Varotto, Bruna Luiza Roim Martinez, Raquel Chacon Ruiz Gouveia, Flavia Venetucci Antunes, Geiza Fernanda Fabri, Gisele Maria de Campos Ballester, Gerson Antequera, Reynaldo de Siqueira, Silvia Regina Dowgan Tesser... Fonoff, Erich Talamoni Teixeira, Manoel Jacobsen
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Published in
Frontiers in Neurology
Periodontal disease (PD) is an infectious-inflammatory oral disease that is highly prevalent among adolescence and adulthood and can lead to chronic orofacial pain and be associated with anxiety, stress and depression. This study aimed to identify anxiety-like behaviors in the ligature-induced murine preclinical model of PD in different phases of t...
Ehirchiou, Driss Bernabei, Ilaria Chobaz, Véronique Castelblanco, Mariela Hügle, Thomas So, Alexander Zhang, Li Busso, Nathalie Nasi, Sonia
Published in
Frontiers in Cell and Developmental Biology
Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification. However, this calcification process is poorly understood and treatments targeting the underlying disease mechanisms are lacking. The CD11b/CD18 integ...
Spendiff, Sally Howarth, Rachel McMacken, Grace Davey, Tracey Quinlan, Kaitlyn O'Connor, Emily Slater, Clarke Hettwer, Stefan Mäder, Armin Roos, Andreas
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Published in
Frontiers in Molecular Neuroscience
Introduction: Congenital myasthenic syndromes (CMS) are a diverse group of inherited neuromuscular disorders characterized by a failure of synaptic transmission at the neuromuscular junction (NMJ). CMS often present early with fatigable weakness and can be fatal through respiratory complications. The AGRN gene is one of over 30 genes known to harbo...
Kim, Young Sang Kim, Yu Jin Kim, Myung Joo Lee, Sang Jin Kwon, Hwang Lee, Jae Ho
Published in
Biomedicines
Current therapeutic medicines for endometriosis cannot be administered during assisted reproductive technology (ART) because they have bad effects during pregnancy. In this study, we created an animal model of endometriosis and evaluated the therapeutic effect of progestin (Dienogest), dopamine agonist (Cabergoline), and their combination (Dienoges...
Ye, Yang Zhu, Yu-Tian Tong, Hong-Xuan Han, Jing-Yan
Published in
Frontiers in Pharmacology
Background: Recanalization with tissue plasminogen activator (tPA) is the only approved agent available for acute ischemic stroke. But delayed treatment of tPA may lead to lethal intracerebral hemorrhagic transformation (HT). Numerous studies have reported that immunomodulators have good efficacy on tPA-induced HT in ischemic stroke models. The ben...
Tsai, Shin-Hwa Tsao, Chih-Yu Lee, Li-Jen
Published in
Frontiers in Neuroanatomy
Increased white matter neuron density has been associated with neuropsychiatric disorders including schizophrenia. However, the pathogenic features of these neurons are still largely unknown. Subplate neurons, the earliest generated neurons in the developing cortex have also been associated with schizophrenia and autism. The link between these neur...
Akiyama, Yoshiyuki Yao, Jian-Rong Kreder, Karl J O'Donnell, Michael A Lutgendorf, Susan K Lyu, Dan Maeda, Daichi Kume, Haruki Homma, Yukio Luo, Yi
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Published in
American journal of physiology. Renal physiology
Recent evidence revealed that Hunner type interstitial cystitis (HIC) is a robust inflammatory disease potentially associated with enhanced immune responses and histologically characterized by epithelial denudation and lymphoplasmacytic infiltration with frequent clonal expansion of infiltrating B cells. To date, few animal models that reproduce th...
Mahdy, Mohamed A. A. Younis, Waleed Ewaida, Zamzam
Published in
Frontiers in Veterinary Science
A novel coronavirus has been reported as the causative pathogen of the Coronavirus disease 2019 (COVID-19) outbreak in Wuhan city, China in December 2019. Due to the rapid spread of the virus worldwide, it has been announced as a pandemic by the World Health Organization (WHO). Hospitalized patients in Wuhan were associated with the Huanan seafood ...
Ariyoshi, Kentaro Hiroyama, Yota Fujiwara, Naoya Miura, Tomisato Kasai, Kosuke Nakata, Akifumi Fujishima, Yohei Ting Goh, Valerie Swee Yoshida, Mitsuaki A
Published in
Journal of Radiation Research
Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after rad...
García-González, Mario Muñoz, Fernando González-Cantalapiedra, Antonio López-Peña, Mónica Saulacic, Nikola
Published in
Animals : an Open Access Journal from MDPI
Simple Summary Vertical alveolar osteogenesis distraction (VAOD) technique appears to provide the best results in terms of vertical bone gain. Before its use in humans, most devices are tested on experimental animals. Currently, there is no consensus on which is the ideal biological animal model for VAOD studies. In this review, it has been found t...