ABSTRACTGentamicin is frequently administered in combination with the penicillins for the treatment of suspected or proven neonatal sepsis. Empiric gentamicin dosing regimens based on the neonate's weight, gestational age, postnatal age, post-conceptional age or renal function have been designed to achieve therapeutic serum concentrations. Correlat...
ABSTRACTThe common practice of adjusting vancomycin dosage based on peak and trough serum levels is examined. To justify the routine monitoring of serum levels of any drug, it must have predictable pharmacokinetics; there must be a correlation between serum levels and effect; and the drug must have a narrow therapeutic index. Peak vancomycin levels...
Published in Thérapie
Mitotane provided serious side effects and low doses seemed to be tolerated. Determination of mitotane concentration in plasma is recommended. We report the case of toxic plasma levels with low doses of mitotane in a 47-year-old man with adrenocortical cancer.
