Jiang, Conglin Zou, Xiang Zhu, Renqing Shi, Yimin Wu, Zehan Zhao, Fan Chen, Liang
Published in
Journal of neurosurgery
Intraventricular hemorrhage (IVH) is found in approximately 40% of intracerebral hemorrhages and is associated with increased mortality and poor functional outcome. Cognitive impairment is one of the complications and occurs due to various pathological changes. Amyloid beta (Aβ) accumulation and neuroinflammation, and the Alzheimer disease-like pat...
Shvedova, M. V. Anfinogenova, Ya. D. Shchepetkin, I. A. Atochin, D. N.
Published in
Neuroscience and Behavioral Physiology
We present here a review of the literature on the role of c-Jun N-terminal kinases (JNK) and their inhibitors in ischemic and reperfusion brain injuries. The functions of JNK in the signal mechanisms involved in brain damage in ischemia and reperfusion are discussed. Effects linked with inhibition of JNK with synthetic and natural compounds in expe...
Bai, Bing-Li Xie, Zhong-Jie Weng, She-Ji Wu, Zong-Yi Li, Hang Tao, Zhou-Shan Boodhun, Viraj Yan, De-Yi Shen, Zi-Jian Tang, Jia-Hao
...
Published in
Journal of biomaterials science. Polymer edition
Chitosan Oligosaccharide (COS) has been widely used for the systemic treatment of clinical diseases such as bone tissue engineering. However, its influence on osteoclast formation, which plays a critical role in bone homeostasis, has never been investigated. The aim of this study was to investigate the effect of chitosan oligosaccharide on differen...
Xiao, G Yang, R Dang, L Dong, C L
Published in
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
目的： 研究和厚朴酚（HNK）强化肿瘤坏死因子相关凋亡诱导配体（TRAIL）抗肝细胞癌HepG2细胞的作用及其机制。 方法： 常规培养HepG2细胞，首先给予梯度浓度HNK处理，观察其对肿瘤细胞活力的影响；Western blot法检测c-Jun氨基末端激酶（JNK）、死亡受体4（DR4）、DR5表达水平变化。进而联合应用HNK与TRAIL，观察联合用药对肿瘤细胞活力的影响；检测凋亡相关蛋白表达水平明确凋亡情况。然后采用JNK抑制剂SP600125阻断JNK通路，明确DR4、DR5水平变化是否由JNK信号通路介导。最后构建裸鼠皮下肿瘤模型，明确在体内水平下，HNK对TRAIL的强化效果。 结果： 梯度浓度HNK处理细胞后细胞活力剂量依赖性降低（P
Umbayev, Bauyrzhan Masoud, Abdul-Razak Tsoy, Andrey Alimbetov, Dauren Olzhayev, Farkhad Shramko, Alla Kaiyrlykyzy, Aiym Safarova, Yuliya Davis, Terence Askarova, Sholpan
...
Published in
Biogerontology
Mesenchymal stem cells (MSCs) represent a promising cell source for cellular therapy and tissue engineering and are currently being tested in a number of clinical trials for various diseases. However, like other somatic cells, MSCs age, and this senescence is accompanied by a progressive decline in stem cell function. Several lines of evidence sugg...
de Lemos, Luisa Junyent, Felix Camins, Antoni Castro-Torres, Rubén Darío Folch, Jaume Olloquequi, Jordi Beas-Zarate, Carlos Verdaguer, Ester Auladell, Carme
Published in
Molecular Neurobiology
The activation of c-Jun-N-terminal kinases (JNK) pathway has been largely associated with the pathogenesis and the neuronal death that occur in neurodegenerative diseases. Altogether, this justifies why JNKs have become a focus of screens for new therapeutic strategies. The aim of the present study was to identify the role of the different JNK isof...
Gao, Xianlong Wu, Xiaomin Yan, Jiajie Zhang, Jingqun Zhao, Weiwei DeMarco, Dominic Zhang, Yongguo Bakhos, Mamdouh Mignery, Gregory Sun, Jun
...
Published in
Cardiovascular research
c-jun N-terminal kinase (JNK) is a critical stress response kinase that activates in a wide range of physiological and pathological cellular processes. We recently discovered a pivotal role of JNK in the development of atrial arrhythmias in the aged heart, while cardiac CaMKIIδ, another pro-arrhythmic molecule, was also known to enhance atrial arrh...
Lv, Hongyang Yang, Jing Wang, Chenglin Yu, Fanyuan Huang, Dingming Ye, Ling
Published in
Archives of oral biology
The aim of this study is to investigate the role of the WNT7B protein in the migration and differentiation of human dental pulp cells (HDPCs). The effect of recombinant human WNT7B (rhWNT7B) on the proliferation and migration of HDPCs was evaluated by 5-ethynyl-2'-deoxyuridine (EdU), immunofluorescence staining of Ki67, flow cytometry and scratch a...
Liu, Haojie Zhou, Ming
Published in
BMC Complementary and Alternative Medicine
BackgroundQuercetin (QCT) is a flavonol present in many vegetables, it is proved to show chemo preventive effect against lung, cervical, prostate, breast and colon cancer due to its anti-inflammatory, anti-tumor and anti-oxidant property. Looking into the reported chemo-preventive effect we speculated antitumor activity in retinoblastoma (RB) Y79 c...
Ma, Chunyu Yu, Hongyu Xiao, Ying Wang, Huijiao
Published in
Pharmaceutical biology
Momordica charantia L. (Cucurbitaceae) has long been widely used as a traditional remedy for diabetes mellitus in some countries. However, detailed antidiabetic mechanisms are largely unknown. This study clarified the ameliorating effects of M. charantia ethanol extracts (MCE) on the insulin resistance in type 2 diabetes mellitus (T2DM) rats. T2DM ...
