Published in Frontiers in neuroscience
The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen ...
Published in Journal of lipid research
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease tumor growth and metastasis. This hypothesis has neve...
Published in The Journal of pathology
Genomic amplification of the c-Jun proto-oncogene has been identified in ∼30% of dedifferentiated liposarcomas (DDLPS), but the functional contribution of c-Jun to the progression of DDLPS remains poorly understood. In previous work we showed that knock-down of c-Jun by RNA interference impaired the in vitro proliferation and in vivo growth of a DD...
Published in FEBS Letters
Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in blood plasma. Lysophosphatidate mediates many physiological and pathological processes by signaling through at least six G-protein coupled receptors to promote cell survival, proliferation and migr...
Published in Journal of lipid research
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and demonstrates medicinal relevance. LPA's functional roles are driven by extracellular signaling through at least six 7-transmembrane G protein-coupled receptors. These receptors are named LPA1-6 and sig...
Published in BBA - Molecular and Cell Biology of Lipids
•Glycerolipid-signaling pathways play an important role in human physiology and disease.•Glycerolipid-metabolizing enzymes are attractive targets for therapeutic intervention.•Chemical modulators interrupting glycerolipid signaling are essential tools in research.
Published in Microvascular Research
•We used an in vitro model of blood vessels, in which regression is driven by LPA.•Pericytes prevented regression (stabilized) endothelial cell tubes.•Pericytes stabilized tubes by promoting metabolism of LPA.•LPPs were the potential mediators of pericyte-induced stabilization.
Published in Clinica Chimica Acta
•Involvement of autotaxin (ATX) in HCC pathophysiology has been reported.•Serum ATX levels were not correlated with HCC burden or ATX mRNA expression in HCC.•Increased serum ATX levels were not reduced after HCC treatment.•Serum ATX levels in HCC patients were correlated with background liver fibrosis.•Background liver fibrosis but not tumor explai...
Published in The FEBS journal
Autotaxin (ATX) generates lysophosphatidic acid (LPA) from glycerophospholipid via lysophospholipase D (lysoPLD) activity in cooperation with phospholipase A. We studied its expression and possible functional roles in the ovary of nonfertile cycling rats. Immunohistochemistry revealed that ATX was located predominantly in luteal steroidogenic cells...
Published in Journal of lipid research
Lysophosphatidic acid (LPA) is a bioactive lipid mediator. Concentrations of the major LPA species in mouse plasma decreased uniformly following administration of a potent selective inhibitor of the LPA-generating lysophospholipase D autotaxin, identifying an active mechanism for removal of LPA from the circulation. LPA, akylglycerol phosphate (AGP...
