D’Agostino, Gianluca Artinger, Marc Locati, Massimo Perez, Laurent Legler, Daniel F. Bianchi, Marco E. Rüegg, Curzio Thelen, Marcus Marchese, Adriano Rocchi, Marco B. L.
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Published in
Frontiers in Immunology
The chemokine receptor CXCR4 plays a fundamental role in homeostasis and pathology by orchestrating recruitment and positioning of immune cells, under the guidance of a CXCL12 gradient. The ability of chemokines to form heterocomplexes, enhancing their function, represents an additional level of regulation on their cognate receptors. In particular,...
Dhilip Kumar, Sathish Sundar Houreld, Nicolette Nadene Abrahamse, Heidi
Published in
International Journal of Nanomedicine
Introduction Silver nanoparticles (AgNPs) have been extensively used in wound healing applications owing to their valuable physicochemical and biological properties. The main objective of this study was to evaluate the combined effects of green-synthesized silver nanoparticles (G-AgNPs) and photobiomodulation (PBM; laser irradiation at 830 nm with ...
AlQathama, Aljawharah Ezuruike, Udoamaka F. Mazzari, Andre L. D. A. Yonbawi, Ahmed Chieli, Elisabetta Prieto, Jose M.
Published in
Frontiers in Pharmacology
Medicinal plants indicated for chronic diseases usually have good safety margins as they are intended for lifelong treatments. We hypothesized that they may provide patients with baseline protection to cancers and multidrug resistance-reversing phytochemicals resulting in successful prevention and/or adjuvant treatment of chemotherapy-resistant can...
Bongaerts, Maud Aizel, Koceila Secret, Emilie Jan, Audric Nahar, Tasmin Raudzus, Fabian Neumann, Sebastian Telling, Neil Heumann, Rolf Siaugue, Jean-Michel
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Published in
International Journal of Molecular Sciences
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles appears to be promising, since magnetic fields can act at a distance without interactions with the surr...
Clauder, Franziska Möller, Stephanie Köhling, Sebastian Bellmann-Sickert, Kathrin Rademann, Jörg Schnabelrauch, Matthias Beck-Sickinger, Annette G
Published in
Journal of tissue engineering and regenerative medicine
Supporting the wound healing process by sending the appropriate cytokine signals can shorten healing time and overcome chronic inflammation syndromes. Even though adhesion peptides consisting of Arg-Gly-Asp (RGD) are commonly used to enhance cell-surface interactions, peptide-mediated cytokine delivery has not been widely exploited so far. Cytokine...
Qiongna, Dong Jiafeng, Zhang Yalin, Hao Ping, He Chuan, Zhou Xiaojie, Jin Miaomiao, Zhao Yiting, Shao Hui, Zhao
Published in
Journal of clinical laboratory analysis
Given the reliability of circRNAs in symbolizing cancer progression, this investigation was designed to expound the involvement of hsa_circ_0028007 in regulating chemosensitivity of nasopharyngeal carcinoma (NPC) cells. Altogether, 241 pairs of NPC tissues and para-cancerous normal tissues were collected to identify NPC-symbolic circRNAs, which hav...
He, Li-Hong He, Yong-Lin Zuo, Wen-Hang Kang, Yue Xue, Huan Wang, Ling-Yun Zhang, Yun-Liang Meng, Yong
Published in
Journal of clinical laboratory analysis
Neuropilin1 (NRP1) participates in cancer cell proliferation, migration, and metastasis as a multifunctional co-receptor by interacting with multiple signal pathways, but few studies have addressed the precise function of NRP1 in pancreatic cancer (PACA) cells. We aimed to study whether NRP1 gene silencing involved in the proliferation and migratio...
Ouyang, Xi-Lin Yang, Li Huang, Lei Pan, Ying-Ming
Published in
Natural product research
In this study, antitumor activity and composition analysis of the core of Camellia osmantha fruit were investigated. The cores were extracted by 80% ethanol to obtain the crude extract (TF), which was successively distributed by different concentrations of ethanol with MCI resin to obtain three different parts (Frs 1 to 3). Cytotoxicity activities ...
Wang, Chengdong Qi, Xufeng Zhou, Xiang Sun, Jianmin Cai, Dongqing Lu, Gang Chen, Xiongfong Jiang, Zhihua Yao, Yong-Gang Chan, Wai Yee
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The proto-oncogene ets1 is highly expressed in the pre-migratory and migratory neural crest (NC), and has been implicated in the delamination and migration of the NC cells. To identify the downstream target genes of Ets1 in this process, we did RNA sequencing (RNA-Seq) on wild-type and ets1 mutant X. tropicalis embryos. A list of genes with signifi...
Miyano, Kei Okamoto, Shuichiro Yamauchi, Akira Kajikawa, Mizuho Kiyohara, Takuya Taura, Masahiko Kawai, Chikage Kuribayashi, Futoshi
Published in
Free radical research
Superoxide producing NADPH oxidase 1 (Nox1), abundantly expressed in the colon epithelium, plays a crucial role in mucosal host defenses. In this study, we found that pre-treatment of cells with edaravone, a free radical scavenger, inhibited Nox1 constitutive activity even after washout without affecting Nox1 trafficking to the plasma membrane and ...
