Huang, He Zhang, Jun Ling, Fei Huang, Yuhong Yang, Min Zhang, Yao Wei, Yuanyi Zhang, Qingqing Wang, Honghai Song, Lin
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Published in
Cancer Cell International
BackgroundLeptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. However, the role of LEPR and its underlying mechanisms in lymphatic metastasis of hepatocarcinoma have not yet been studied.MethodsWe performed bioinformatics analysis, qRT-PCR, western blotting, immunohistochemistry, immunofluorescence, enzyme-linked i...
Alsharif, Sarah Sharma, Pooja Bursch, Karina Milliken, Rachel Lam, Van Fallatah, Arwa Phan, Thuc Collins, Meagan Dohlman, Priya Tiufekchiev, Sarah
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Published in
Cell Adhesion & Migration
A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated, we found that K19 is required to maintain rounded epithelial-like shape and tight cell-cell adhesion. A loss of K19 also lowered cell surface E-cadherin levels. Inhi...
de Curtis, Ivan
Published in
Trends in cell biology
Liquid-liquid phase separation drives the formation of biomolecular condensates (BCs) for the spatiotemporal organization of several cellular processes. Recent evidences indicate that components of plasma-membrane-associated platforms form biomolecular condensates near focal adhesions (FAs), and suggest that phase separation regulates dynamic proce...
Muñoz-Hidalgo, Lisandra San-Miguel, Teresa Megías, Javier Serna, Eva Calabuig-Fariñas, Silvia Monleón, Daniel Gil-Benso, Rosario Cerdá-Nicolás, Miguel López-Ginés, Concha
Published in
International Journal of Molecular Sciences
Migration of glioblastoma cells into surrounding tissue is one of the main features that makes this tumor incurable. We evaluated whole-genome miRNA expression profiling associated with different EGFR amplification patterns in 30 cases of primary glioblastoma. From the 64 miRNAs that showed differential expression between tumors with a high level o...
Singh, Shashi Prakash Insall, Robert H.
Published in
Communicative & Integrative Biology
The Scar/WAVE complex catalyzes the protrusion of pseudopods and lamellipods, and is therefore a principal regulator of cell migration. However, it is unclear how its activity is regulated, beyond a dependence on Rac. Phosphorylation of the proline-rich region, by kinases such as Erk2, has been suggested as an upstream activator. We have recently r...
Chuang, Pei-Chin Lu, Chun-Wun Tsai, Ching-Chin Tseng, Shun-Hung Su, Wen-Hong
Published in
International Journal of Molecular Sciences
Despite the distant metastasis of cervical cancer cells being a prominent cause of mortality, neither the metastasis capacity nor the in vitro conditions mimicking adhesion of cervical cancer cells to endothelial cells have been fully elucidated. Circulating metastatic cancer cells undergo transendothelial migration and invade normal organs in dist...
Bytautaite, Meda Petrikaite, Vilma
Published in
OncoTargets and therapy
Introduction Statins are a type of drugs that are used to lower cholesterol level in blood. Since the early 1990s, it has been known that statins could be beneficial in cancer therapy. However, data remain controversial, especially regarding estrogen receptors status. Despite many studies in breast cancer models in vitro, the correlations of effect...
Do, Ha Thi Thu Cho, Jungsook
Published in
International Journal of Molecular Sciences
Chemokine–receptor interactions play multiple roles in cancer progression. It was reported that the overexpression of X-C motif chemokine receptor 1 (XCR1), a specific receptor for chemokine X-C motif chemokine ligand 1 (XCL1), stimulates the migration of MDA-MB-231 triple-negative breast cancer cells. However, the exact mechanisms of this process ...
Yahya, Imadeldin Morosan-Puopolo, Gabriela Brand-Saberi, Beate
Published in
Frontiers in Cell and Developmental Biology
Trunk and head muscles originate from distinct embryonic regions: while the trunk muscles derive from the paraxial mesoderm that becomes segmented into somites, the majority of head muscles develops from the unsegmented cranial paraxial mesoderm. Differences in the molecular control of trunk versus head and neck muscles have been discovered about 2...
Juanes, M. Angeles
Published in
Cancers
Simple Summary Colorectal cancer is the third leading cause of cancer death globally. As well as the adverse health implications for the individual, there are also considerable economic and social impacts associated with workplace absence and healthcare expenses. It is critical to understand the events that govern gut homeostasis to improve cancer ...
