Tummala, Gayathri Crain, Adam Rowlan, Jessica Pepple, Kathryn L.
Published in
Investigative Ophthalmology & Visual Science
Purpose To characterize the intraocular immune cell infiltrate induced by intravitreal adeno-associated virus (AAV) gene therapy. Methods AAV vectors carrying plasmids expressing green fluorescent protein under the control of PR2.1 were injected intravitreally into AAV naive and AAV primed C57Bl/6 mice. Clinical inflammation was assessed using opti...
Donglang, Guan Tongtong, Liu Dan, Chen Chan, Zhu Changming, Wang Guang, Yu Yan, Yang Zongxiang, Tang
Published in
Frontiers in Medicine
The animal model is an important tool to study the mechanism of disease formation. Different animal models of pruritus have been adopted based on the purpose of researchers in the study of the itching mechanism. Although the symptoms of various models are quite different, scratching behavior is a key indicator. Therefore, it is necessary to find an...
Harms, Lauren Parras, Gloria G Michie, Patricia T Malmierca, Manuel S
Published in
Neuroscience
Mismatch negativity (MMN) is an electrophysiological signature that occurs in response to unexpected stimuli. It is often referred to as a measure of memory-based change detection, because the elicitation of a prediction error response relies on the formation of a prediction, which in turn, is dependent upon intact memory of previous auditory stimu...
Zhang, Ye Kuang, Wei Li, Danfeng Li, Yu Feng, Yi Lyu, Xinwei Huang, Gao-Bo Lian, Jian-Qi Yang, Xiao-Fei Hu, Cheng
...
Published in
Frontiers in Immunology
Natural killer-like B (NKB) cells, which are newly identified immune subsets, reveal a critical immunoregulatory property in the eradication of microbial infection via the secretion of interleukin (IL)-18. For the first time, this study investigated the role of NKB cells in secreting IL-18 in the pathogenesis of periodontitis. In this study, NKB ce...
Pineda-Lozano, Jessica Elizabeth Martínez-Moreno, Alma Gabriela Virgen-Carrillo, Carmen Alejandrina
Published in
Frontiers in Nutrition
Ischemic heart disease and stroke are two main causes of death that have prevailed for more than 15 years. Dyslipidemia and its parameters like hypercholesterolemia, hypertriglyceridemia, increase in low-density cholesterol, and a reduction of high-density cholesterol have been related with heart disease and risk of stroke. Approaches to improve th...
Bæk, Ole Cilieborg, Malene Skovsted Nguyen, Duc Ninh Bering, Stine Brandt Thymann, Thomas Sangild, Per Torp
Published in
Frontiers in Pediatrics
Background: After very preterm birth, male infants show higher mortality than females, with higher incidence of lung immaturity, neurological deficits, infections, and growth failure. In modern pig production, piglets dying in the perinatal period (up to 20%) often show signs of immature organs, but sex-specific effects are not clear. Using preterm...
Yu, Wentao Long, Huiqiang Gao, Jin Wang, Yidi Tu, Yu Sun, Liang Chen, Na
Published in
Dose-Response
Microdosimetry is a tool for the investigation of microscopic energy deposition of ionizing radiation. This work used Caenorhabditis elegans as a model to estimate the microdosimetric deposition level at the 60Co gamma radiation. Monte Carlo software PHITS was employed to establish irradiated nematodes model. The dose deposition of the entire body ...
ASAHINA, Makoto FUJINAWA, Reiko FUJIHIRA, Haruhiko MASAHARA-NEGISHI, Yuki ANDOU, Tomohiro TOZAWA, Ryuichi SUZUKI, Tadashi
Published in
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
N -Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1 −/− mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice have been problematic. In this study, B6- Ngly1 −/+ mice were crossed with Japanese wild mice-originated Ja...
Sun, Tao Wang, Ping Deng, Ting Tao, Xingbao Li, Bin Xu, Ying
Published in
Frontiers in Pharmacology
With the increase of the aging population, the high mortality and disability rates caused by ischemic stroke are some of the major problems facing the world, and they dramatically burden the society. Panax notoginseng (Burk) F. H. Chen, a traditional Chinese medicine, is commonly used for promoting blood circulation and removing blood stasis, and i...
Nasi, Sonia Castelblanco, Mariela Chobaz, Véronique Ehirchiou, Driss So, Alexander Bernabei, Ilaria Kusano, Teruo Nishino, Takeshi Okamoto, Ken Busso, Nathalie
...
Published in
Frontiers in Cell and Developmental Biology
Pathologic calcification of cartilage consists of the formation of basic calcium phosphate (BCP) and/or calcium pyrophosphate dihydrate (CPPD) containing calcium crystals in mature hyaline or articular cartilage and is associated with aging, cartilage injury and likely plays a role in accelerating the pathology of osteoarthritis (OA). The pathways ...
