HMGB1 (High-Mobility Group Box-1): A Common Link Determining the Consequences of Tissue Injury, Sterile/Microbial and Lo...
Published in Arteriosclerosis, thrombosis, and vascular biology
COVID-19 and Parkinson’s Disease: Shared Inflammatory Pathways Under Oxidative Stress †
Published in Brain Sciences
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson’s disease (PD). Increasing evidence suggests an involvement of oxidative stress and contribution of NFκB in ...
Cadherin-11 Is Required for Neural Crest Specification and Survival
Published in Frontiers in Physiology
Neural crest (NC) cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the peripheral nervous system in vertebrates. NC cells express many cadherin proteins, which control their specification, epithelial to mesenchymal transition (EMT), migration, and mesenchymal to epithelial transition. Abnormal NC dev...
TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis
Published in Oncology Letters
Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function of TIPE1 in ovarian cancer. TIPE1 expression was determined in tissue microarrays and ovarian cancer cells, and these dat...
Pyroptosis Plays a Role in Osteoarthritis
Published in Aging and Disease
Recent studies have revealed novel forms of cell death beyond the canonical types of cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme microenvironmental factors. Pyroptosis, a type of regulated cell death, occurs when pattern recognition receptors (PRRs) induce the activation of cysteine-aspartic protease ...
FLIP(L): the pseudo-caspase.
Published in The FEBS journal
Possessing structural homology with their active enzyme counterparts but lacking catalytic activity, pseudoenzymes have been identified for all major enzyme groups. Caspases are a family of cysteine-dependent aspartate-directed proteases that play essential roles in regulating cell death and inflammation. Here, we discuss the only human pseudo-casp...
Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry
Published in Molecules
Peptidyl fluoromethyl ketones occupy a pivotal role in the current scenario of synthetic chemistry, thanks to their numerous applications as inhibitors of hydrolytic enzymes. The insertion of one or more fluorine atoms adjacent to a C -terminal ketone moiety greatly modifies the physicochemical properties of the overall substrate, especially by inc...
Role of inflammasomes in innate host defense against Entamoeba histolytica.
Published in Journal of leukocyte biology
Intestinal amebiasis is the disease caused by the extracellular protozoan parasite Entamoeba histolytica (Eh) that induces a dynamic and heterogeneous interaction profile with the host immune system during disease pathogenesis. In 90% of asymptomatic infection, Eh resides with indigenous microbiota in the outer mucus layer of the colon without prom...
Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities
Published in Plants
Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A high performance liquid chromatography diode array revealed several polyphenols in the leaf extracts for the first time, including p -coumaric acid, rosmarinic acid, chlorogenic acid, ferulic acid...
Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial P...
Published in Pathogens
The intestinal protozoan parasite, Giardia duodenalis , infects a large number of people in the world annually. Giardia infection has been considered a negative effect on intestinal epithelial cell growth, while the underlying mechanisms remain to be explored. Here we evaluated reactive oxygen species (ROS) production and apoptotic events in Giardi...
