Zhou, Mingzhu Ge, Xiaoqian Ke, Da-Ming Tang, Huan Zhang, Jun-Zheng Calvaresi, Matteo Gao, Bin Sun, Lining Su, Qianqian Wang, Haifang
...
Published in
Frontiers in Chemistry
Lanthanide-doped upconversion nanoparticles can convert long wavelength excitation radiation to short wavelength emission. They have great potential in biomedical applications, such as bioimaging, biodetection, drug delivery, and theranostics. However, there is little information available on their bioavailability and biological effects after oral ...
Chen, C.-Y. Oliver Milbury, Paul E. Blumberg, Jeffrey B.
Published in
Antioxidants
Almond skins are a waste byproduct of blanched almond production. Polyphenols extracted from almond skins possess antioxidant activities in vitro and in vivo. Thus, we examined the pharmacokinetic profile of almond skin polyphenols (ASP) and their effect on measures of oxidative stress. In a randomized crossover trial, seven adults consumed two acu...
Menssen, Hans D Quinlan, Michelle Kemp, Charisse Tian, Xianbin
Published in
Clinical pharmacology in drug development
Asciminib (ABL001) is an orally administered allosteric inhibitor of the BCR-ABL tyrosine kinase. The current study evaluated the relative bioavailability of its 2 tablet variants, AAA and NXA, compared with the capsule CSF and assessed the impact of food in healthy participants in a 2-arm, randomized, open-label, 4-way crossover design. The primar...
Yang, Gang Wu, Feihua Chen, Minyan Jin, Jian Wang, Rong Yuan, Yongfang
Published in
International journal of nanomedicine
Gypenosides (GPS) have been used as traditional medicine for centuries with various pharmacological effects. However, its therapeutic effects were restricted owing to the poor lipid and water solubility and low absorption. This study aimed to develop nanostructured lipid carriers (NLCs) containing a bile salt formulation (sodium glycocholate, SGC) ...
Reboul, Emmanuelle
Published in
IUBMB life
Vitamin E is an essential molecule for our development and health. It has long been thought that it was absorbed and transported through cellular membranes by a passive diffusion process. However, data obtained during the past 15 years showed that its absorption is actually mediated, at least in part, by cholesterol membrane transporters including ...
Chauhan, Meenakshi K Bhatt, Nidhi
Published in
Journal of pharmaceutical sciences
Polymyxin-B (Poly-B) is an effective antibiotic used to treat infections mainly caused due to sensitive gram-negative bacteria. They belong to the group of cyclic peptide antibiotics and are minimally absorbed from the gastrointestinal tract. This arises the need for bioavailability enhancement and is achieved in the present case using niosomes as ...
Aguirre, Luis García Olmedo, Isabel Ruiz Nolasco, Araceli Medina Romo, Yamanqui Ibáñez Reyes, Liz Medina Hernández, Dolores Adriana Aguilera Vargas, Ana Laura Rojas
Published in
Clinical pharmacology in drug development
An orally disintegrating film formulation of sildenafil 50 mg (CL Pharm Co, Ltd) was used in this study and compared to the market-available product film coated tablets (Viagra® , Pfizer, Mexico). The objective was to compare the pharmacokinetic properties of these products after a single-dose administration to 47 healthy male volunteers (aged 19-4...
Pérez-Sánchez, Almudena Cuyàs, Elisabet Ruiz-Torres, Verónica Agulló-Chazarra, Luz Verdura, Sara González-Álvarez, Isabel Bermejo, Marival Joven, Jorge Micol, Vicente Bosch-Barrera, Joaquim
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Published in
International Journal of Molecular Sciences
An ever-growing number of preclinical studies have investigated the tumoricidal activity of the milk thistle flavonolignan silibinin. The clinical value of silibinin as a bona fide anti-cancer therapy, however, remains uncertain with respect to its bioavailability and blood–brain barrier (BBB) permeability. To shed some light on the absorption and ...
Pulse, Mark E. Weiss, William J. Kers, Johan A. DeFusco, Anthony W. Park, Jae H. Handfield, Martin
Published in
Antimicrobial Agents and Chemotherapy
Lantibiotics present an attractive scaffold for the development of novel antibiotics. We report here a novel lantibiotic for the treatment of Clostridium difficile infection. The lead compounds were selected from a library of over 700 single- and multiple-substitution variants of the lantibiotic mutacin 1140 (MU1140). The best performers in vitro a...
Garcia-Prats, Anthony J. Purchase, Susan E. Osman, Muhammad Draper, Heather R. Schaaf, H. Simon Wiesner, Lubbe Denti, Paolo Hesseling, Anneke C.
Published in
Antimicrobial Agents and Chemotherapy
This study characterized the pharmacokinetics of novel 100-mg levofloxacin dispersible tablets in 24 children aged
