Published in Proteins
G-protein coupled receptors (GPCRs), a major gatekeeper of extracellular signals on plasma membrane, are unarguably one of the most important therapeutic targets. Given the recent discoveries of allosteric modulations, an allosteric wiring diagram of intramolecular signal transductions would be of great use to glean the mechanism of receptor regula...
Published in Human brain mapping
Cerebral neuroplasticity after stroke has been elucidated by functional neuroimaging. However, little is known concerning how topological properties of the cortical motor-related network evolved following subcortical stroke. In the present study, we investigated 24 subcortical stroke patients with only left motor pathway damaged and 24 matched heal...
Published in Brain : a journal of neurology
Traumatic brain injury affects brain connectivity by producing traumatic axonal injury. This disrupts the function of large-scale networks that support cognition. The best way to describe this relationship is unclear, but one elegant approach is to view networks as graphs. Brain regions become nodes in the graph, and white matter tracts the connect...
Published in KSCE Journal of Civil Engineering
In this study, optimal water quality sensor placement is performed based on the sensitivity of flow direction under different water demands for detecting accidental water quality contamination. First, Betweenness Centrality (BC), a network analysis method, is used for determining optimal locations considering a network’s connectivity. Second, senso...
Published in Brain connectivity
Neuroimaging studies of functional connectivity using graph theory have furthered our understanding of the network structure in temporal lobe epilepsy (TLE). Brain network effects of anti-epileptic drugs could influence such studies, but have not been systematically studied. Resting-state functional MRI was analyzed in 25 patients with TLE using gr...
Published in Neural regeneration research
Temporal lobe resection is an important treatment option for epilepsy that involves removal of potentially essential brain regions. Selective amygdalohippocampectomy is a widely performed temporal lobe surgery. We suggest starting the incision for selective amygdalohippocampectomy at the inferior temporal gyrus based on diffusion magnetic resonance...
Betweenness centrality is one of the basic concepts in the analysis of social networks. Initial definition for the betweenness of a node in a graph is based on the fraction of the number of geodesics (shortest paths) between any two nodes that given node lies on, to the total number of the shortest paths connecting these nodes. This method has quad...
The betweenness centrality is one of the basic concepts in the analysis of the social networks. Initial definition for the betweenness of a node in the graph is based on the fraction of the number of geodesics (shortest paths) between any two nodes that given node lies on, to the total number of the shortest paths connecting these nodes. This metho...
The growth in size and complexity of supply chains has led to compounded risk exposure, which is hard to measure with existing risk management approaches. In this study, we apply the concept of systemic risk to show that centrality metrics can be used for complex supply network risk assessment. We review and select metrics, and set up an exemplary ...
Published in Cerebral cortex (New York, N.Y. : 1991)
Spontaneous brain activity is spatially and temporally organized in the absence of any stimulation or task in networks of cortical and subcortical regions that appear largely segregated when imaged at slow temporal resolution with functional magnetic resonance imaging (fMRI). When imaged at high temporal resolution with magneto-encephalography (MEG...
