Hoepner, Robert Bagnoud, Maud Pistor, Maximilian Salmen, Anke Briner, Myriam Synn, Helen Schrewe, Lisa Guse, Kirsten Ahmadi, Farhad Demir, Seray
...
Published in
Acta neuropathologica
The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression levels were quantified by ELISA and induction of T...
Ruan, Jia-Ping Chen, Ling Ma, Zheng-Liang
Published in
Journal of cellular biochemistry
This study investigated the activation of mitogen-activated protein kinases in the spinal dorsal horn to explore the mechanisms underlying morphine-induced acute and chronic hyperalgesia in mice. Male adult mice were given a single subcutaneous injection (SC) of morphine (1 μg/kg) or twice-daily administration of morphine (10 mg/kg/day) for 8 days....
Manu, T Mohan Anand, T Pandareesh, M D Kumar, P Bhuvanesh Khanum, Farhath
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Arjunic acid (AA) is one of the major active component of Terminalia arjuna known for its health benefits. In the present study, we evaluated cardioprotective potential of Terminalia arjuna extract (TAE) and AA against cobalt chloride (CoCl2)-induced hypoxia damage and apoptosis in rat cardiomyocytes. TAE (50 μg/ml) and AA (8 μg/ml) significantly (...
Zhao, Hong-Bo Jiang, You-Ming Hou, Ya-Jing Yan, Zhi-Yi Liu, Yue-Yun Li, Xiao-Juan Gong, Wei-Jun
Published in
Complementary Medicine Research
Background: Xiaoyaosan (XYS) has achieved definite curative effects in clinic. However, the mechanism is not clear. Previous studies of our team indicated XYS improved anxiety-like behaviors through inhibiting c-Jun N-terminal kinase (JNK) signaling pathway of hippocampus. Objectives: In the study, we explored whether the JNK signaling pathway is i...
Yang, Xi Xing, Hanying Liu, Jingzhen Yang, Linquan Ma, Huan Ma, Huijuan
Published in
Molecular medicine reports
The expression of microRNA‑802 (miR‑802) is known to be associated with insulin resistance (IR); however, the mechanism remains unclear. The present study investigated how miR‑802 contributes to the development of IR using C57BL/6J mice fed a high‑fat diet (HFD) to establish a model of IR. Adeno‑associated virus overexpressing miR‑802 was administe...
Wu, Shujin Sa, Rina Gu, Zhirong Zhao, Pei Yu, Jing Wang, Yanhong Ge, Bin
Published in
Pharmacology
Aim: The present study was performed to investigate the effect of Aesculus hippocastanum (AH; Venoplant®) on concanavalin A (ConA)-induced acute liver injury and explore the mechanism in mice. Methods: ConA (20 mg/kg) was administered via tail vein injection to induce hepatic damage. The groups of AH (Venoplant®) were given at 65.8, 131.6, and 263....
Akakpo, Jephte Y Ramachandran, Anup Duan, Luqi Schaich, Matthew A Jaeschke, Matthew W Freudenthal, Bret D Ding, Wen-Xing Rumack, Barry H Jaeschke, Hartmut
Published in
Toxicological sciences : an official journal of the Society of Toxicology
Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the United States and many western countries. However, the only clinically approved antidote, N-acetylcysteine, has a limited therapeutic window. 4-Methylpyrazole (4MP) is an antidote for methanol and ethylene glycol poisoning, and we have recently s...
Tang, Min Zhu, Wei-Ji Yang, Zu-Cheng He, Cheng-Song
Published in
Experimental and Therapeutic Medicine
Rheumatoid arthritis (RA) is a diffuse connective tissue disease. Brucine selectively inhibits cell immunity, immune hypersensitivity and induces apoptosis. The current study aimed to investigate effects of brucine on human fibroblast-like synoviocytes (HFLS) of RA and to clarify associated molecular mechanisms. HFLS-RA were treated with tumor necr...
Qin, Ruijie Zhang, Lina Lin, Dong Xiao, Fei Guo, Lixin
Published in
International Journal of Molecular Medicine
Although sirtuin 1 (Sirt1) has been found to be involved in diabetic vasculopathy and high glucose (HG)-mediated endothelial injury, the underlying mechanisms remain to be fully elucidated. The aim of the present study was to investigate the role of Sirt1 in HG-induced endothelial injury and its potential mechanism. In the present study, it was dem...
plotnikov, mark b. chernysheva, galina a. aliev, oleg i. smol’iakova, vera i. fomina, tatiana i. osipenko, anton n. rydchenko, victoria s. anfinogenova, yana j. khlebnikov, andrei i. schepetkin, igor a.
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c-Jun N-terminal kinase (JNK) is activated by various brain insults and is implicated in neuronal injury triggered by reperfusion-induced oxidative stress. Some JNK inhibitors demonstrated neuroprotective potential in various models, including cerebral ischemia/reperfusion injury. The objective of the present work was to study the neuroprotective a...
