Published in Frontiers in Molecular Biosciences
Myeloid differentiating factor 88 (Myd88) is a universal adaptor protein that plays a critical role in innate immunity by mediating TLR downstream signaling. Myd88 death domain (DD) forms an oligomeric complex by association with other DD-containing proteins such as IRAK4. Despite its universal role, polymorphisms in Myd88 can result in several dis...
Published in Biomolecules
Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, with two metal ion cofactors SOD1 is extremely robust, the de-metallated apo form is intrinsically dis...
Published in International journal of molecular sciences
Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastroph...
Published in International Journal of Molecular Sciences
Dynamics and functions of the peroxisome proliferator-activated receptor (PPAR)-α are modulated by the types of ligands that bind to the orthosteric sites. While several X-ray crystal structures of PPAR-α have been determined in their agonist-bound forms, detailed structural information in their apo and antagonist-bound states are still lacking. To...
Published in Conservation biology : the journal of the Society for Conservation Biology
廊道的建设旨在通过减少自然生境向人造环境转变过程中所导致的景观碎片化来提高物种的生存机会。保护科学家通常依赖于一种廊道模型 (一般是最低成本模型或电流模型) 来设计廊道连接, 而他们的选择很多时候并不是根据理论或经验证据。我们开发了一个方法来实证地确认目标物种是否会在当前的景观条件下使用这两个模型设计的廊道。我们将这一方法应用于加蓬 (Gabon) 西南部两个国家公园之间甘巴城 (Gamba) 的景观。我们记录了样带上非洲丛林象 (Loxodonta cyclotis) 、森林野水牛 (Syncerus caffer nanus), 以及西部低地大猩猩 (Gorilla gorilla gorilla) 和中部黑猩猩 (Pan troglodytes troglodytes) 这两种猩猩的活...
Variety of real-life structures can be simplified by a graph. Such simplification emphasizes the structure represented by vertices connected via edges. A common method for the analysis of the vertices importance in a network is betweenness centrality. The centrality is computed using the information about the shortest paths that exist in a graph. T...
It is currently understood that diseases are typically not caused by rogue errors in genetics but have both molecular and environmental causes from myriad overlapping interactions within an interactome. Genetic errors, such as that seen by a single-nucleotide polymorphism can lead to a dysfunctional cell, which in turn can lead to systemic disrupti...
Graph theory has been widely applied to the studies in biomedicine, and graph structural analytics, such as betweenness centrality, has played an important role in finding the most central vertices in graph data. Hence, betweenness centrality has been heavily applied to discover the most important genes with respect to multiple diseases in biomedic...
Published in Turkish Journal of Biology
Antibiotic resistance is one of the most important problems of our era and hence the discovery of new effective therapeutics is urgent. At this point, studying the allosteric communication pathways in the bacterial ribosome and revealing allosteric sites/residues is critical for designing new inhibitors or repurposing readily approved drugs for thi...
Published in International journal of neural systems
The mechanism of action of vagus nerve stimulation (VNS) is yet to be elucidated. To that end, the effects of VNS on the brain of epileptic patients were studied. Both when VNS was switched "On" and "Off", the brain activity of responders (R, seizure frequency reduction of over 50%) was compared to the brain activity of nonresponders (NR, seizure f...
