All sea turtle populations face the risk of extinction. Of the threats to sea turtles, the effects of environmental chemicals are the least understood. Polychlorinated biphenyls (PCBs) are toxic, persistent, ubiquitous, anthropogenic halogenated organic contaminants (HOCs). While anthropogenic HOCs are notorious for their toxicity, exposure to natu...
Published in Comprehensive Toxicology
The human placenta serves several vital roles in the parturition of a developing fetus. It serves as a conduit for the transfer of both nutrients and waste products between the mother and fetus. In addition, the placenta serves as a significant source of both estrogens and progestins during the course of pregnancy. However, it is also now evident t...
Published in Comprehensive Toxicology
This chapter describes and illustrates the histologic manifestations of adaptive and degenerative hepatic responses to injurious drugs and chemicals in humans and animals. The histologic appearance of adaptive changes such as cytochrome P450 induction and peroxisome proliferation in hepatocytes is described, as well as patterns of degeneration and ...
Published in Biological Chemistry
The liver is the major organ for metabolism of drugs and other xenobiotics. Expression of many drug-metabolizing enzymes is not equally distributed throughout the liver: under normal conditions, many of them, including the most relevant members of the cytochrome P450 superfamily, are exclusively expressed in a hepatocyte subpopulation located near ...
All sea turtle populations face the risk of extinction. Of the threats to sea turtles, the effects of environmental chemicals are the least understood. Polychlorinated biphenyls (PCBs) are toxic, persistent, ubiquitous, anthropogenic halogenated organic contaminants (HOCs). While anthropogenic HOCs are notorious for their toxicity, exposure to natu...
All sea turtle populations face the risk of extinction. Of the threats to sea turtles, the effects of environmental chemicals are the least understood. Polychlorinated biphenyls (PCBs) are toxic, persistent, ubiquitous, anthropogenic halogenated organic contaminants (HOCs). While anthropogenic HOCs are notorious for their toxicity, exposure to natu...
All sea turtle populations face the risk of extinction. Of the threats to sea turtles, the effects of environmental chemicals are the least understood. Polychlorinated biphenyls (PCBs) are toxic, persistent, ubiquitous, anthropogenic halogenated organic contaminants (HOCs). While anthropogenic HOCs are notorious for their toxicity, exposure to natu...
Published in Pharmacological Reports
The aim of the present study was to investigate the possible effects of antidepressant drugs (fluvoxamine, imipramine) on the metabolism of the aliphatic-type phenothiazine neuroleptic chlorpromazine in the human liver. The experiment was performed in vitro using human liver microsomes. The kinetic analysis of chlorpromazine metabolism carried out ...
This study investigated the genotoxicity of Lapachol (LAP) evaluated by wing spot test of Drosophila melanogaster in the descendants from standard (ST) and high bioactivation (HB) crosses. This assay detects the loss of heterozygosity of marker genes expressed phenotypically on the fly's wings. Drosophila has extensive genetic homology to mammals, ...
Published in Comprehensive Toxicology
The aryl hydrocarbon receptor (AHR) is a member of the PAS (Per-Arnt-Sim) superfamily of receptors, which mediate responses to environmental stresses such as hypoxia and circadian rhythm, and control basic physiologic processes like vascular development, learning, and neurogenesis. The AHR protein is the primary mediator of the toxic effects of the...
