Hu, Lanlin Liang, Yutong Wu, Kelv Wang, Caixia Zhang, Tao Peng, Rui Zou, Fangdong
Published in
Annals of Translational Medicine
Background Colorectal cancer (CRC) is the third major cause of cancer-related death worldwide, and fluorouracil (5-FU) is widely used in the treatment of CRC. However, acquired resistance to 5-FU has become an obstacle in the effective treatment of CRC. Adenosine triphosphate (ATP)-binding cassette sub-family G member 2 (ABCG2) has been found highl...
Chen, Tingting Cai, Chengyun Wang, Lifeng Li, Shixin Chen, Ling
Published in
Frontiers in Pharmacology
Inhibition of Ras farnesylation in acute has been found to upregulate the α7 nicotinic acetylcholine receptor (α7nAChR) activity. This study was carried out to investigate the effect of chronic administration for 7 days of farnesyl transferase inhibitor lonafarnib (50 mg/kg, intraperitoneally injected) to male mice on the expression and activity of...
Lai, Benjamin Wu, Chien-Hsiang Lai, Jenn-Haung
Published in
Cells
The c-Jun-N-terminal kinase (JNK) is a critical mediator involved in various physiological processes, such as immune responses, and the pathogenesis of various diseases, including autoimmune disorders. JNK is one of the crucial downstream signaling molecules of various immune triggers, mainly proinflammatory cytokines, in autoimmune arthritic condi...
Tong, Xin Li, Mengyun Liu, Na Huang, Wanjie Xue, Xindong Fu, Jianhua
Published in
Molecular Medicine Reports
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in premature infants, and alveolar dysplasia and pulmonary vascular development disorders are the predominant pathological features. Apoptosis of lung epithelial cells is a key factor in the pathological process of alveolar developmental arrest. Endoplasmic reticulum stress (E...
Anfinogenova, Nina D. Quinn, Mark T. Schepetkin, Igor A. Atochin, Dmitriy N.
Published in
Cells
Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases. Alarmins, also known as damage-associated molecular patterns, are released in the presence of neuroinflammation and in the acute phase of ischemia. Defensins, cathelicidin, high-mobility group box prote...
Li, Y S Zhang, X R Yu, M J Hu, X H Yang, J C Huang, Y Luo, G X He, W F
Published in
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
目的： 探讨白细胞介素17A(IL-17A)调控小鼠角质形成细胞(KC)表达IL-1β和IL-23的机制。 方法： 从400只新生雌雄不限C57BL/6野生型小鼠皮肤中分离原代KC，用含体积分数10%胎牛血清的RPMI 1640培养基培养于24孔板中，用于以下实验。(1)取细胞，采用随机数字表法(分组方法下同)分为磷酸盐缓冲液(PBS)对照组、IL-17A刺激组，分别加入10 μL的PBS、质量浓度为100 ng/mL的IL-17A培养6 h，采用实时荧光定量反转录PCR法检测细胞中IL-1β和IL-23 mRNA表达水平，每组3个样本。(2)取细胞，分为二甲基亚砜(DMSO)对照组、IL-17A＋DMSO组、IL-17A＋核因子κB抑制剂组、IL-17A＋信号转导及转录激活因子3(STAT...
Yi, La Cui, Jie Wang, Wenqian Tang, Weifeng Teng, Fangzhou Zhu, Xueyi Qin, Jingjing Wuniqiemu, Tulake Sun, Jing Wei, Ying
...
Published in
Frontiers in Pharmacology
Allergic asthma has been considered as a respiratory disorder with pathological features of airway inflammation and remodeling, which involves oxidative stress. Formononetin (FMT) is a bioactive isoflavone obtained from Chinese herb Radix Astragali, and has been reported to have notable anti-inflammatory and antioxidant effects in several diseases....
Saleem, Muhammad Zubair Alshwmi, Mohammed Zhang, He Din, Syed Riaz Ud Nisar, Muhammad Azhar Khan, Muhammad Alam, Shahid Alam, Gulzar Jin, Lingling Ma, Tonghui
...
Published in
Frontiers in Pharmacology
Breast cancer is the most heterogenous cancer type among women across the world. Despite concerted efforts, breast cancer management is still unsatisfactory. Interplay between apoptosis and autophagy is an imperative factor in categorizing therapeutics for cancer treatment. Proscillaridin A (PSD-A), a well-known cardiac glycoside used for cardiac a...
Kim, So Young Hwangbo, Hyun Lee, Hyesook Park, Cheol Kim, Gi-Young Moon, Sung-Kwon Yun, Seok Joong Kim, Wun-Jae Cheong, Jaehun Choi, Yung Hyun
...
Published in
International Journal of Molecular Sciences
Hepatocellular carcinoma (HCC) has a high mortality rate worldwide, and treatment is very limited due to its high recurrence and low diagnosis rate, and therefore there is an increasing need to develop more effective drugs to treat HCC. Coptisine is one of the isoquinoline alkaloids, and it has various pharmacological effects. However, the evidence...
Kirpotina, Liliya N. Schepetkin, Igor A. Hammaker, Deepa Kuhs, Amanda Khlebnikov, Andrei I. Quinn, Mark T.
Published in
Frontiers in Pharmacology
Rheumatoid arthritis (RA) is a chronic autoimmune disease involving joint and bone damage that is mediated in part by proteases and cytokines produced by synovial macrophages and fibroblast-like synoviocytes (FLS). Although current biological therapeutic strategies for RA have been effective in many cases, new classes of therapeutics are needed. We...
