Katou, Shadi Globke, Brigitta Morgul, M. Haluk Vogel, Thomas Struecker, Benjamin Otto, Natalie Maureen Reutzel-Selke, Anja Marksteiner, Marion Brockmann, Jens G. Pascher, Andreas
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Published in
Journal of Clinical Medicine
The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine samples from brain-dead ( n = 30) an...
Grafals, Monica Thurman, Joshua M
Published in
Frontiers in immunology
The current immunosuppressive protocols used in transplant recipients have improved short-term outcomes, but long-term allograft failure remains an important clinical problem. Greater understanding of the immunologic mechanisms that cause allograft failure are needed, as well as new treatment strategies for protecting transplanted organs. The compl...
Nieuwenhuijs-Moeke, Gertrude J Huijink, Tobias M Pol, Robert A El Moumni, Mostafa Burgerhof, Johannes GM Struys, Michel MRF Berger, Stefan P
Published in
Journal of Clinical Medicine
Background: In 2016 we observed a marked increase in functional delayed graft function (fDGF) in our living donor kidney transplantation (LDKT) recipients from 8.5% in 2014 and 8.8% in 2015 to 23.0% in 2016. This increase coincided with the introduction of a goal-directed fluid therapy (GDFT) protocol in our kidney transplant recipients. Hereupon, ...
Anutrakulchai, Sirirat Pongskul, Cholatip Kritmetapak, Kittrawee Limwattananon, Chulaporn Vannaprasaht, Suda
Published in
British journal of clinical pharmacology
Although cytochromeP450(CYP)3A5 gene polymorphism affects personalized tacrolimus doses, there is no consensus as to whether CYP3A5 genotypes should be determined to adjust the doses. The aims were to compare the therapeutic ranges and clinical outcomes between the conventional and genotype-guided tacrolimus doses. This randomized controlled study ...
Kaufmann, Kai B Baar, Wolfgang Silbach, Kai Knörlein, Julian Jänigen, Bernd Kalbhenn, Johannes Heinrich, Sebastian Pisarski, Przemyslaw Buerkle, Hartmut Göbel, Ulrich
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Published in
Progress in transplantation (Aliso Viejo, Calif.)
Delayed graft function is a major complication after kidney transplantation affecting patients' long-term outcome. The aim of this study was to identify modifiable risk factors for delayed graft function after deceased donor kidney transplantation. This is a single-center retrospective cohort study of a university transplantation center. Univariate...
Basu, Amit Rosen, Lisa M Tan, Henkie P Fishbein, Joanna Wu, Christine M Donaldson, Joseph B Stuart, Susan Shah, Nirav A McCauley, Jerry Humar, Abhinav
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Published in
Cureus
Aim We compared the outcomes of transplanting expanded criteria donor (ECD) kidneys undergoing machine perfusion (MP) versus cold storage (CS). Material and methods Data on all expanded criteria deceased donor kidney transplants performed at the University of Pittsburgh Medical Center from January 2003 through December 2012 were collected from an i...
Shamali, Awad Kassimatis, Theodoros Phillips, Benedict L Burton, Hannah Kessaris, Nicos Callaghan, Chris
Published in
Transplant international : official journal of the European Society for Organ Transplantation
The impact of the duration of delayed graft function (DGF) on graft survival is poorly characterized in controlled donation after circulatory death (DCD) donor kidney transplantation. A retrospective analysis was performed on 225 DCD donor kidney transplants between 2011 and 2016. When patients with primary nonfunction were excluded (n = 9), 141 re...
Melis, Nicolas Thuillier, Raphael Steichen, Clara Giraud, Sebastien Sauvageon, Yse Kaminski, Jacques Pelé, Thomas Badet, Lionel Richer, Jean Pierre Barrera-Chimal, Jonatan
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Published in
Expert opinion on therapeutic targets
Renal ischemia-reperfusion injury (IRI) is a significant clinical challenge faced by clinicians in a broad variety of clinical settings such as perioperative and intensive care. Renal IRI induced acute kidney injury (AKI) is a global public health concern associated with high morbidity, mortality, and health-care costs. Areas covered: This paper fo...
Melis, Nicolas Thuillier, Raphaël Steichen, Clara Giraud, Sébastien Sauvageon, Yse Kaminski, Jacques Pelé, Thomas Badet, Lionel Richer, Jean Pierre Barrera-Chimal, Jonatan
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Renal ischemia-reperfusion injury (IRI) is a significant clinical challenge faced by clinicians in a broad variety of clinical settings such as perioperative and intensive care. Renal IRI induced acute kidney injury (AKI) is a global public health concern associated with high morbidity, mortality, and health-care costs. Areas covered: This paper fo...
Pieters, Tobias T; Falke, Lucas L; Nguyen, Tri Q; Verhaar, Marianne C; Florquin, Sandrine; Bemelman, Frederike J; Kers, Jesper; Vanhove, Thomas; Kuypers, Dirk; 46355; Goldschmeding, Roel;
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Acute Tubular Injury (ATI) is the leading cause of Delayed Graft Function (DGF) after renal transplantation (RTX). Biopsies taken 1 week after RTX often show extensive tubular damage, which in most cases resolves due to the high regenerative capacity of the kidney. Not much is known about the relation between histological parameters of renal damage...
