Chang, Jia-Feng Hsieh, Chih-Yu Liou, Jian-Chiun Liu, Shih-Hao Hung, Chi-Feng Lu, Kuo-Cheng Lin, Chih-Cheng Wu, Chang-Chin Ka, Shuk-Man Wen, Li-Li
...
Published in
Toxins
Osteogenesis in human arterial smooth muscle cell (HASMC) is a key feature of uremic vascular calcification (UVC). Concerning pro-oxidant properties of p -cresyl sulfate (PCS), the therapeutic effect of reactive oxygen species (ROS) scavenger on PCS triggered inflammatory signaling transduction in osteogenesis was investigated in this translational...
Zhu, Shangling Ye, Yuanmei Shi, Yiming Dang, Junlong Feng, Xiaoxue Chen, Yingdi Liu, Fang Olsen, Nancy Huang, Jianlin Zheng, Song Guo
...
Published in
Frontiers in Immunology
Activated fibroblast-like synoviocytes (FLSs) play a central role in the formation of synovial pannus and joint destruction in rheumatoid arthritis (RA). Targeting FLSs could be a potential therapeutic strategy. The objective of this study is to explore the role of c-Jun N-terminal kinase (JNK) in proliferation, migration and invasion of FLSs promo...
Li, Xiaolin Shi, Weihong Xiong, Qinghua Hu, Yungang Qin, Xu Wan, Guanqun Zeng, Qi
Published in
The Journal of international medical research
This study investigated the effects of leptin on intestinal flora and inflammation in mice with high-fat diet (HFD)-induced obesity. Mice were fed an HFD for 8 weeks; some were concurrently administered oral leptin for 4 weeks. Pathological changes in adipose tissue were detected using hematoxylin-eosin staining; endotoxin content in adipose tissue...
Sang, Yizhen Tsuji, Kenji Inoue-Torii, Akiko Fukushima, Kazuhiko Kitamura, Shinji Wada, Jun
Published in
International Journal of Molecular Sciences
Podocyte injury is an independent risk factor for the progression of renal diseases. Semaphorin3A (SEMA3A), expressed in podocytes and tubular cells in the mammalian adult kidneys, has been reported to regulate diverse biological functions and be associated with renal diseases. Here, we investigated pathological roles of SEMA3A signaling on podocyt...
Sang, Yizhen Tsuji, Kenji Inoue-Torii, Akiko Fukushima, Kazuhiko Kitamura, Shinji Wada, Jun
Podocyte injury is an independent risk factor for the progression of renal diseases. Semaphorin3A (SEMA3A), expressed in podocytes and tubular cells in the mammalian adult kidneys, has been reported to regulate diverse biological functions and be associated with renal diseases. Here, we investigated pathological roles of SEMA3A signaling on podocyt...
Cho, Jung-Hyun Lee, Seulah Jeon, Hyeyoung Kim, Ah Hyun Lee, Wonjong Lee, Yujeong Yang, Seonguk Yun, Jeanho Jung, Young-Suk Lee, Jaewon
...
Published in
Neurotoxicity research
Tetrabromobisphenol A (TBBPA) is widely used in materials like plastics and textiles as a fire retardant. In a previous study, we reported TBBPA might disrupt hippocampal neurogenesis and neurocognitive function in mice. However, the mechanism responsible for these effects has not been established. The present study was undertaken to investigate th...
Chang, Yuhan Hsiao, Yi-min Hu, Chih-Chien Chang, Chih-Hsiang Li, Cai-Yan Ueng, Steve W. N. Chen, Mei-Feng
Published in
International Journal of Molecular Sciences
Because of lipopolysaccharide (LPS)-mediated effects on osteoclast differentiation and bone loss, periprosthetic joint infection (PJI) caused by Gram-negative bacteria increases the risk of aseptic loosening after reimplantation. Synovial fluid interleukin-16 (IL-16) expression was higher in patients with PJI than in patients without joint infectio...
Yung, Justin Hou Ming Giacca, Adria
Published in
Cells
Obesity has been described as a global epidemic and is a low-grade chronic inflammatory disease that arises as a consequence of energy imbalance. Obesity increases the risk of type 2 diabetes (T2D), by mechanisms that are not entirely clarified. Elevated circulating pro-inflammatory cytokines and free fatty acids (FFA) during obesity cause insulin ...
Su, Li Meng, Jian-Yu Yang, Hong Zhang, Chang-Yu
Published in
Frontiers in Physiology
Ostrinia furnacalis , an important pest of corn, has substantial detrimental effects on corn production. The mitogen-activated protein kinase (MAPK) signaling pathway plays a pivotal role in an insect’s resistance to environmental stress. The expression levels of JNK and p38 have been well recorded in several insects under different environmental s...
Miladiyah, Isnatin Yuanita, Emmy Nuryadi, Satyo Jumina, Jumina Haryana, Sofia Mubarika Mustofa, Mustofa
Published in
Current Therapeutic Research, Clinical and Experimental
Background The increasing rate of cancer chemoresistance and adverse side effects of therapy have led to the wide use of various chemotherapeutic combinations in cancer management, including lymphoid malignancy. Objective We investigated the effects of a combination of 1,3,6-trihydroxy-4,5,7-trichloroxanthone (TTX) and doxorubicin on the Raji lymph...
