Yang, Feng-Jung Hou, Ying-Hui Chang, Ray-E
Published in
Journal of Medical Internet Research
Background Stage 5 chronic kidney disease (CKD) presents a high risk for dialysis initiation and for complications such as uremic encephalopathy, uremic symptoms, gastrointestinal bleeding, and infection. One of the most common barriers to health care for patients with stage 5 CKD is poor continuity of care due to unresolved communication gaps. Obj...
lee, sun lee, in-kyu jeon, jae-han
Vascular calcification (VC), which is categorized by intimal and medial calcification, depending on the site(s) involved within the vessel, is closely related to cardiovascular disease. Specifically, medial calcification is prevalent in certain medical situations, including chronic kidney disease and diabetes. The past few decades have seen extensi...
glorieux, griet gryp, tessa perna, alessandra
Several of the uremic toxins, which are difficult to remove by dialysis, originate from the gut bacterial metabolism. This opens opportunities for novel targets trying to decrease circulating levels of these toxins and their pathophysiological effects. The current review focuses on immunomodulatory effects of these toxins both at their side of orig...
Opazo-Ríos, Lucas Mas, Sebastián Marín-Royo, Gema Mezzano, Sergio Gómez-Guerrero, Carmen Moreno, Juan Antonio Egido, Jesús
Published in
International Journal of Molecular Sciences
Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumula...
Kimura, Tomomi Snijder, Robert Nozaki, Kazutoshi
Published in
Kidney International Reports
Introduction Although early intervention for chronic kidney disease (CKD) and renal anemia are desirable, these conditions are often asymptomatic during their early stages and may be underdiagnosed. Methods We retrospectively analyzed Japanese administrative claims data for general and hospital populations. The data period for the general and hospi...
Kumari, Manju Mohan, Aradhana Ecelbarger, Carolyn M. Gupta, Amit Prasad, Narayan Tiwari, Swasti
Published in
Frontiers in Physiology
Micro-RNAs (miRs) encapsulated inside urinary exosomes (uEs) have the potential as early biomarkers. Previously, we reported that a rise in uE miR-451 predicted albuminuria in diabetic rats; however, whether the rise was protective or detrimental, and occurred in response to injury or general hyperglycemia, was unknown. To address this, we studied ...
adair, kathleen e. bowden, rodney g.
Novel approaches to ameliorating chronic kidney disease (CKD) are warranted as most patients are undiagnosed until they begin displaying symptoms of kidney failure. There is increasing evidence that a whole food plant-based (WFPB) diet may offer benefits that slow the progression of CKD, decrease the incidence cardiovascular disease, decrease rates...
Abad, Kashif Kien, Cassandra Ganta, Kavitha
Published in
Cureus
Metabolic acidosis is a common disorder defined by an imbalance in the body’s acid-base balance. Identifying the cause of acidosis is critical for its management. We describe a case of acute renal failure with lactic acidosis in a 69-year-old man who was taking metformin for type 2 diabetes. The patient presented with decreased urine output after t...
Kabasawa, Keiko Tanaka, Junta Nakamura, Kazutoshi Ito, Yumi Yoshida, Kinya Takachi, Ribeka Sawada, Norie Tsugane, Shoichiro Narita, Ichiei
Published in
Journal of epidemiology
Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles. All 67,322 residents aged ≥40 years in Minamiuonuma City, Uonuma City, and Yuzawa ...
lano, guillaume burtey, stéphane sallée, marion
Chronic kidney disease (CKD) is associated with a high prevalence of cardiovascular diseases. During CKD, the uremic toxin indoxyl sulfate (IS)&mdash / derived from tryptophan metabolism&mdash / accumulates. IS is involved in the pathophysiology of cardiovascular complications. IS can be described as an endotheliotoxin: IS induces endothelial dysfu...
