Sánchez-Duffhues, Gonzalo García de Vinuesa, Amaya van de Pol, Vera Geerts, Marlieke E de Vries, Margreet R Janson, Stef Gt van Dam, Hans Lindeman, Jan H Goumans, Marie-José Ten Dijke, Peter
...
Published in
The Journal of pathology
Endothelial-to-mesenchymal transition (EndMT) has been unveiled as a common cause for a multitude of human pathologies, including cancer and cardiovascular disease. Vascular calcification is a risk factor for ischemic vascular disorders and slowing calcification may reduce mortality in affected patients. The absence of early biomarkers hampers the ...
Pahng, Amanda R Paulsen, Rod I McGinn, M Adrienne Farooq, Muhammad A Edwards, Kimberly N Edwards, Scott
Published in
Alcohol (Fayetteville, N.Y.)
Alcohol use disorder (AUD) is a chronic, relapsing psychiatric disease characterized by the emergence of negative emotional states and the development of motivational deficits that manifest during alcohol withdrawal. Accordingly, alcohol may be sought after and taken in excessive amounts to alleviate withdrawal-related symptoms. To develop more eff...
Ni, Hua-Dong Xu, Long Sheng Wang, Yungong Li, Hongbo An, Kang Liu, Mingjuan Liu, Qianying Deng, Houshen He, Qiuli Huang, Bing
...
Published in
Molecular pain
Descending nociceptive modulation from the supraspinal structures has an important role in cancer-induced bone pain (CIBP). Midbrain ventrolateral periaqueductal gray (vlPAG) is a critical component of descending nociceptive circuits; nevertheless, its precise cellular and molecular mechanisms involved in descending facilitation remain elusive. Our...
Colli, Maikel L. Paula, Flavia M. Marselli, Lorella Marchetti, Piero Roivainen, Merja Eizirik, Decio L. Op de beeck, Anne
Published in
Journal of Innate Immunity
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive pancreatic β cell destruction. The disease is triggered by a combination of genetic and environmental factors, but the mechanisms leading to the triggering of early innate and late adaptive immunity and consequent progressive pancreatic β cell death r...
Yang, Jin Won Murray, Ben Barbier-Torres, Lucia Liu, Ting Liu, Zhenqiu Yang, Heping Fan, Wei Wang, Jiaohong Li, Yuan Seki, Ekihiro
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Prohibitin 1 (PHB1) is a mitochondrial chaperone whose expression is dysregulated in cancer. In liver cancer, PHB1 acts as a tumor suppressor, but the mechanisms of tumor suppression are incompletely understood. Here we aimed to determine PHB1 target genes to better understand how PHB1 influences liver tumorigenesis. Using RNA-Seq analysis, we foun...
Xia, Yue-Feng Chang, Jing Yang, Jin-Feng Ouyang, Wen Pitt, Bruce Billiar, Timothy Zhang, Li-Ming
Published in
International Journal of Molecular Medicine
Mechanical ventilation may cause ventilator-induced lung injury (VILI). Canonical Wnt signaling has been reported to serve an important role in the pathogenesis of VILI. Bioinformatics analysis revealed that canonical and non-canonical Wnt signaling pathways were activated in VILI. However, the role of non-canonical Wnt signaling in the pathogenesi...
Paik, Seungwha Choi, Seunga Lee, Kang-In Back, Yong Woo Son, Yeo-Jin Jo, Eun-Kyeong Kim, Hwa-Jung
Published in
Microbes and infection
Mycobacterial acyl carrier protein (AcpM; Rv2244) is a meromycolate extension acyl carrier protein of Mycobacterium tuberculosis (Mtb), which participates in multistep mycolic acid biosynthesis. However, the function of AcpM in host-mycobacterium interactions during infection remains largely uncharacterized. Here we show that AcpM inhibits host cel...
Chen, Mingliang Wang, Chenying Li, Zengpeng Chen, Jianming
Published in
Fish & shellfish immunology
Complement C3 is a pivotal component of three cascades of complement activation. C3 in circulation is mainly provided by the hepatic cecum. The expression and secretion of C3 by hepatocytes is increased during acute inflammation. The detailed information on the regulationary mechanism underlying C3 transcriptional activation is limited. Here, we ch...
Schepetkin, Igor A. Khlebnikov, Andrei I. Potapov, Andrei S. Kovrizhina, Anastasia R. Matveevskaya, Vladislava V. Belyanin, Maxim L. Atochin, Dmitry N. Zanoza, Svitlana O. Gaidarzhy, Nadiya M. Lyakhov, Sergiy A.
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Published in
European journal of medicinal chemistry
Jiang, Conglin Zou, Xiang Zhu, Renqing Shi, Yimin Wu, Zehan Zhao, Fan Chen, Liang
Published in
Journal of neurosurgery
Intraventricular hemorrhage (IVH) is found in approximately 40% of intracerebral hemorrhages and is associated with increased mortality and poor functional outcome. Cognitive impairment is one of the complications and occurs due to various pathological changes. Amyloid beta (Aβ) accumulation and neuroinflammation, and the Alzheimer disease-like pat...
