complications after transplantation, graft and patient survival, and impact of delayed gr...
