Dresler, Josephine Avella, Ignazio Damm, Maik Dersch, Ludwig Krämer, Jonas Vilcinskas, Andreas Lüddecke, Tim
Published in
Frontiers in Arachnid Science
Spiders are ancient and highly successful predators, which use venom for both predation and defense. Their venoms are complex mixtures of potent biological molecules, emerging as a prolific source of biomolecular innovation in agriculture, biomedicine, and bioeconomy. While small cysteine-rich neurotoxins are typically considered the main component...
Sosa, Yvett Kapur, Bhav Hurtak, Jessica Kingsley, Laura J. Wu, Hao Gruber, Stefanie Nar, Herbert Khattabi, Saad Moral, Jesus Seco Lucas, Maria Fátima
...
Published in
Frontiers in Chemical Biology
Introduction: Biocatalysis, particularly through engineered enzymes, presents a cost-effective, efficient, and eco-friendly approach to compound synthesis. We sought to identify ketoreductases capable of synthesizing optically pure alcohols or ketones, essential chiral building blocks for active pharmaceutical ingredients. Methods: Using BioMatchMa...
Zeng, Fei Pan, Yongchun Lu, Qianglan Luan, Xiaowei Qin, Shurong Liu, Yuta Liu, Zhiyong Yang, Jingjing He, Bangshun Song, Yujun
...
Published in
Advanced healthcare materials
Employing tumor whole cells for tumor immunotherapy is a promising tumor therapy proposed in the early stage, but its therapeutic efficacy is weakened by the methods of eliminating pathogenicity and the mass ratio of the effective antigen carried by itself. Here, by adding gold ion to live cancer cells in the microfluidic droplets, this work obtain...
Lazic, Jelena Filipovic, Vuk Pantelic, Lena Milovanovic, Jelena Vojnovic, Sandra Nikodinovic-Runic, Jasmina
Published in
Frontiers in Bioengineering and Biotechnology
Bacterial natural products (BNPs) are very important sources of leads for drug development and chemical novelty. The possibility to perform late-stage diversification of BNPs using biocatalysis is an attractive alternative route other than total chemical synthesis or metal complexation reactions. Although biocatalysis is gaining popularity as a gre...
Garg, Ashna Rendina, Dominick Bendale, Hersh Akiyama, Takahiko Ojima, Iwao
Published in
Frontiers in Chemistry
Asymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone for the efficient creation of enantiopure chiral molecules characterized by their high selectivity. In this review, we delve into the realm of asymmetric catalytic reactions, which spans various methodologies, each contributing to the broader landscape of the...
Kluczka, Eugénie Rinaldo, Valentin Coutable-Pennarun, Angélique Stines-Chaumeil, Claire Martin, Nicolas
Biomolecular condensates are membraneless organelles that orchestrate various metabolic pathways in living cells. Understanding how these crowded structures regulate enzyme reactions remains yet challenging due to their dynamic and intricate nature. Coacervate microdroplets formed by associative liquid‐liquid phase separation of oppositely charged ...
Spalletta, Alexis Joly, Nicolas Martin, Patrick
Carbohydrate-based surfactants are amphiphilic compounds containing hydrophilic moietieslinked to hydrophobic aglycones. More specifically, carbohydrate esters are biosourced andbiocompatible surfactants derived from inexpensive renewable raw materials (sugars and fatty acids).Their unique properties allow them to be used in various areas, such as ...
Fu, Caicai Hou, Lirui Chen, Dingchun Huang, Teng Yin, Shutao Ding, Ping Liao, Qiansui Huang, Xiaolin Xiong, Yonghua Ge, Jun
...
Published in
Journal of agricultural and food chemistry
Mycotoxin contamination is an important issue for food safety and the environment. Removing mycotoxins from food without losing nutrients and flavor components remains a challenge. In this study, a novel strategy was proposed for the targeted removal of aflatoxin B1 (AFB1) from peanut oil using an amphipathic enzyme-metal hybrid nanoreactor (PL-GOx...
Gu, Shanna Zhu, Fuzhou Zhang, Lin Wen, Jianping
Published in
Journal of agricultural and food chemistry
Mid-to-long-chain dicarboxylic acids (DCAi, i ≥ 6) are organic compounds in which two carboxylic acid functional groups are present at the terminal position of the carbon chain. These acids find important applications as structural components and intermediates across various industrial sectors, including organic compound synthesis, food production,...
Wolf, Megan E. Lalande, Anne T. Newman, Brianne L. Bleem, Alissa C. Palumbo, Chad T. Beckham, Gregg T. Eltis, Lindsay D.
Published in
Applied and Environmental Microbiology
Lignin, an abundant aromatic polymer found in plant biomass, is a promising renewable replacement for fossil fuels as a feedstock for the chemical industry. Strategies for upgrading lignin include processes that couple the catalytic fractionation of biomass and biocatalytic transformation of the resulting aromatic compounds with a microbial cell fa...
