Sun, Yonghao Zhang, Dejuan Mao, Mao Lu, Yangping Jiao, Ning
Published in
Experimental and therapeutic medicine
The aim of the present study was to investigate the inhibitory effect of compound cantharides capsules (CCCs) on the viability and apoptosis of human gastric cancer cell lines, BGC-823 and SGC-7901, and to detect its regulation of gene expression levels, as well as its inhibition mechanisms. Each cell line was grouped into a control group, CCC seru...
Shen, Haitao Wu, Na Wang, Yu Han, Xinfei Zheng, Qiang Cai, Xue Zhang, Honglei Zhao, Min
Published in
Inflammation
Acute lung injury (ALI) is a major complication soon after paraquat poisoning and rapidly progresses with high mortality. However, the specific mechanism underlying paraquat-induced ALI is still unclear. In this study, the mechanism underlying the protective effects of SP600125 on paraquat-induced ALI was investigated according to oxidative stress,...
Qiu, Lin Zhang, Boyao Liu, Lang Wang, Xiaoping Lei, Chaoliang Lin, Yongjun Zhao, Jing Ma, Weihua
Published in
Journal of economic entomology
The mitogen-activated protein kinases (MAPKs) are conserved signal transduction pathways and broadly responsible for bacterial infection from yeast to mammals, and virus, fungi, and bacteria, specifically Bacillus thuringiensis, to insects. But little is known about the MAPK pathways in antibacterial responses in Chilo suppressalis (Walker), an imp...
Sun, Wen Wu, Xiaxia Gao, Hongwei Yu, Jie Zhao, Wenwen Lu, Jin-Jian Wang, Jinhua Du, Guanhua Chen, Xiuping
Published in
Free radical biology & medicine
Necroptosis is a form of programmed necrosis mediated by signaling complexes with receptor-interacting protein 1 (RIP1) and RIP3 kinases as the main mediators. However, the underlying execution pathways of this phenomenon have yet to be elucidated in detail. In this study, a RIP1/RIP3 complex was formed in 2-methoxy-6-acetyl-7-methyljuglone (MAM)-t...
de Lemos, Luisa Junyent, Felix Camins, Antoni Castro-Torres, Rubén Darío Folch, Jaume Olloquequi, Jordi Beas-Zarate, Carlos Verdaguer, Ester Auladell, Carme
Published in
Molecular Neurobiology
The activation of c-Jun-N-terminal kinases (JNK) pathway has been largely associated with the pathogenesis and the neuronal death that occur in neurodegenerative diseases. Altogether, this justifies why JNKs have become a focus of screens for new therapeutic strategies. The aim of the present study was to identify the role of the different JNK isof...
Xue, Long-Xing Liu, Hong-Yu Cui, Yang Dong, Yue Wang, Jiao-Qi Ji, Qiu-Ye He, Jin-Ting Yao, Min Wang, Ying-Ying Shao, Yan-Kun
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Published in
Neural regeneration research
Activin A, a member of the transforming growth factor-beta superfamily, plays a neuroprotective role in multiple neurological diseases. Endoplasmic reticulum (ER) stress-mediated apoptotic and autophagic cell death is implicated in a wide range of diseases, including cerebral ischemia and neurodegenerative diseases. Thapsigargin was used to induce ...
Wang, Juan Ni, Wei-Hua Hu, Ke-Bang Zhai, Xiao-Yu Xie, Fei Jie, Jing Zhang, Nan-Nan Jiang, Li-Na Yuan, Hong-Yan Tai, Gui-Xiang
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Published in
Cancer science
Mucin 1 (MUC1), as an oncogene, is overexpressed in hepatocellular carcinoma (HCC) cells and promotes the progression and tumorigenesis of HCC through JNK/TGF-β signaling pathway. In the present study, RNA interference (RNAi) and JNK inhibitor SP600125, which target MUC1 and/or JNK, were used to treat HCC cells in vitro, and the results showed that...
De Luca, Anastasia Carpanese, Debora Rapanotti, Maria Cristina Viguria, Tara Mayte Suarez Forgione, Maria Antonietta Rotili, Dante Fulci, Chiara Iorio, Egidio Quintieri, Luigi Chimenti, Sergio
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Published in
Oncotarget
The novel nitrobenzoxadiazole (NBD) derivative MC3181 is endowed with remarkable therapeutic activity in mice bearing both sensitive and vemurafenib-resistant human melanoma xenografts. Here, we report that subtoxic concentrations of this compound significantly reduced invasiveness of BRAF-V600D mutated WM115 and WM266.4 melanoma cell lines derived...
Bates, Darcy Eastman, Alan
Published in
British journal of clinical pharmacology
Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have been classified as cytotoxic chemotherapy drugs that act during cellular mitosis, enabling them to target fast growing cancer cells. With the evolution of cancer drug development there has been a shift towards new "targeted" therapies to avoid the side effects ...
Liu, Xuqiang Chin, Jie-Fen Qu, Xinhua Bi, Haidi Liu, Yuan Yu, Ziqiang Zhai, Zanjing Qin, An Zhang, Bin Dai, Min
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Published in
Frontiers in pharmacology
Being a highly prevalent disease, osteoporosis causes metabolism defects. Low bone density, compromised bone strength, and an increased danger of fragility fracture are its main characteristics. Natural compounds have been considered as potential alternative therapeutic agents for treating osteoporosis. In this study, we demonstrated that a natural...
