Leineweber, Can G. Rabehl, Miriam Pietzner, Anne Rohwer, Nadine Rothe, Michael Pech, Maciej Sangro, Bruno Sharma, Rohini Verslype, Chris Basu, Bristi
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Published in
Frontiers in Pharmacology
Hepatocellular carcinoma (HCC) is a leading cause of cancer death, and medical treatment options are limited. The multikinase inhibitor sorafenib was the first approved drug widely used for systemic therapy in advanced HCC. Sorafenib might affect polyunsaturated fatty acids (PUFA)-derived epoxygenated metabolite levels, as it is also a potent inhib...
alamo-nole, luis ponton-almodovar, adriana ortiz-laboy, ivan
In the last few years, quantum dots (QDs) have attracted research interest in different fields of science and technology. Despite their applications, it is essential to understand how nanomaterials (with different crystal sizes) are metabolized inside organisms. Thus, the focus of this study was on an evaluation of how crystal sizes of CdSTe QDs af...
djondji kamga, fleuriane metissa j. mugenzi, leon m. tchouakui, magellan sandeu, maurice marcel tatsinkou maffo, claudine grace nyegue, maximilienne ascension wondji, charles s.
Microbiome composition has been associated with insecticide resistance in malaria vectors. However, the contribution of major symbionts to the increasingly reported resistance escalation remains unclear. This study explores the possible association of a specific endosymbiont, Asaia spp., with elevated levels of pyrethroid resistance driven by cytoc...
Zhang, Yixi Yang, Baojun Yang, Zhiming Kai, Lu Liu, Zewen
Published in
Journal of agricultural and food chemistry
Cytochrome P450 enzymes metabolize various xenobiotics in insects. Compared to numerous P450s associated with insecticide detoxification and resistance, fewer have been identified to bioactivate proinsecticides in insects. Here we reported that two P450s, CYP4C62 and CYP6BD12, in Nilaparvata lugens could bioactivate chlorpyrifos, an organophosphoru...
jia, nan jiang, yuting jian, xianyi cai, tong liu, qing liu, yuan xing, dan dong, yande guo, xiaoxia zhao, tongyan
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Zika virus (ZIKV), which is mainly transmitted by Aedes albopictus in temperate zones, can causes serious neurological disorders. However, the molecular mechanisms that influence the vector competence of Ae. albopictus for ZIKV are poorly understood. In this study, the vector competence of Ae. albopictus mosquitoes from Jinghong (JH) and Guangzhou ...
werck-reichhart, danièle
Plant cytochrome P450 monooxygenases were long considered to be highly substrate-specific, regioselective and stereoselective enzymes, in this respect differing from their animal counterparts. The functional data that have recently accumulated clearly counter this initial dogma. Highly promiscuous P450 enzymes have now been reported, mainly in terp...
Lian, Dongyin Chen, Tengfei Yan, Lihua Hou, Hongping Gao, Shuangrong Hu, Qin Zhang, Guangping Li, Han Song, Ling Gao, Yunhang
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Published in
Frontiers in Pharmacology
Background: A. chinense frequently used in Miao medicine to treat rheumatic diseases. However, as a famous toxic herb, Alangium chinense and its representative components exhibit ineluctable neurotoxicity, thus creating significant challenges for clinical application. The combined application with compatible herbs in Jin-Gu-Lian formula attenuates ...
Cho, Hyunki Kim, Young Jun Chae, Jung-Woo Meyer, Markus R. Kim, Sang Kyum Ryu, Chang Seon
Published in
Frontiers in Pharmacology
The SARS-CoV-2 pandemic requires a new therapeutic target for viral infection, and papain-like protease (Plpro) has been suggested as a druggable target. This in-vitro study was conducted to examine the drug metabolism of the GRL0617 and HY-17542, Plpro inhibitors. Metabolism of these inhibitors was studied to predict the pharmacokinetics in human ...
lautier, thomas smith, derek j. yang, lay kien chen, xixian zhang, congqiang truan, gilles nic lindley, d
Molecular biodiversity results from branched metabolic pathways driven by enzymatic regioselectivities. An additional complexity occurs in metabolites with an internal structural symmetry, offering identical extremities to the enzymes. For example, in the terpene family, β-carotene presents two identical terminal closed-ring structures. Theses cycl...
rančić, aleksandra babić, nikola orio, maylis peyrot, fabienne
Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection. Since conventional tetramethyl-substituted cyclic nitroxides have insufficient in vivo stability, efforts have recently been made to synthesize more stable, tetrae...
