Bonds, Amber C Yuan, Tianao Werman, Joshua M Jang, Jungwon Lu, Rui Nesbitt, Natasha M Garcia-Diaz, Miguel Sampson, Nicole S
Published in
ACS infectious diseases
Cholesterol is a major carbon source for Mycobacterium tuberculosis (Mtb) during infection, and cholesterol utilization plays a significant role in persistence and virulence within host macrophages. Elucidating the mechanism by which cholesterol is degraded may permit the identification of new therapeutic targets. Here, we characterized EchA19 (Rv3...
Bleve, Augusto Durante, Barbara Sica, Antonio Consonni, Francesca Maria
Published in
International Journal of Molecular Sciences
Cancer progression generates a chronic inflammatory state that dramatically influences hematopoiesis, originating different subsets of immune cells that can exert pro- or anti-tumor roles. Commitment towards one of these opposing phenotypes is driven by inflammatory and metabolic stimuli derived from the tumor-microenvironment (TME). Current immuno...
Low, Hann Mukhamedova, Nigora Capettini, Luciano Dos Santos Aggum Xia, Yining Carmichael, Irena Cody, Stephen H Huynh, Kevin Ditiatkovski, Michael Ohkawa, Ryunosuke Bukrinsky, Michael
...
Published in
Arteriosclerosis, thrombosis, and vascular biology
AIBP (apolipoprotein A-I binding protein) is an effective and selective regulator of lipid rafts modulating many metabolic pathways originating from the rafts, including inflammation. The mechanism of action was suggested to involve stimulation by AIBP of cholesterol efflux, depleting rafts of cholesterol, which is essential for lipid raft integrit...
Lim, Jihyeon Aguilan, Jennifer T. Sellers, Rani S. Nagajyothi, Fnu Weiss, Louis M. Angeletti, Ruth Hogue Bortnick, Anna E.
Published in
Journal of molecular histology
Severe aortic stenosis (AS) is prevalent in adults ≥65 years, a significant cause of morbidity and mortality, with no medical therapy. Lipid and proteomic alterations of human AS tissue were determined using mass spectrometry imaging (MSI) and liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to understand histop...
Carlin, Cathleen Manor, Danny
Published in
International Journal of Molecular Sciences
In addition to providing invaluable insights to the host response to viral infection, adenovirus continues to be an important model system for discovering basic aspects of cell biology. This is especially true for products of early region three (E3), which have provided the foundation for understanding many new mechanisms regulating intracellular t...
Kenny, Douglas J Plichta, Damian R Shungin, Dmitry Koppel, Nitzan Hall, A Brantley Fu, Beverly Vasan, Ramachandran S Shaw, Stanley Y Vlamakis, Hera Balskus, Emily P
...
Published in
Cell host & microbe
The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification of functional enzymes and micro...
Nechipurenko, Inna V.
Published in
Frontiers in Cell and Developmental Biology
Primary cilia are specialized cellular structures that project from the surface of most cell types in metazoans and mediate transduction of major signaling pathways. The ciliary membrane is contiguous with the plasma membrane, yet it exhibits distinct protein and lipid composition, which is essential for ciliary function. Diffusion barriers at the ...
Korolkova, Olga Y. Widatalla, Sarrah E. Williams, Stephen D. Whalen, Diva S. Beasley, Heather K. Ochieng, Josiah Grewal, Thomas Sakwe, Amos M.
Published in
Cells
The calcium (Ca2+)-dependent membrane-binding Annexin A6 (AnxA6), is a multifunctional, predominantly intracellular scaffolding protein, now known to play relevant roles in different cancer types through diverse, often cell-type-specific mechanisms. AnxA6 is differentially expressed in various stages/subtypes of several cancers, and its expression ...
Hong, Chang-Sook Jeong, Emily Boyiadzis, Michael Whiteside, Theresa L.
Published in
Journal of Extracellular Vesicles
Most patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs) are known to play a significant role in leukaemia drug resistance by delivery of anti-apoptotic proteins and genes conferring resistance to recipient cells. sEV leve...
Yan, Ruicheng Luo, Jianfei He, Xiaobo Li, Shijun
Published in
The Journal of International Medical Research
Objective To investigate the association between three single nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) gene family and susceptibility to type 2 diabetes mellitus in a Chinese Han population. Methods A total of 1086 type 2 diabetes patients and 1122 healthy controls were included in this retrospective study. Three genetic va...
