Kacher, Radhia Mounier, Coline Caboche, Jocelyne Betuing, Sandrine
Published in
Frontiers in Aging Neuroscience
Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene. The associated neurodegeneration mainly affects the striatum and the cortex at early stages and progressively spreads to other brain structures. Targeting HD at its earlier stages is under intense inve...
Lin, Yanan Peng, Xiaoyan Lin, Xu Deng, Xiyuan Liu, Fanghao Tao, He Dong, Rui Wang, Bin Bi, Yanlin
Published in
Frontiers in Psychiatry
Objective We aimed to investigate the relationship between preoperative lipid level and postoperative delirium (POD) and explore whether lipid’s effect on POD is mediated by POD core protein. Methods A total of 635 patients who were planned to undergo knee/hip arthroplasty under combined spinal-epidural anesthesia, regardless of gender, were select...
Park, Hyunjung Park, Hyerin Baek, Jiyeon Moon, Hyuk Ro, Simon Weonsang
Published in
Biology
Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. To date, receptor tyrosine kinases (RTKs) are the most favored molecular targets for the treatment of HCC, followed by immune checkpoint regulators such as PD-1, PD-L1, and CTLA-4. With less than desirable clinical outcomes from RTK inhibit...
Lee, Kounseok Kim, Sunhae Jo, Jung Ki
Published in
Journal of clinical medicine
(1) Background: Serum lipid levels affect not only nutritional status but also emotional state. The purpose of this study was to examine the effects of various socio-demographic characteristics, abnormal cholesterol levels, and BMI indicators on depressive symptoms and suicidal ideation in the Korean population. (2) Methods: A total of 23,692 peopl...
Jia, Meiyu Sun, Mingxia Tang, Yan-Dong Zhang, Yu-Yuan Wang, Haiwei Cai, Xuehui Meng, Fandan
Published in
Frontiers in Veterinary Science
Senecavirus A (SVA), an important member of the Picornaviridae family, causes vesicular disease in pigs. Here, we generated an EGFP-expressing recombinant SVA re-SVA-EGFP, which exhibited similar growth kinetics to its parental virus. The reporter SVA was used to study the role of pig ANTXR1 (pANTXR1) in SVA infection in a porcine alveolar macropha...
Jutrić, David Đikić, Domagoj Boroš, Almoš Odeh, Dyna Drozdek, Sandra Domjanić Gračan, Romana Dragičević, Petar Crnić, Irena Jurčević, Irena Landeka
Published in
Archives of Industrial Hygiene and Toxicology
Valproate is a common antiepileptic drug whose adverse effects include liver steatosis and dyslipidaemia. The aim of our study was to see how natural flavonoid antioxidant naringin would interact with valproate and attenuate these adverse effects. For this reason we treated male C57BL6 mice with a combination of 150 mg/kg of valproate and 25 mg/kg ...
Tripathi, Rekha Aggarwal, Tanya Lindberg, Frida A. Klemm, Anna H. Fredriksson, Robert
Published in
Frontiers in Cell and Developmental Biology
Glutamate acts as a critical regulator of neurotransmitter balance, recycling, synaptic function and homeostasis in the brain and glutamate transporters control glutamate levels in the brain. SLC38A10 is a member of the SLC38 family and regulates protein synthesis and cellular stress responses. Here, we uncover the role of SLC38A10 as a transceptor...
Zhuang, Qian Cheng, Jinnian Xia, Jie Ning, Min Wu, Shan Shen, Shuang Shi, Yan Huang, Dan Dong, Zhixia Wan, Xinjian
...
Published in
Frontiers in Medicine
Gypenosides (GPs), obtained from Gynostemma pentaphyllum (Thunb.) Makino, have been traditionally prescribed to treat metabolic disorders in Asians. This study assessed whether GPs could prevent lithogenic diet (LD)-induced cholesterol gallstone (CG) formation and enhance CG dissolution in mice. Gallstone-susceptible C57BL/6J mice were fed an LD or...
Tarbeeva, Darya V Pislyagin, Evgeny A Menchinskaya, Ekaterina S Berdyshev, Dmitrii V Kalinovskiy, Anatoliy I Grigorchuk, Valeria P Mishchenko, Natalia P Aminin, Dmitry L Fedoreyev, Sergey A
Published in
Antioxidants (Basel, Switzerland)
Pterocarpans and related polyphenolics are known as promising neuroprotective agents. We used models of rotenone-, paraquat-, and 6-hydroxydopamine-induced neurotoxicity to study the neuroprotective activity of polyphenolic compounds from Lespedeza bicolor and their effects on mitochondrial membrane potential. We isolated 11 polyphenolic compounds:...
Record, Michel Attia, Mehdi Carayon, Kevin Pucheu, Laly Bunay, Julio Soulès, Régis Ayadi, Silia Payré, Bruno Perrin‐Cocon, Laure Bourgailh, Florence
...
Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes. Dendrogenin A (DDA) is an endogenous tumour suppressor cholesterol-derived metabolite. It is a new class of ligand of the nuclear Liver X receptors (LXR) which ...